Underlying microstructure of parapapillary deep-layer capillary dropout identified by optical coherence tomography angiography

Eun Ji Lee, Tae Woo Kim, Seung Hyen Lee, Jung Ah Kim

Research output: Contribution to journalArticle

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Abstract

PURPOSE. To characterize the microstructure underlying the parapapillary deep-layer microvasculature dropout (MvD) identified by optical coherence tomography (OCT) angiography (OCTA) in eyes with primary open-angle glaucoma (POAG). METHODS. Parapapillary MvD was defined as a focal sectoral capillary dropout without any visible microvascular network identified in deep-layer en face images obtained using swept-source OCTA. The peripapillary microstructure was characterized in 188 POAG patients with MvD in the parapapillary deep layer. Twelve radial optic nerve images were obtained using swept-source OCT to examine the peripapillary structure and measure the juxtapapillary choroidal thickness (JPCT). The JPCT was also measured in 72 age-matched POAG eyes having β-zone parapapillary atrophy (PPA) without an MvD (control group). RESULTS. Microvascular dropouts were observed within the areas with a PPA involving the β-zone, γ-zone, and a mixture of both zones in 72, 57, and 59 eyes, respectively. Choroid of noticeable thickness was observed without obvious thinning in the PPA area when the MvD was associated with the β-zone. The JPCT was comparable between eyes with MvD and control eyes. There was no distinguishable feature in the microstructure of the γ-zone, regardless of whether it was associated with MvD. CONCLUSIONS. Optical coherence tomography angiography showed MvDs in the parapapillary deep layers that were associated with both β- and γ-zones within the PPAs. The microstructure of PPAs with MvDs was not distinguishable from that of PPAs not associated with MvDs.

Original languageEnglish
Pages (from-to)1621-1627
Number of pages7
JournalInvestigative Ophthalmology and Visual Science
Volume58
Issue number3
DOIs
StatePublished - Mar 2017

Keywords

  • Microvasculature dropout
  • Optical coherence tomography angiography
  • Parapapillary atrophy
  • Primary open-angle glaucoma

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