Tranilast-delivery surgical sutures to ameliorate wound healing by reducing scar formation through regulation of TGF-β expression and fibroblast recruitment

Sung Yoon Choi, Byung Hwi Kim, Beom Kang Huh, Woong Jeong, Min Park, Hyo Jin Park, Ji Ho Park, Chan Yeong Heo, Young Bin Choy

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


We describe surgical sutures enabled with the local, sustained delivery of a TGF-β inhibitory drug, tranilast. To fabricate drug-delivery sutures, we separately prepared a tranilast-loaded strand using poly(lactic-co-glycolic acid), which was then physically braided with a surgical suture already in clinical use. By this method, the drug-delivery sutures maintained the mechanical strength and allowed the modulation of drug release profiles by simply altering the tranilast-loaded strand. The drug-delivery sutures herein released tranilast for up to 14 days. When applied to animal models, scarring was indeed reduced with diminished TGF-β expression and fibroblast numbers during the entire 21 day testing period.

Original languageEnglish
Pages (from-to)469-477
Number of pages9
JournalJournal of Industrial and Engineering Chemistry
StatePublished - 25 Nov 2018


  • Fibroblasts
  • Scar reduction
  • Surgical suture
  • Sustained drug delivery
  • TGF-β

Cite this