We describe surgical sutures enabled with the local, sustained delivery of a TGF-β inhibitory drug, tranilast. To fabricate drug-delivery sutures, we separately prepared a tranilast-loaded strand using poly(lactic-co-glycolic acid), which was then physically braided with a surgical suture already in clinical use. By this method, the drug-delivery sutures maintained the mechanical strength and allowed the modulation of drug release profiles by simply altering the tranilast-loaded strand. The drug-delivery sutures herein released tranilast for up to 14 days. When applied to animal models, scarring was indeed reduced with diminished TGF-β expression and fibroblast numbers during the entire 21 day testing period.
|Number of pages||9|
|Journal||Journal of Industrial and Engineering Chemistry|
|State||Published - 25 Nov 2018|
- Scar reduction
- Surgical suture
- Sustained drug delivery