Vitamin D deficiency and changes in serum vitamin D levels with treatment among tuberculosis patients in South Korea

Hyeon Kyoung Koo, Ji Sun Lee, Yun Jeong Jeong, Sun Mi Choi, Hyo Jae Kang, Hyo Jeong Lim, Ina Jeong, Jong Sun Park, Sang Min Lee, Seok Chul Yang, Chul Gyu Yoo, Young Whan Kim, Sung Koo Han, Jae Joon Yim

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Background and objective: Vitamin D deficiency has been reported to be associated with the development of active tuberculosis (TB), but many discrepancies exist among studies. The aims of this study were to compare the frequency of vitamin D deficiency in a Korean population of TB patients and control subjects, and to monitor the changes in vitamin D levels during TB treatment. Methods: Patients with newly diagnosed TB were prospectively enrolled. In addition, healthy volunteers or patients with diseases other than TB were enrolled as controls. Baseline serum 25-hydroxyvitamin D (25-OHD) levels were measured in both groups and compared. In the TB patients, measurements of serum 25-OHD were repeated 1 month after the initiation of treatment and again after completion of treatment. Results: In total, 116 patients with TB and 86 control subjects were recruited. The median 25-OHD concentration was not different in TB patients at diagnosis (13.9 ng/mL; interquartile range (IQR) 8.80-21.8) compared with control subjects (13.2 ng/mL; IQR 9.6-19.3) (P = 0.97). The frequency of vitamin D deficiency (≤10 ng/mL) was also not different in TB patients (36.2%) compared with controls (27.3%) (P = 0.21). In TB patients, the median 25-OHD concentration decreased significantly during treatment, to 12.5 ng/mL at 1 month and 11.0 ng/mL on completion of treatment (P = 0.01). Conclusions: Vitamin D levels do not appear to be associated with the development of TB in the Korean population. The median 25-OHD concentration decreased after treatment for TB. 25-OHD levels were compared in TB patients and control subjects, and changes in 25-OHD during TB treatment were monitored. In this Korean population, the prevalence of vitamin D deficiency did not differ between the two groups, but the median 25-OHD concentration decreased after TB treatment.

Original languageEnglish
Pages (from-to)808-813
Number of pages6
JournalRespirology
Volume17
Issue number5
DOIs
StatePublished - 1 Jul 2012

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Republic of Korea
Vitamin D Deficiency
Vitamin D
Tuberculosis
Serum
Therapeutics
Population

Keywords

  • change
  • treatment
  • tuberculosis
  • vitamin D deficiency

Cite this

Koo, Hyeon Kyoung ; Lee, Ji Sun ; Jeong, Yun Jeong ; Choi, Sun Mi ; Kang, Hyo Jae ; Lim, Hyo Jeong ; Jeong, Ina ; Park, Jong Sun ; Lee, Sang Min ; Yang, Seok Chul ; Yoo, Chul Gyu ; Kim, Young Whan ; Han, Sung Koo ; Yim, Jae Joon. / Vitamin D deficiency and changes in serum vitamin D levels with treatment among tuberculosis patients in South Korea. In: Respirology. 2012 ; Vol. 17, No. 5. pp. 808-813.
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title = "Vitamin D deficiency and changes in serum vitamin D levels with treatment among tuberculosis patients in South Korea",
abstract = "Background and objective: Vitamin D deficiency has been reported to be associated with the development of active tuberculosis (TB), but many discrepancies exist among studies. The aims of this study were to compare the frequency of vitamin D deficiency in a Korean population of TB patients and control subjects, and to monitor the changes in vitamin D levels during TB treatment. Methods: Patients with newly diagnosed TB were prospectively enrolled. In addition, healthy volunteers or patients with diseases other than TB were enrolled as controls. Baseline serum 25-hydroxyvitamin D (25-OHD) levels were measured in both groups and compared. In the TB patients, measurements of serum 25-OHD were repeated 1 month after the initiation of treatment and again after completion of treatment. Results: In total, 116 patients with TB and 86 control subjects were recruited. The median 25-OHD concentration was not different in TB patients at diagnosis (13.9 ng/mL; interquartile range (IQR) 8.80-21.8) compared with control subjects (13.2 ng/mL; IQR 9.6-19.3) (P = 0.97). The frequency of vitamin D deficiency (≤10 ng/mL) was also not different in TB patients (36.2{\%}) compared with controls (27.3{\%}) (P = 0.21). In TB patients, the median 25-OHD concentration decreased significantly during treatment, to 12.5 ng/mL at 1 month and 11.0 ng/mL on completion of treatment (P = 0.01). Conclusions: Vitamin D levels do not appear to be associated with the development of TB in the Korean population. The median 25-OHD concentration decreased after treatment for TB. 25-OHD levels were compared in TB patients and control subjects, and changes in 25-OHD during TB treatment were monitored. In this Korean population, the prevalence of vitamin D deficiency did not differ between the two groups, but the median 25-OHD concentration decreased after TB treatment.",
keywords = "change, treatment, tuberculosis, vitamin D deficiency",
author = "Koo, {Hyeon Kyoung} and Lee, {Ji Sun} and Jeong, {Yun Jeong} and Choi, {Sun Mi} and Kang, {Hyo Jae} and Lim, {Hyo Jeong} and Ina Jeong and Park, {Jong Sun} and Lee, {Sang Min} and Yang, {Seok Chul} and Yoo, {Chul Gyu} and Kim, {Young Whan} and Han, {Sung Koo} and Yim, {Jae Joon}",
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Vitamin D deficiency and changes in serum vitamin D levels with treatment among tuberculosis patients in South Korea. / Koo, Hyeon Kyoung; Lee, Ji Sun; Jeong, Yun Jeong; Choi, Sun Mi; Kang, Hyo Jae; Lim, Hyo Jeong; Jeong, Ina; Park, Jong Sun; Lee, Sang Min; Yang, Seok Chul; Yoo, Chul Gyu; Kim, Young Whan; Han, Sung Koo; Yim, Jae Joon.

