The SWI/SNF-like BAF complex is essential for early B cell development

Jinwook Choi, Myunggon Ko, Shin Jeon, Yoon Jeon, Kyungsoo Park, Changjin Lee, Ho Lee, Rho H. Seong

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26 Citations (Scopus)

Abstract

During the process of B cell development, transcription factors, such as E2A and Ebf1, have been known to play key roles. Although transcription factors and chromatin regulators work in concert to direct the expression of B lineage-specific genes, little is known about the involvement of regulators for chromatin structure during B lymphopoiesis. In this article, we show that deletion of Srg3/mBaf155, a scaffold subunit of the SWI/SNF-like BAF complex, in the hematopoietic lineage caused defects at both the common lymphoid progenitor stage and the transition from pre-pro-B to early pro-B cells due to failures in the expression of B lineage-specific genes, such as Ebf1 and Il7ra, and their downstream target genes. Moreover, mice that were deficient in the expression of Brg1, a subunit of the complex with ATPase activity, also showed defects in early B cell development. We also found that the expression of Ebf1 and Il7ra is directly regulated by the SWI/SNF-like BAF complex. Thus, our results suggest that the SWI/SNF-like BAF complex facilitates early B cell development by regulating the expression of B lineage-specific genes.

Original languageEnglish
Pages (from-to)3791-3803
Number of pages13
JournalJournal of Immunology
Volume188
Issue number8
DOIs
StatePublished - 15 Apr 2012

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B-Lymphocytes
Genes
Chromatin
Transcription Factors
Lymphoid Progenitor Cells
Lymphopoiesis
B-Lymphoid Precursor Cells
Adenosine Triphosphatases

Cite this

Choi, J., Ko, M., Jeon, S., Jeon, Y., Park, K., Lee, C., ... Seong, R. H. (2012). The SWI/SNF-like BAF complex is essential for early B cell development. Journal of Immunology, 188(8), 3791-3803. https://doi.org/10.4049/jimmunol.1103390
Choi, Jinwook ; Ko, Myunggon ; Jeon, Shin ; Jeon, Yoon ; Park, Kyungsoo ; Lee, Changjin ; Lee, Ho ; Seong, Rho H. / The SWI/SNF-like BAF complex is essential for early B cell development. In: Journal of Immunology. 2012 ; Vol. 188, No. 8. pp. 3791-3803.
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Choi, J, Ko, M, Jeon, S, Jeon, Y, Park, K, Lee, C, Lee, H & Seong, RH 2012, 'The SWI/SNF-like BAF complex is essential for early B cell development', Journal of Immunology, vol. 188, no. 8, pp. 3791-3803. https://doi.org/10.4049/jimmunol.1103390

The SWI/SNF-like BAF complex is essential for early B cell development. / Choi, Jinwook; Ko, Myunggon; Jeon, Shin; Jeon, Yoon; Park, Kyungsoo; Lee, Changjin; Lee, Ho; Seong, Rho H.

In: Journal of Immunology, Vol. 188, No. 8, 15.04.2012, p. 3791-3803.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Lee, Changjin

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AU - Seong, Rho H.

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