Trends of human papillomavirus-related head and neck cancers in Korea: National cancer registry data

Aesun Shin, Yuh S. Jung, Kyu Won Jung, Kyeezu Kim, Junsun Ryu, Young Joo Won

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Objectives/Hypothesis The incidence of human papillomavirus (HPV)-positive head and neck cancers (HNCs) is increasing sharply worldwide, while their HPV-negative counterparts are showing a decreased frequency. However, epidemiologic data related to these changes are sparse in Korea, which is rapidly adopting more westernized lifestyles. Study Design Data from the Korea Central Cancer Registry, a nationwide population-based cancer registry, from 1999 to 2009 were retrieved. Methods Age-standardized rates (ASRs), their annual percent changes (APC) and male-to-female incidence rate ratios (IRRs) were analyzed and compared between HPV-related and HPV-unrelated primary sites. Results HPV-related sites (oropharynx) had increased significantly over the period 1999 to 2009 (APC = 2.35%, P = 0.017), particularly in young men (30-59 years, APC = 2.65%, P = 0.031), whereas HPV-unrelated sites such as larynx and hypopharynx decreased markedly in both sexes. Interestingly, tongue cancer was found to have increased gradually (APC = 2.35%, P = 0.003) in both sexes. The male-to-female IRRs and the median age of occurrence remained stable. Conclusions Although the cultural and ethnic background differs from the United States, cancers of HPV-related sites are increasing in Korea, whereas cancers of HPV-unrelated sites are decreasing, which is similar to the trends observed in the United States. Greater public awareness in Korea of HPV-related HNCs is therefore warranted.

Original languageEnglish
JournalLaryngoscope
Volume123
Issue number11
DOIs
StatePublished - 1 Nov 2013

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Korea
Head and Neck Neoplasms
Registries
Neoplasms
Incidence
Tongue Neoplasms
Hypopharynx
Oropharynx
Larynx
Life Style

Keywords

  • Head and neck neoplasms
  • Korea
  • cancer registry
  • human papillomavirus
  • incidence
  • oral cancer
  • oropharyngeal neoplasms
  • smoking

Cite this

Shin, Aesun ; Jung, Yuh S. ; Jung, Kyu Won ; Kim, Kyeezu ; Ryu, Junsun ; Won, Young Joo. / Trends of human papillomavirus-related head and neck cancers in Korea : National cancer registry data. In: Laryngoscope. 2013 ; Vol. 123, No. 11.
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abstract = "Objectives/Hypothesis The incidence of human papillomavirus (HPV)-positive head and neck cancers (HNCs) is increasing sharply worldwide, while their HPV-negative counterparts are showing a decreased frequency. However, epidemiologic data related to these changes are sparse in Korea, which is rapidly adopting more westernized lifestyles. Study Design Data from the Korea Central Cancer Registry, a nationwide population-based cancer registry, from 1999 to 2009 were retrieved. Methods Age-standardized rates (ASRs), their annual percent changes (APC) and male-to-female incidence rate ratios (IRRs) were analyzed and compared between HPV-related and HPV-unrelated primary sites. Results HPV-related sites (oropharynx) had increased significantly over the period 1999 to 2009 (APC = 2.35{\%}, P = 0.017), particularly in young men (30-59 years, APC = 2.65{\%}, P = 0.031), whereas HPV-unrelated sites such as larynx and hypopharynx decreased markedly in both sexes. Interestingly, tongue cancer was found to have increased gradually (APC = 2.35{\%}, P = 0.003) in both sexes. The male-to-female IRRs and the median age of occurrence remained stable. Conclusions Although the cultural and ethnic background differs from the United States, cancers of HPV-related sites are increasing in Korea, whereas cancers of HPV-unrelated sites are decreasing, which is similar to the trends observed in the United States. Greater public awareness in Korea of HPV-related HNCs is therefore warranted.",
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Trends of human papillomavirus-related head and neck cancers in Korea : National cancer registry data. / Shin, Aesun; Jung, Yuh S.; Jung, Kyu Won; Kim, Kyeezu; Ryu, Junsun; Won, Young Joo.

In: Laryngoscope, Vol. 123, No. 11, 01.11.2013.

Research output: Contribution to journalArticle

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T1 - Trends of human papillomavirus-related head and neck cancers in Korea

T2 - National cancer registry data

AU - Shin, Aesun

AU - Jung, Yuh S.

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