Trend-based analysis of retinal nerve fiber layer thickness measured by optical coherence tomography in eyes with localized nerve fiber layer defects

Eun Ji Lee, Tae Woo Kim, Robert N. Weinreb, Ki Ho Park, Seok Hwan Kim, Dong Myung Kim

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

PURPOSE. To evaluate the rate of change in retinal nerve fiber layer (RNFL) thickness measured by optical coherence tomography (OCT) in eyes with stable and progressive localized RNFL defects and to investigate, in a trend-based approach, the diagnostic capability of OCT in the detection of progressive RNFL thinning. METHODS. The study included 153 glaucomatous eyes with localized RNFL defects. The patients were divided into nonprogressors (n = 77) and progressors (n = 76) on the basis of an evaluation of serial red-free photographs. The rates of progressive thinning in global, quadrant, and clock-hour OCT RNFL thicknesses were determined, by linear regression, and were compared between groups. Areas under receiver operating characteristic curves and sensitivities at fixed specificities were calculated for each parameter. RESULTS. The rate of progressive RNFL thinning was significantly faster in progressors than in nonprogressors globally; in the inferior quadrant; in the 10, 11, 6, and 7 o'clock sectors; and in the affected quadrant and clock-hour sector thicknesses (all P ≤ 0.001). The rate of RNFL thinning in affected clockhour sectors had the highest ability to discriminate between stable and progressive RNFL thinning with a sensitivity of 62% (95% confidence interval, 50%-73%) at a specificity ≥80%. Agreement between OCT and red-free photography was strongest when the criterion of -3.6 μm/year with P < 0.1 was used for each clock hour. CONCLUSIONS. The rate of OCT RNFL thinning was significantly greater in patients with progressive localized RNFL defects than in those with stable localized defects. The data suggest that trend-based analysis of OCT RNFL thickness may be useful in glaucoma progression analysis and may complement other diagnostic tests.

Original languageEnglish
Pages (from-to)1138-1144
Number of pages7
JournalInvestigative Ophthalmology and Visual Science
Volume52
Issue number2
DOIs
StatePublished - 1 Feb 2011

Fingerprint

Optical Coherence Tomography
Nerve Fibers
Photography
Routine Diagnostic Tests
ROC Curve
Glaucoma
Linear Models
Confidence Intervals

Cite this

@article{4341d8d4d90444f79622e0edd111723e,
title = "Trend-based analysis of retinal nerve fiber layer thickness measured by optical coherence tomography in eyes with localized nerve fiber layer defects",
abstract = "PURPOSE. To evaluate the rate of change in retinal nerve fiber layer (RNFL) thickness measured by optical coherence tomography (OCT) in eyes with stable and progressive localized RNFL defects and to investigate, in a trend-based approach, the diagnostic capability of OCT in the detection of progressive RNFL thinning. METHODS. The study included 153 glaucomatous eyes with localized RNFL defects. The patients were divided into nonprogressors (n = 77) and progressors (n = 76) on the basis of an evaluation of serial red-free photographs. The rates of progressive thinning in global, quadrant, and clock-hour OCT RNFL thicknesses were determined, by linear regression, and were compared between groups. Areas under receiver operating characteristic curves and sensitivities at fixed specificities were calculated for each parameter. RESULTS. The rate of progressive RNFL thinning was significantly faster in progressors than in nonprogressors globally; in the inferior quadrant; in the 10, 11, 6, and 7 o'clock sectors; and in the affected quadrant and clock-hour sector thicknesses (all P ≤ 0.001). The rate of RNFL thinning in affected clockhour sectors had the highest ability to discriminate between stable and progressive RNFL thinning with a sensitivity of 62{\%} (95{\%} confidence interval, 50{\%}-73{\%}) at a specificity ≥80{\%}. Agreement between OCT and red-free photography was strongest when the criterion of -3.6 μm/year with P < 0.1 was used for each clock hour. CONCLUSIONS. The rate of OCT RNFL thinning was significantly greater in patients with progressive localized RNFL defects than in those with stable localized defects. The data suggest that trend-based analysis of OCT RNFL thickness may be useful in glaucoma progression analysis and may complement other diagnostic tests.",
author = "Lee, {Eun Ji} and Kim, {Tae Woo} and Weinreb, {Robert N.} and Park, {Ki Ho} and Kim, {Seok Hwan} and Kim, {Dong Myung}",
year = "2011",
month = "2",
day = "1",
doi = "10.1167/iovs.10-5975",
language = "English",
volume = "52",
pages = "1138--1144",
journal = "Investigative Ophthalmology and Visual Science",
issn = "0146-0404",
publisher = "Association for Research in Vision and Ophthalmology Inc.",
number = "2",

}

TY - JOUR

T1 - Trend-based analysis of retinal nerve fiber layer thickness measured by optical coherence tomography in eyes with localized nerve fiber layer defects

AU - Lee, Eun Ji

AU - Kim, Tae Woo

AU - Weinreb, Robert N.

