Trends in the distribution and antimicrobial susceptibility of causative pathogens of device-associated infection in Korean intensive care units from 2006 to 2013: results from the Korean Nosocomial Infections Surveillance System (KONIS)

Korean Nosocomial Infections Surveillance System (KONIS)

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Abstract

Background For all countries, information on pathogens causing healthcare-associated infections is important in order to develop proper strategies for preventing and treating nosocomial infections. Aim To assess the change in frequencies and antimicrobial resistance of pathogens causing device-associated infections (DAIs) in intensive care units (ICUs) in South Korea between July 2006 and June 2014. Methods Data from the Korean Nosocomial Infections Surveillance System (KONIS) were analysed, including three major DAI types in ICUs. Findings The frequency of Gram-negative bacteria gradually increased for central line-associated bloodstream infection (CLABSI) and ventilator-associated pneumonia (VAP) (from 24.6% to 32.6% and from 52.8% to 73.5%, respectively). By contrast, the frequency of Gram-positive bacteria decreased from 58.6% to 49.2% for CLABSI, and from 44.3% to 23.8% for VAP (P < 0.001). Staphylococcus aureus was the most frequent causative pathogen in CLABSI throughout the surveillance period, but for VAP was replaced as the most frequent pathogen by Acinetobacter baumannii as of 2010. Candida albicans was the most frequent pathogen for catheter-associated urinary tract infection. The meticillin resistance rate in S. aureus decreased from 95% to 90.2% (P < 0.001); amikacin resistance in Klebsiella pneumoniae and Escherichia coli decreased from 43.8% to 14.7% and from 15.0% to 1.8%, respectively (P < 0.001); imipenem resistance in A. baumannii increased from 52.9% to 89.8% (P < 0.001). Conclusion The proportion of Gram-negative bacteria as nosocomial pathogens for CLABSI and VAP has increased. The prevalence of A. baumannii causing DAIs in Korean ICUs has increased rapidly, as has the rate of carbapenem resistance in these bacteria.

Original languageEnglish
Pages (from-to)363-371
Number of pages9
JournalJournal of Hospital Infection
Volume92
Issue number4
DOIs
StatePublished - 1 Apr 2016

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Cross Infection
Intensive Care Units
Ventilator-Associated Pneumonia
Equipment and Supplies
Infection
Gram-Negative Bacteria
Catheter-Related Infections
Acinetobacter baumannii
Republic of Korea
Carbapenems
Methicillin
Amikacin
Imipenem
Klebsiella pneumoniae
Gram-Positive Bacteria
Candida albicans
Urinary Tract Infections
Staphylococcus aureus
Escherichia coli
Bacteria

Keywords

  • Device-associated infections
  • Healthcare-associated infection
  • Pathogen
  • Resistance
  • Surveillance

Cite this

@article{4e6d60b6c8914d7b9a3782557274394a,
title = "Trends in the distribution and antimicrobial susceptibility of causative pathogens of device-associated infection in Korean intensive care units from 2006 to 2013: results from the Korean Nosocomial Infections Surveillance System (KONIS)",
abstract = "Background For all countries, information on pathogens causing healthcare-associated infections is important in order to develop proper strategies for preventing and treating nosocomial infections. Aim To assess the change in frequencies and antimicrobial resistance of pathogens causing device-associated infections (DAIs) in intensive care units (ICUs) in South Korea between July 2006 and June 2014. Methods Data from the Korean Nosocomial Infections Surveillance System (KONIS) were analysed, including three major DAI types in ICUs. Findings The frequency of Gram-negative bacteria gradually increased for central line-associated bloodstream infection (CLABSI) and ventilator-associated pneumonia (VAP) (from 24.6{\%} to 32.6{\%} and from 52.8{\%} to 73.5{\%}, respectively). By contrast, the frequency of Gram-positive bacteria decreased from 58.6{\%} to 49.2{\%} for CLABSI, and from 44.3{\%} to 23.8{\%} for VAP (P < 0.001). Staphylococcus aureus was the most frequent causative pathogen in CLABSI throughout the surveillance period, but for VAP was replaced as the most frequent pathogen by Acinetobacter baumannii as of 2010. Candida albicans was the most frequent pathogen for catheter-associated urinary tract infection. The meticillin resistance rate in S. aureus decreased from 95{\%} to 90.2{\%} (P < 0.001); amikacin resistance in Klebsiella pneumoniae and Escherichia coli decreased from 43.8{\%} to 14.7{\%} and from 15.0{\%} to 1.8{\%}, respectively (P < 0.001); imipenem resistance in A. baumannii increased from 52.9{\%} to 89.8{\%} (P < 0.001). Conclusion The proportion of Gram-negative bacteria as nosocomial pathogens for CLABSI and VAP has increased. The prevalence of A. baumannii causing DAIs in Korean ICUs has increased rapidly, as has the rate of carbapenem resistance in these bacteria.",
keywords = "Device-associated infections, Healthcare-associated infection, Pathogen, Resistance, Surveillance",
author = "{Korean Nosocomial Infections Surveillance System (KONIS)} and Choi, {J. Y.} and Kwak, {Y. G.} and H. Yoo and Lee, {S. O.} and Kim, {Hong Bin} and Han, {S. H.} and Choi, {H. J.} and Kim, {H. Y.} and Kim, {S. R.} and Kim, {T. H.} and H. Lee and Chun, {H. K.} and Kim, {J. S.} and Eun, {B. W.} and Kim, {D. W.} and Koo, {H. S.} and Cho, {E. H.} and K. Lee",
year = "2016",
month = "4",
day = "1",
doi = "10.1016/j.jhin.2015.12.012",
language = "English",
volume = "92",
pages = "363--371",
journal = "Journal of Hospital Infection",
issn = "0195-6701",
publisher = "W.B. Saunders Ltd",
number = "4",

