Variable phenotype of Pierson syndrome

Hyun Jin Choi, Beom Hee Lee, Ju Hyung Kang, Hyoen Joo Jeong, Kyung Chul Moon, Il Soo Ha, Young Suk Yu, Verena Matejas, Martin Zenker, Yong Choi, Hae Il Cheong

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

Pierson syndrome is caused by mutations in the LAMB2 gene, which encodes the laminin β2 chain, and is clinically characterized by congenital nephrotic syndrome (CNS) and bilateral microcoria. Here, we describe two cases of Pierson syndrome involving atypical phenotypes. Patient 1 presented with congenital microcoria and infantile nephrotic syndrome. Despite persistent nephrotic syndrome, her renal function was maintained normally until she was 6 years old. Genetic analysis revealed two frame-shifting deletions (truncating mutations) in the LAMB2 gene. Patient 2 presented with isolated CNS without ocular involvement. Her renal function deteriorated progressively over several months, and retinal detachment in the right eye developed when she was aged 10 months. LAMB2 analysis revealed a missense mutation in one allele and a frame-shifting deletion in the other allele. Electron microscopy of a renal biopsy revealed irregular lamellation of the glomerular basement membrane (GBM) in both patients. The phenotypes of Pierson syndrome vary widely, and the severity of the renal phenotype is not always parallel to that of the ocular phenotype. The phenotypic variability likely reflects genotype-phenotype correlations, but unknown genetic or environmental modifiers may play an additional role. Ultrastructural changes of the GBM are a useful diagnostic indicator.

Original languageEnglish
Pages (from-to)995-1000
Number of pages6
JournalPediatric Nephrology
Volume23
Issue number6
DOIs
StatePublished - Jun 2008

Keywords

  • Congenital nephrotic syndrome
  • Glomerular basement membrane
  • LAMB2 gene
  • Laminin β2chain
  • Microcoria
  • Pierson syndrome

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