Visceral adiposity and skeletal muscle mass are independently and synergistically associated with left ventricular structure and function

The Korean Genome and Epidemiology Study

Juri Park, Nan Hee Kim, Seong Hwan Kim, Jin Seok Kim, Yong Hyun Kim, Hong Euy Lim, Eung Ju Kim, Jin Oh Na, Goo Yeong Cho, Inkyung Baik, Doo Man Kim, Dong Seop Choi, Seung Ku Lee, Chol Shin

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Abstract

Conclusions More visceral fat and less muscle mass are independently and synergistically associated with an increase in LV mass index and impairment of LV diastolic parameters. Further research is needed to explore the complex mechanisms underlying these associations.

Methods A total of 1941 participants without known cardiovascular disease were enrolled from the Korean Genome and Epidemiology Study. Visceral fat area (VFA) was assessed by computed tomography. Appendicular skeletal muscle mass (ASM) was estimated by dual-energy X-ray absorptiometry and was used as a percentage of body weight (ASM/Wt). LV structure and function were assessed by tissue Doppler imaging (TDI) echocardiography.

Results Across VFA tertiles, ASM increased, but ASM/Wt decreased (all P < 0.001). In multivariate models adjusted for conventional cardiovascular risk factors, LV mass index and LV diastolic parameters, such as left atrial dimension, TDI Ea velocity, and E/Ea ratio, were significantly impaired as VFA increased. On the other hand, an increase in ASM/Wt was associated with a decrease in LV mass index and improvement of LV diastolic parameters. With regard to LV mass index and TDI Ea velocity, VFA and ASM/Wt showed synergistic effects (all P interaction < 0.05). When both VFA and ASM/Wt were simultaneously included in the same model, both remained independent predictors of LV mass index and TDI Ea velocity.

Background Obesity and low muscle mass may coexist as age-related changes in body composition. We aimed to investigate the effect of visceral adiposity and skeletal muscle mass on left ventricular (LV) structure and function in the general population.

Original languageEnglish
Pages (from-to)951-955
Number of pages5
JournalInternational Journal of Cardiology
Volume176
Issue number3
DOIs
StatePublished - 20 Oct 2014

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Adiposity
Left Ventricular Function
Intra-Abdominal Fat
Epidemiology
Skeletal Muscle
Genome
Muscles
Doppler Echocardiography
Photon Absorptiometry
Body Composition
Cardiovascular Diseases
Obesity
Tomography
Body Weight
Research
Population

Keywords

  • Diastole
  • Echocardiography
  • Epidemiology
  • Left ventricular mass
  • Skeletal muscle mass
  • Visceral adiposity

Cite this

Park, Juri ; Kim, Nan Hee ; Kim, Seong Hwan ; Kim, Jin Seok ; Kim, Yong Hyun ; Lim, Hong Euy ; Kim, Eung Ju ; Na, Jin Oh ; Cho, Goo Yeong ; Baik, Inkyung ; Kim, Doo Man ; Choi, Dong Seop ; Lee, Seung Ku ; Shin, Chol. / Visceral adiposity and skeletal muscle mass are independently and synergistically associated with left ventricular structure and function : The Korean Genome and Epidemiology Study. In: International Journal of Cardiology. 2014 ; Vol. 176, No. 3. pp. 951-955.
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title = "Visceral adiposity and skeletal muscle mass are independently and synergistically associated with left ventricular structure and function: The Korean Genome and Epidemiology Study",
abstract = "Conclusions More visceral fat and less muscle mass are independently and synergistically associated with an increase in LV mass index and impairment of LV diastolic parameters. Further research is needed to explore the complex mechanisms underlying these associations.Methods A total of 1941 participants without known cardiovascular disease were enrolled from the Korean Genome and Epidemiology Study. Visceral fat area (VFA) was assessed by computed tomography. Appendicular skeletal muscle mass (ASM) was estimated by dual-energy X-ray absorptiometry and was used as a percentage of body weight (ASM/Wt). LV structure and function were assessed by tissue Doppler imaging (TDI) echocardiography.Results Across VFA tertiles, ASM increased, but ASM/Wt decreased (all P < 0.001). In multivariate models adjusted for conventional cardiovascular risk factors, LV mass index and LV diastolic parameters, such as left atrial dimension, TDI Ea velocity, and E/Ea ratio, were significantly impaired as VFA increased. On the other hand, an increase in ASM/Wt was associated with a decrease in LV mass index and improvement of LV diastolic parameters. With regard to LV mass index and TDI Ea velocity, VFA and ASM/Wt showed synergistic effects (all P interaction < 0.05). When both VFA and ASM/Wt were simultaneously included in the same model, both remained independent predictors of LV mass index and TDI Ea velocity.Background Obesity and low muscle mass may coexist as age-related changes in body composition. We aimed to investigate the effect of visceral adiposity and skeletal muscle mass on left ventricular (LV) structure and function in the general population.",
keywords = "Diastole, Echocardiography, Epidemiology, Left ventricular mass, Skeletal muscle mass, Visceral adiposity",
author = "Juri Park and Kim, {Nan Hee} and Kim, {Seong Hwan} and Kim, {Jin Seok} and Kim, {Yong Hyun} and Lim, {Hong Euy} and Kim, {Eung Ju} and Na, {Jin Oh} and Cho, {Goo Yeong} and Inkyung Baik and Kim, {Doo Man} and Choi, {Dong Seop} and Lee, {Seung Ku} and Chol Shin",
year = "2014",
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Visceral adiposity and skeletal muscle mass are independently and synergistically associated with left ventricular structure and function : The Korean Genome and Epidemiology Study. / Park, Juri; Kim, Nan Hee; Kim, Seong Hwan; Kim, Jin Seok; Kim, Yong Hyun; Lim, Hong Euy; Kim, Eung Ju; Na, Jin Oh; Cho, Goo Yeong; Baik, Inkyung; Kim, Doo Man; Choi, Dong Seop; Lee, Seung Ku; Shin, Chol.

