Tranilast-delivery surgical sutures to ameliorate wound healing by reducing scar formation through regulation of TGF-β expression and fibroblast recruitment

Sung Yoon Choi; Byung Hwi Kim; Beom Kang Huh; Woong Jeong; Min Park; Hyo Jin Park; Ji Ho Park; Chan Yeong Heo; Young Bin Choy

doi:10.1016/j.jiec.2018.07.021

Tranilast-delivery surgical sutures to ameliorate wound healing by reducing scar formation through regulation of TGF-β expression and fibroblast recruitment

Sung Yoon Choi, Byung Hwi Kim, Beom Kang Huh, Woong Jeong, Min Park, Hyo Jin Park, Ji Ho Park, Chan Yeong Heo, Young Bin Choy

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

We describe surgical sutures enabled with the local, sustained delivery of a TGF-β inhibitory drug, tranilast. To fabricate drug-delivery sutures, we separately prepared a tranilast-loaded strand using poly(lactic-co-glycolic acid), which was then physically braided with a surgical suture already in clinical use. By this method, the drug-delivery sutures maintained the mechanical strength and allowed the modulation of drug release profiles by simply altering the tranilast-loaded strand. The drug-delivery sutures herein released tranilast for up to 14 days. When applied to animal models, scarring was indeed reduced with diminished TGF-β expression and fibroblast numbers during the entire 21 day testing period.

Original language	English
Pages (from-to)	469-477
Number of pages	9
Journal	Journal of Industrial and Engineering Chemistry
Volume	67
DOIs	https://doi.org/10.1016/j.jiec.2018.07.021
State	Published - 25 Nov 2018

Keywords

Fibroblasts
Scar reduction
Surgical suture
Sustained drug delivery
TGF-β

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10.1016/j.jiec.2018.07.021

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Choi, S. Y., Kim, B. H., Huh, B. K., Jeong, W., Park, M., Park, H. J., Park, J. H., Heo, C. Y., & Choy, Y. B. (2018). Tranilast-delivery surgical sutures to ameliorate wound healing by reducing scar formation through regulation of TGF-β expression and fibroblast recruitment. Journal of Industrial and Engineering Chemistry, 67, 469-477. https://doi.org/10.1016/j.jiec.2018.07.021

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title = "Tranilast-delivery surgical sutures to ameliorate wound healing by reducing scar formation through regulation of TGF-β expression and fibroblast recruitment",

abstract = "We describe surgical sutures enabled with the local, sustained delivery of a TGF-β inhibitory drug, tranilast. To fabricate drug-delivery sutures, we separately prepared a tranilast-loaded strand using poly(lactic-co-glycolic acid), which was then physically braided with a surgical suture already in clinical use. By this method, the drug-delivery sutures maintained the mechanical strength and allowed the modulation of drug release profiles by simply altering the tranilast-loaded strand. The drug-delivery sutures herein released tranilast for up to 14 days. When applied to animal models, scarring was indeed reduced with diminished TGF-β expression and fibroblast numbers during the entire 21 day testing period.",

keywords = "Fibroblasts, Scar reduction, Surgical suture, Sustained drug delivery, TGF-β",

author = "Choi, {Sung Yoon} and Kim, {Byung Hwi} and Huh, {Beom Kang} and Woong Jeong and Min Park and Park, {Hyo Jin} and Park, {Ji Ho} and Heo, {Chan Yeong} and Choy, {Young Bin}",

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doi = "10.1016/j.jiec.2018.07.021",

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T1 - Tranilast-delivery surgical sutures to ameliorate wound healing by reducing scar formation through regulation of TGF-β expression and fibroblast recruitment

AU - Choi, Sung Yoon

AU - Kim, Byung Hwi

AU - Huh, Beom Kang

AU - Jeong, Woong

AU - Park, Min

AU - Park, Hyo Jin

AU - Park, Ji Ho

AU - Heo, Chan Yeong

AU - Choy, Young Bin

PY - 2018/11/25

Y1 - 2018/11/25

N2 - We describe surgical sutures enabled with the local, sustained delivery of a TGF-β inhibitory drug, tranilast. To fabricate drug-delivery sutures, we separately prepared a tranilast-loaded strand using poly(lactic-co-glycolic acid), which was then physically braided with a surgical suture already in clinical use. By this method, the drug-delivery sutures maintained the mechanical strength and allowed the modulation of drug release profiles by simply altering the tranilast-loaded strand. The drug-delivery sutures herein released tranilast for up to 14 days. When applied to animal models, scarring was indeed reduced with diminished TGF-β expression and fibroblast numbers during the entire 21 day testing period.

AB - We describe surgical sutures enabled with the local, sustained delivery of a TGF-β inhibitory drug, tranilast. To fabricate drug-delivery sutures, we separately prepared a tranilast-loaded strand using poly(lactic-co-glycolic acid), which was then physically braided with a surgical suture already in clinical use. By this method, the drug-delivery sutures maintained the mechanical strength and allowed the modulation of drug release profiles by simply altering the tranilast-loaded strand. The drug-delivery sutures herein released tranilast for up to 14 days. When applied to animal models, scarring was indeed reduced with diminished TGF-β expression and fibroblast numbers during the entire 21 day testing period.

KW - Fibroblasts

KW - Scar reduction

KW - Surgical suture

KW - Sustained drug delivery

KW - TGF-β

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DO - 10.1016/j.jiec.2018.07.021

M3 - Article

AN - SCOPUS:85050863515

SN - 1226-086X

VL - 67

SP - 469

EP - 477

JO - Journal of Industrial and Engineering Chemistry

JF - Journal of Industrial and Engineering Chemistry

ER -

Tranilast-delivery surgical sutures to ameliorate wound healing by reducing scar formation through regulation of TGF-β expression and fibroblast recruitment

Abstract

Keywords

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