Xenoreactivity of human clonal mesenchymal stem cells in a major histocompatibility complex-matched allogeneic graft-versus-host disease mouse model

Myung Shin Jeon, Hyun Ja Lim, Tac Ghee Yi, Moon Whan Im, Hyun Seung Yoo, Jung Hwa Choi, Eun Young Choi, Sun U. Song

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Abstract

Effects of mesenchymal stem cells (MSCs) on graft-versus-host disease (GVHD) have been actively investigated since the discovery of the immunomodulation property of MSCs about a decade ago. Human clonal MSCs (hcMSCs) were isolated from human bone marrow aspirate according to our newly established isolation protocol called subfractionation culturing method, and were evaluated for their efficacy on GVHD treatment, using a mouse MHC-matched B6 → BALB.B GVHD model system. Although the hcMSCs can suppress the allogeneic proliferation of human peripheral blood mononuclear cells in in vitro, the administration of the hcMSCs failed to reduce the GVHD-related mortality of the murine recipients. One of the reasons might be that murine cytokines such as IFN-γ and TNF-α cannot activate the hcMSCs. Based on these results, we suggest that xenogeneic MSCs may not be used for the treatment of GVHD.

Original languageEnglish
Pages (from-to)57-63
Number of pages7
JournalCellular Immunology
Volume261
Issue number1
DOIs
StatePublished - 1 Jan 2010

Fingerprint

Graft vs Host Disease
Major Histocompatibility Complex
Mesenchymal Stromal Cells
Immunomodulation
Blood Cells
Bone Marrow
Cytokines
Mortality
Therapeutics

Keywords

  • Clonal MSC
  • GVHD
  • IDO
  • IL-10
  • T cell

Cite this

Jeon, Myung Shin ; Lim, Hyun Ja ; Yi, Tac Ghee ; Im, Moon Whan ; Yoo, Hyun Seung ; Choi, Jung Hwa ; Choi, Eun Young ; Song, Sun U. / Xenoreactivity of human clonal mesenchymal stem cells in a major histocompatibility complex-matched allogeneic graft-versus-host disease mouse model. In: Cellular Immunology. 2010 ; Vol. 261, No. 1. pp. 57-63.
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Xenoreactivity of human clonal mesenchymal stem cells in a major histocompatibility complex-matched allogeneic graft-versus-host disease mouse model. / Jeon, Myung Shin; Lim, Hyun Ja; Yi, Tac Ghee; Im, Moon Whan; Yoo, Hyun Seung; Choi, Jung Hwa; Choi, Eun Young; Song, Sun U.

In: Cellular Immunology, Vol. 261, No. 1, 01.01.2010, p. 57-63.

Research output: Contribution to journalArticleResearchpeer-review

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