Unusual CD4+CD28 T cells and their pathogenic role in chronic inflammatory disorders

Ga Hye Lee, Won Woo Lee

Research output: Contribution to journalReview articlepeer-review

24 Scopus citations

Abstract

CD28 is a primary co-stimulatory receptor that is essential for successful T cell activation, proliferation, and survival. While ubiquitously expressed on naive T cells, the level of CD28 expression on memory T cells is largely dependent on the T-cell differentiation stage in humans. Expansion of circulating T cells lacking CD28 was originally considered a hallmark of age-associated immunological changes in humans, with a progressive loss of CD28 following replicative senescence with advancing age. However, an increasing body of evidence has revealed that there is a significant age-inappropriate expansion of CD4+CD28 T cells in patients with a variety of chronic inflammatory diseases, suggesting that these cells play a role in their pathogenesis. In fact, expanded CD4+CD28 T cells can produce large amounts of proinflammatory cytokines such as IFN-γ and TNF-α and also have cytotoxic potential, which may cause tissue damage and development of pathogenesis in many inflammatory disorders. Here we review the characteristics of CD4+CD28 T cells as well as the recent advances highlighting the contribution of these cells to several disease conditions.

Original languageEnglish
Pages (from-to)322-329
Number of pages8
JournalImmune Network
Volume16
Issue number6
DOIs
StatePublished - 2016

Bibliographical note

Publisher Copyright:
© 2017, Korean Association of Immunologists. All rights reserved.

Keywords

  • CD28
  • CD4CD28 T cells
  • Chronic inflammatory diseases
  • Co-stimulatory receptor
  • Cytotoxic potential

Fingerprint

Dive into the research topics of 'Unusual CD4+CD28 T cells and their pathogenic role in chronic inflammatory disorders'. Together they form a unique fingerprint.

Cite this