Wearable/disposable sweat-based glucose monitoring device with multistage transdermal drug delivery module

Hyunjae Lee, Changyeong Song, Yong Seok Hong, Min Sung Kim, Hye Rim Cho, Taegyu Kang, Kwangsoo Shin, Seung Hong Choi, Taeghwan Hyeon, Dae Hyeong Kim

Research output: Contribution to journalArticle

233 Citations (Scopus)

Abstract

Electrochemical analysis of sweat using soft bioelectronics on human skin provides a new route for noninvasive glucose monitoring without painful blood collection. However, sweat-based glucose sensing still faces many challenges, such as difficulty in sweat collection, activity variation of glucose oxidase due to lactic acid secretion and ambient temperature changes, and delamination of the enzyme when exposed to mechanical friction and skin deformation. Precise point-of-care therapy in response to the measured glucose levels is still very challenging. We present a wearable/disposable sweat-based glucose monitoring device integrated with a feedback transdermal drug delivery module. Careful multilayer patch design and miniaturization of sensors increase the efficiency of the sweat collection and sensing process. Multimodal glucose sensing, as well as its real-time correction based on pH, temperature, and humidity measurements, maximizes the accuracy of the sensing. The minimal layout design of the same sensors also enables a strip-type disposable device. Drugs for the feedback transdermal therapy are loaded on two different temperature-responsive phase change nanoparticles. These nanoparticles are embedded in hyaluronic acid hydrogel microneedles, which are additionally coated with phase change materials. This enables multistage, spatially patterned, and precisely controlled drug release in response to the patient’s glucose level. The system provides a novel closed-loop solution for the noninvasive sweat-based management of diabetes mellitus.

Original languageEnglish
Article numbere1601314
JournalScience Advances
Volume3
Issue number3
DOIs
StatePublished - Mar 2017

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Sweat
Glucose
Equipment and Supplies
Pharmaceutical Preparations
Nanoparticles
Temperature
Point-of-Care Systems
Miniaturization
Glucose Oxidase
Skin
Friction
Hydrogel
Hyaluronic Acid
Humidity
Lactic Acid
Diabetes Mellitus
Enzymes
Therapeutics

Cite this

Lee, H., Song, C., Hong, Y. S., Kim, M. S., Cho, H. R., Kang, T., ... Kim, D. H. (2017). Wearable/disposable sweat-based glucose monitoring device with multistage transdermal drug delivery module. Science Advances, 3(3), [e1601314]. https://doi.org/10.1126/sciadv.1601314
Lee, Hyunjae ; Song, Changyeong ; Hong, Yong Seok ; Kim, Min Sung ; Cho, Hye Rim ; Kang, Taegyu ; Shin, Kwangsoo ; Choi, Seung Hong ; Hyeon, Taeghwan ; Kim, Dae Hyeong. / Wearable/disposable sweat-based glucose monitoring device with multistage transdermal drug delivery module. In: Science Advances. 2017 ; Vol. 3, No. 3.
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abstract = "Electrochemical analysis of sweat using soft bioelectronics on human skin provides a new route for noninvasive glucose monitoring without painful blood collection. However, sweat-based glucose sensing still faces many challenges, such as difficulty in sweat collection, activity variation of glucose oxidase due to lactic acid secretion and ambient temperature changes, and delamination of the enzyme when exposed to mechanical friction and skin deformation. Precise point-of-care therapy in response to the measured glucose levels is still very challenging. We present a wearable/disposable sweat-based glucose monitoring device integrated with a feedback transdermal drug delivery module. Careful multilayer patch design and miniaturization of sensors increase the efficiency of the sweat collection and sensing process. Multimodal glucose sensing, as well as its real-time correction based on pH, temperature, and humidity measurements, maximizes the accuracy of the sensing. The minimal layout design of the same sensors also enables a strip-type disposable device. Drugs for the feedback transdermal therapy are loaded on two different temperature-responsive phase change nanoparticles. These nanoparticles are embedded in hyaluronic acid hydrogel microneedles, which are additionally coated with phase change materials. This enables multistage, spatially patterned, and precisely controlled drug release in response to the patient’s glucose level. The system provides a novel closed-loop solution for the noninvasive sweat-based management of diabetes mellitus.",
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Lee, H, Song, C, Hong, YS, Kim, MS, Cho, HR, Kang, T, Shin, K, Choi, SH, Hyeon, T & Kim, DH 2017, 'Wearable/disposable sweat-based glucose monitoring device with multistage transdermal drug delivery module', Science Advances, vol. 3, no. 3, e1601314. https://doi.org/10.1126/sciadv.1601314

Wearable/disposable sweat-based glucose monitoring device with multistage transdermal drug delivery module. / Lee, Hyunjae; Song, Changyeong; Hong, Yong Seok; Kim, Min Sung; Cho, Hye Rim; Kang, Taegyu; Shin, Kwangsoo; Choi, Seung Hong; Hyeon, Taeghwan; Kim, Dae Hyeong.

In: Science Advances, Vol. 3, No. 3, e1601314, 03.2017.

Research output: Contribution to journalArticle

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AU - Lee, Hyunjae

AU - Song, Changyeong

AU - Hong, Yong Seok

AU - Kim, Min Sung

AU - Cho, Hye Rim

AU - Kang, Taegyu

AU - Shin, Kwangsoo

AU - Choi, Seung Hong

AU - Hyeon, Taeghwan

AU - Kim, Dae Hyeong

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N2 - Electrochemical analysis of sweat using soft bioelectronics on human skin provides a new route for noninvasive glucose monitoring without painful blood collection. However, sweat-based glucose sensing still faces many challenges, such as difficulty in sweat collection, activity variation of glucose oxidase due to lactic acid secretion and ambient temperature changes, and delamination of the enzyme when exposed to mechanical friction and skin deformation. Precise point-of-care therapy in response to the measured glucose levels is still very challenging. We present a wearable/disposable sweat-based glucose monitoring device integrated with a feedback transdermal drug delivery module. Careful multilayer patch design and miniaturization of sensors increase the efficiency of the sweat collection and sensing process. Multimodal glucose sensing, as well as its real-time correction based on pH, temperature, and humidity measurements, maximizes the accuracy of the sensing. The minimal layout design of the same sensors also enables a strip-type disposable device. Drugs for the feedback transdermal therapy are loaded on two different temperature-responsive phase change nanoparticles. These nanoparticles are embedded in hyaluronic acid hydrogel microneedles, which are additionally coated with phase change materials. This enables multistage, spatially patterned, and precisely controlled drug release in response to the patient’s glucose level. The system provides a novel closed-loop solution for the noninvasive sweat-based management of diabetes mellitus.

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