TRPC1 as a negative regulator for TRPC4 and TRPC5 channels

Jinsung Kim, Juyeon Ko, Jongyun Myeong, Misun Kwak, Chansik Hong, Insuk So

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations


Transient receptor potential canonical (TRPC) channels are calcium permeable, non-selective cation channels with wide tissue-specific distribution. Among 7 TRPC channels, TRPC 1/4/5 and TRPC3/6/7 are subdivided based on amino acid sequence homology. TRPC4 and TRPC5 channels exhibit cationic current with homotetrameric form, but they also form heterotetrameric channel such as TRPC1/4 or TRPC1/5 once TRPC1 is incorporated. The expression of TRPC1 is ubiquitous whereas the expressions of TRPC4 and TRPC5 are rather focused in nervous system. With the help of conditional knock-out of TPRC1, 4 and/or 5 genes, TRPC channels made of these constituents are reported to be involved in various pathophysiological functions such as seizure, anxiety-like behaviour, fear, Huntington’s disease, Parkinson’s disease and many others. In heterologous expression system, many issues such as activation mechanism, stoichiometry and relative cation permeabilites of homomeric or heteromeric channels have been addressed. In this review, we discussed the role of TRPC1 channel per se in plasma membrane, role of TRPC1 in heterotetrameric conformation (TRPC1/4 or TRPC1/5) and relationship between TRPC1/4/5 channels, calcium influx and voltage-gated calcium channels.

Original languageEnglish
Pages (from-to)1045-1053
Number of pages9
JournalPflugers Archiv European Journal of Physiology
Issue number8
StatePublished - 1 Aug 2019


  • Heteromerization
  • TRPC1 channel
  • TRPC4 channel
  • TRPC5 channel
  • Transient receptor potential canonical (TRPC) channel


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