The ubiquitin-proteasome system in cardiovascular diseases - A hypothesis extended

Joerg Herrmann, Aaron Ciechanover, Lilach O. Lerman, Amir Lerman

Research output: Contribution to journalReview articleResearchpeer-review

145 Citations (Scopus)

Abstract

During recent years, the ubiquitin-proteasome system has become known as the major pathway of non-lysosomal degradation of intracellular proteins, involving two sequential steps. In the first step, multiple moieties of ubiquitin are covalently bound to target proteins to be recognized and degraded by the multi-enzymatic proteasome complex in the second step. In addition to the elimination of damaged and unneeded proteins, this system fulfills an important function in the regulation of cellular mediators in various biological pathways. Foremost, these biological pathways include inflammation, cell proliferation, and apoptosis, all of which constitute important characteristics of atherosclerosis. Indeed, recent experimental evidence supports a potential involvement of the ubiquitin-proteasome system in the initiation, progression, and complication stage of atherogenesis. This review summarizes recent findings regarding the ubiquitin-proteasome system in cardiovascular diseases and discusses the potential use of proteasome inhibitors in cardiovascular therapy.

Original languageEnglish
Pages (from-to)11-21
Number of pages11
JournalCardiovascular Research
Volume61
Issue number1
DOIs
StatePublished - 1 Jan 2004

Fingerprint

Proteasome Endopeptidase Complex
Ubiquitin
Cardiovascular Diseases
Atherosclerosis
Proteasome Inhibitors
Proteolysis
Proteins
Cell Proliferation
Apoptosis
Inflammation
Therapeutics

Keywords

  • Apoptosis
  • Atherosclerosis
  • Coronary disease
  • Restenosis

Cite this

Herrmann, Joerg ; Ciechanover, Aaron ; Lerman, Lilach O. ; Lerman, Amir. / The ubiquitin-proteasome system in cardiovascular diseases - A hypothesis extended. In: Cardiovascular Research. 2004 ; Vol. 61, No. 1. pp. 11-21.
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The ubiquitin-proteasome system in cardiovascular diseases - A hypothesis extended. / Herrmann, Joerg; Ciechanover, Aaron; Lerman, Lilach O.; Lerman, Amir.

In: Cardiovascular Research, Vol. 61, No. 1, 01.01.2004, p. 11-21.

Research output: Contribution to journalReview articleResearchpeer-review

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