In: International Journal of Cardiology, Vol. 176, No. 3, 20.10.2014, p. 951-955.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Visceral adiposity and skeletal muscle mass are independently and synergistically associated with left ventricular structure and function

T2 - The Korean Genome and Epidemiology Study

AU - Park, Juri

AU - Kim, Nan Hee

AU - Kim, Seong Hwan

AU - Kim, Jin Seok

AU - Kim, Yong Hyun

AU - Lim, Hong Euy

AU - Kim, Eung Ju

AU - Na, Jin Oh

AU - Cho, Goo Yeong

AU - Baik, Inkyung

AU - Kim, Doo Man

AU - Choi, Dong Seop

AU - Lee, Seung Ku

AU - Shin, Chol

PY - 2014/10/20

Y1 - 2014/10/20

N2 - Conclusions More visceral fat and less muscle mass are independently and synergistically associated with an increase in LV mass index and impairment of LV diastolic parameters. Further research is needed to explore the complex mechanisms underlying these associations.Methods A total of 1941 participants without known cardiovascular disease were enrolled from the Korean Genome and Epidemiology Study. Visceral fat area (VFA) was assessed by computed tomography. Appendicular skeletal muscle mass (ASM) was estimated by dual-energy X-ray absorptiometry and was used as a percentage of body weight (ASM/Wt). LV structure and function were assessed by tissue Doppler imaging (TDI) echocardiography.Results Across VFA tertiles, ASM increased, but ASM/Wt decreased (all P < 0.001). In multivariate models adjusted for conventional cardiovascular risk factors, LV mass index and LV diastolic parameters, such as left atrial dimension, TDI Ea velocity, and E/Ea ratio, were significantly impaired as VFA increased. On the other hand, an increase in ASM/Wt was associated with a decrease in LV mass index and improvement of LV diastolic parameters. With regard to LV mass index and TDI Ea velocity, VFA and ASM/Wt showed synergistic effects (all P interaction < 0.05). When both VFA and ASM/Wt were simultaneously included in the same model, both remained independent predictors of LV mass index and TDI Ea velocity.Background Obesity and low muscle mass may coexist as age-related changes in body composition. We aimed to investigate the effect of visceral adiposity and skeletal muscle mass on left ventricular (LV) structure and function in the general population.

AB - Conclusions More visceral fat and less muscle mass are independently and synergistically associated with an increase in LV mass index and impairment of LV diastolic parameters. Further research is needed to explore the complex mechanisms underlying these associations.Methods A total of 1941 participants without known cardiovascular disease were enrolled from the Korean Genome and Epidemiology Study. Visceral fat area (VFA) was assessed by computed tomography. Appendicular skeletal muscle mass (ASM) was estimated by dual-energy X-ray absorptiometry and was used as a percentage of body weight (ASM/Wt). LV structure and function were assessed by tissue Doppler imaging (TDI) echocardiography.Results Across VFA tertiles, ASM increased, but ASM/Wt decreased (all P < 0.001). In multivariate models adjusted for conventional cardiovascular risk factors, LV mass index and LV diastolic parameters, such as left atrial dimension, TDI Ea velocity, and E/Ea ratio, were significantly impaired as VFA increased. On the other hand, an increase in ASM/Wt was associated with a decrease in LV mass index and improvement of LV diastolic parameters. With regard to LV mass index and TDI Ea velocity, VFA and ASM/Wt showed synergistic effects (all P interaction < 0.05). When both VFA and ASM/Wt were simultaneously included in the same model, both remained independent predictors of LV mass index and TDI Ea velocity.Background Obesity and low muscle mass may coexist as age-related changes in body composition. We aimed to investigate the effect of visceral adiposity and skeletal muscle mass on left ventricular (LV) structure and function in the general population.

KW - Diastole

KW - Echocardiography

KW - Epidemiology

KW - Left ventricular mass

KW - Skeletal muscle mass

KW - Visceral adiposity

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U2 - 10.1016/j.ijcard.2014.08.108

DO - 10.1016/j.ijcard.2014.08.108

M3 - Article

VL - 176

SP - 951

EP - 955

JO - International Journal of Cardiology

JF - International Journal of Cardiology

SN - 0167-5273

IS - 3

ER -