In: Respirology, Vol. 17, No. 5, 01.07.2012, p. 808-813.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Vitamin D deficiency and changes in serum vitamin D levels with treatment among tuberculosis patients in South Korea

AU - Koo, Hyeon Kyoung

AU - Lee, Ji Sun

AU - Jeong, Yun Jeong

AU - Choi, Sun Mi

AU - Kang, Hyo Jae

AU - Lim, Hyo Jeong

AU - Jeong, Ina

AU - Park, Jong Sun

AU - Lee, Sang Min

AU - Yang, Seok Chul

AU - Yoo, Chul Gyu

AU - Kim, Young Whan

AU - Han, Sung Koo

AU - Yim, Jae Joon

PY - 2012/7/1

Y1 - 2012/7/1

N2 - Background and objective: Vitamin D deficiency has been reported to be associated with the development of active tuberculosis (TB), but many discrepancies exist among studies. The aims of this study were to compare the frequency of vitamin D deficiency in a Korean population of TB patients and control subjects, and to monitor the changes in vitamin D levels during TB treatment. Methods: Patients with newly diagnosed TB were prospectively enrolled. In addition, healthy volunteers or patients with diseases other than TB were enrolled as controls. Baseline serum 25-hydroxyvitamin D (25-OHD) levels were measured in both groups and compared. In the TB patients, measurements of serum 25-OHD were repeated 1 month after the initiation of treatment and again after completion of treatment. Results: In total, 116 patients with TB and 86 control subjects were recruited. The median 25-OHD concentration was not different in TB patients at diagnosis (13.9 ng/mL; interquartile range (IQR) 8.80-21.8) compared with control subjects (13.2 ng/mL; IQR 9.6-19.3) (P = 0.97). The frequency of vitamin D deficiency (≤10 ng/mL) was also not different in TB patients (36.2%) compared with controls (27.3%) (P = 0.21). In TB patients, the median 25-OHD concentration decreased significantly during treatment, to 12.5 ng/mL at 1 month and 11.0 ng/mL on completion of treatment (P = 0.01). Conclusions: Vitamin D levels do not appear to be associated with the development of TB in the Korean population. The median 25-OHD concentration decreased after treatment for TB. 25-OHD levels were compared in TB patients and control subjects, and changes in 25-OHD during TB treatment were monitored. In this Korean population, the prevalence of vitamin D deficiency did not differ between the two groups, but the median 25-OHD concentration decreased after TB treatment.

AB - Background and objective: Vitamin D deficiency has been reported to be associated with the development of active tuberculosis (TB), but many discrepancies exist among studies. The aims of this study were to compare the frequency of vitamin D deficiency in a Korean population of TB patients and control subjects, and to monitor the changes in vitamin D levels during TB treatment. Methods: Patients with newly diagnosed TB were prospectively enrolled. In addition, healthy volunteers or patients with diseases other than TB were enrolled as controls. Baseline serum 25-hydroxyvitamin D (25-OHD) levels were measured in both groups and compared. In the TB patients, measurements of serum 25-OHD were repeated 1 month after the initiation of treatment and again after completion of treatment. Results: In total, 116 patients with TB and 86 control subjects were recruited. The median 25-OHD concentration was not different in TB patients at diagnosis (13.9 ng/mL; interquartile range (IQR) 8.80-21.8) compared with control subjects (13.2 ng/mL; IQR 9.6-19.3) (P = 0.97). The frequency of vitamin D deficiency (≤10 ng/mL) was also not different in TB patients (36.2%) compared with controls (27.3%) (P = 0.21). In TB patients, the median 25-OHD concentration decreased significantly during treatment, to 12.5 ng/mL at 1 month and 11.0 ng/mL on completion of treatment (P = 0.01). Conclusions: Vitamin D levels do not appear to be associated with the development of TB in the Korean population. The median 25-OHD concentration decreased after treatment for TB. 25-OHD levels were compared in TB patients and control subjects, and changes in 25-OHD during TB treatment were monitored. In this Korean population, the prevalence of vitamin D deficiency did not differ between the two groups, but the median 25-OHD concentration decreased after TB treatment.

KW - change

KW - treatment

KW - tuberculosis

KW - vitamin D deficiency

UR - http://www.scopus.com/inward/record.url?scp=84862994205&partnerID=8YFLogxK

U2 - 10.1111/j.1440-1843.2012.02172.x

DO - 10.1111/j.1440-1843.2012.02172.x

M3 - Article

C2 - 22449254

AN - SCOPUS:84862994205

VL - 17

SP - 808

EP - 813

JO - Respirology

JF - Respirology

SN - 1323-7799

IS - 5

ER -