AU - Park, Ki Ho

AU - Kim, Seok Hwan

AU - Kim, Dong Myung

PY - 2011/2/1

Y1 - 2011/2/1

N2 - PURPOSE. To evaluate the rate of change in retinal nerve fiber layer (RNFL) thickness measured by optical coherence tomography (OCT) in eyes with stable and progressive localized RNFL defects and to investigate, in a trend-based approach, the diagnostic capability of OCT in the detection of progressive RNFL thinning. METHODS. The study included 153 glaucomatous eyes with localized RNFL defects. The patients were divided into nonprogressors (n = 77) and progressors (n = 76) on the basis of an evaluation of serial red-free photographs. The rates of progressive thinning in global, quadrant, and clock-hour OCT RNFL thicknesses were determined, by linear regression, and were compared between groups. Areas under receiver operating characteristic curves and sensitivities at fixed specificities were calculated for each parameter. RESULTS. The rate of progressive RNFL thinning was significantly faster in progressors than in nonprogressors globally; in the inferior quadrant; in the 10, 11, 6, and 7 o'clock sectors; and in the affected quadrant and clock-hour sector thicknesses (all P ≤ 0.001). The rate of RNFL thinning in affected clockhour sectors had the highest ability to discriminate between stable and progressive RNFL thinning with a sensitivity of 62% (95% confidence interval, 50%-73%) at a specificity ≥80%. Agreement between OCT and red-free photography was strongest when the criterion of -3.6 μm/year with P < 0.1 was used for each clock hour. CONCLUSIONS. The rate of OCT RNFL thinning was significantly greater in patients with progressive localized RNFL defects than in those with stable localized defects. The data suggest that trend-based analysis of OCT RNFL thickness may be useful in glaucoma progression analysis and may complement other diagnostic tests.

AB - PURPOSE. To evaluate the rate of change in retinal nerve fiber layer (RNFL) thickness measured by optical coherence tomography (OCT) in eyes with stable and progressive localized RNFL defects and to investigate, in a trend-based approach, the diagnostic capability of OCT in the detection of progressive RNFL thinning. METHODS. The study included 153 glaucomatous eyes with localized RNFL defects. The patients were divided into nonprogressors (n = 77) and progressors (n = 76) on the basis of an evaluation of serial red-free photographs. The rates of progressive thinning in global, quadrant, and clock-hour OCT RNFL thicknesses were determined, by linear regression, and were compared between groups. Areas under receiver operating characteristic curves and sensitivities at fixed specificities were calculated for each parameter. RESULTS. The rate of progressive RNFL thinning was significantly faster in progressors than in nonprogressors globally; in the inferior quadrant; in the 10, 11, 6, and 7 o'clock sectors; and in the affected quadrant and clock-hour sector thicknesses (all P ≤ 0.001). The rate of RNFL thinning in affected clockhour sectors had the highest ability to discriminate between stable and progressive RNFL thinning with a sensitivity of 62% (95% confidence interval, 50%-73%) at a specificity ≥80%. Agreement between OCT and red-free photography was strongest when the criterion of -3.6 μm/year with P < 0.1 was used for each clock hour. CONCLUSIONS. The rate of OCT RNFL thinning was significantly greater in patients with progressive localized RNFL defects than in those with stable localized defects. The data suggest that trend-based analysis of OCT RNFL thickness may be useful in glaucoma progression analysis and may complement other diagnostic tests.

UR - http://www.scopus.com/inward/record.url?scp=79953267559&partnerID=8YFLogxK

U2 - 10.1167/iovs.10-5975

DO - 10.1167/iovs.10-5975

M3 - Article

C2 - 21051691

AN - SCOPUS:79953267559

VL - 52

SP - 1138

EP - 1144

JO - Investigative Ophthalmology and Visual Science

JF - Investigative Ophthalmology and Visual Science

SN - 0146-0404

IS - 2

ER -