}

TY - JOUR

T1 - Trends in the distribution and antimicrobial susceptibility of causative pathogens of device-associated infection in Korean intensive care units from 2006 to 2013

T2 - results from the Korean Nosocomial Infections Surveillance System (KONIS)

AU - Korean Nosocomial Infections Surveillance System (KONIS)

AU - Choi, J. Y.

AU - Kwak, Y. G.

AU - Yoo, H.

AU - Lee, S. O.

AU - Kim, Hong Bin

AU - Han, S. H.

AU - Choi, H. J.

AU - Kim, H. Y.

AU - Kim, S. R.

AU - Kim, T. H.

AU - Lee, H.

AU - Chun, H. K.

AU - Kim, J. S.

AU - Eun, B. W.

AU - Kim, D. W.

AU - Koo, H. S.

AU - Cho, E. H.

AU - Lee, K.

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Background For all countries, information on pathogens causing healthcare-associated infections is important in order to develop proper strategies for preventing and treating nosocomial infections. Aim To assess the change in frequencies and antimicrobial resistance of pathogens causing device-associated infections (DAIs) in intensive care units (ICUs) in South Korea between July 2006 and June 2014. Methods Data from the Korean Nosocomial Infections Surveillance System (KONIS) were analysed, including three major DAI types in ICUs. Findings The frequency of Gram-negative bacteria gradually increased for central line-associated bloodstream infection (CLABSI) and ventilator-associated pneumonia (VAP) (from 24.6% to 32.6% and from 52.8% to 73.5%, respectively). By contrast, the frequency of Gram-positive bacteria decreased from 58.6% to 49.2% for CLABSI, and from 44.3% to 23.8% for VAP (P < 0.001). Staphylococcus aureus was the most frequent causative pathogen in CLABSI throughout the surveillance period, but for VAP was replaced as the most frequent pathogen by Acinetobacter baumannii as of 2010. Candida albicans was the most frequent pathogen for catheter-associated urinary tract infection. The meticillin resistance rate in S. aureus decreased from 95% to 90.2% (P < 0.001); amikacin resistance in Klebsiella pneumoniae and Escherichia coli decreased from 43.8% to 14.7% and from 15.0% to 1.8%, respectively (P < 0.001); imipenem resistance in A. baumannii increased from 52.9% to 89.8% (P < 0.001). Conclusion The proportion of Gram-negative bacteria as nosocomial pathogens for CLABSI and VAP has increased. The prevalence of A. baumannii causing DAIs in Korean ICUs has increased rapidly, as has the rate of carbapenem resistance in these bacteria.

AB - Background For all countries, information on pathogens causing healthcare-associated infections is important in order to develop proper strategies for preventing and treating nosocomial infections. Aim To assess the change in frequencies and antimicrobial resistance of pathogens causing device-associated infections (DAIs) in intensive care units (ICUs) in South Korea between July 2006 and June 2014. Methods Data from the Korean Nosocomial Infections Surveillance System (KONIS) were analysed, including three major DAI types in ICUs. Findings The frequency of Gram-negative bacteria gradually increased for central line-associated bloodstream infection (CLABSI) and ventilator-associated pneumonia (VAP) (from 24.6% to 32.6% and from 52.8% to 73.5%, respectively). By contrast, the frequency of Gram-positive bacteria decreased from 58.6% to 49.2% for CLABSI, and from 44.3% to 23.8% for VAP (P < 0.001). Staphylococcus aureus was the most frequent causative pathogen in CLABSI throughout the surveillance period, but for VAP was replaced as the most frequent pathogen by Acinetobacter baumannii as of 2010. Candida albicans was the most frequent pathogen for catheter-associated urinary tract infection. The meticillin resistance rate in S. aureus decreased from 95% to 90.2% (P < 0.001); amikacin resistance in Klebsiella pneumoniae and Escherichia coli decreased from 43.8% to 14.7% and from 15.0% to 1.8%, respectively (P < 0.001); imipenem resistance in A. baumannii increased from 52.9% to 89.8% (P < 0.001). Conclusion The proportion of Gram-negative bacteria as nosocomial pathogens for CLABSI and VAP has increased. The prevalence of A. baumannii causing DAIs in Korean ICUs has increased rapidly, as has the rate of carbapenem resistance in these bacteria.

KW - Device-associated infections

KW - Healthcare-associated infection

KW - Pathogen

KW - Resistance

KW - Surveillance

UR - http://www.scopus.com/inward/record.url?scp=84971476621&partnerID=8YFLogxK

U2 - 10.1016/j.jhin.2015.12.012

DO - 10.1016/j.jhin.2015.12.012

M3 - Article

C2 - 26876746

AN - SCOPUS:84971476621

VL - 92

SP - 363

EP - 371

JO - Journal of Hospital Infection

JF - Journal of Hospital Infection

SN - 0195-6701

IS - 4

ER -