Update on low-density lipoprotein cholesterol quantification

Research output: Contribution to journalReview article

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Purpose of reviewβ-Quantification is considered the reference measurement procedure for low-density lipoprotein cholesterol (LDL-C). However, this technique is time-consuming and thus is inappropriate for routine clinical practice. Therefore, the Friedewald equation or homogeneous assays have been widely utilized. As several pitfalls exist with these two methods, a novel method for estimating LDL-C was developed by Martin et al.Recent findingsMartin's method uses a strata-specific median for the triglycerides/very low-density lipoprotein cholesterol (VLDL-C) ratio on the basis of triglycerides and non-HDL-C concentrations. Recent studies show that Martin's method better correlates with β-quantification or homogeneous assays compared with the Friedewald equation, especially with values of triglycerides at least 150mg/dl and/or LDL-CD less than 70mg/dl. Such findings have also been demonstrated in other ethnic groups (Japanese and Korean) and disease populations, including diabetes and cardiovascular disease, in which the triglycerides/VLDL-C ratio can be affected.SummaryFor the current therapeutic goal of LDL-C values below 70mg/dl in high-risk patients, accurate assessment of LDL-C levels at very low levels is required. Martin's method could overcome pitfalls such as underestimation of the Friedewald equation at this level. Further evaluation of the triglycerides/VLDL-C ratio in participants with diverse ethnic backgrounds or clinical conditions would expand the implementation of this novel method.

Original languageEnglish
Pages (from-to)273-283
Number of pages11
JournalCurrent Opinion in Lipidology
Issue number4
StatePublished - 1 Aug 2019


  • Friedewald equation
  • Martin's method
  • homogeneous assay
  • low-density lipoprotein cholesterol
  • β-Quantification

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