The roles of G proteins in the activation of TRPC4 and TRPC5 transient receptor potential channels

Hana Kim, Jinsung Kim, Jae Pyo Jeon, Jongyun Myeong, Jinhong Wie, Chansik Hong, Hyun Jin Kim, Ju Hong Jeon, Insuk So

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations

Abstract

TRPC4 and TRPC5 channels are important regulators of electrical excitability in both gastrointestinal myocytes and neurons. Much is known regarding the assembly and function of these channels including TRPC1 as a homotetramer or a heteromultimer and the roles that their interacting proteins play in controlling these events. Further, they are one of the best-studied targets of G protein-coupled receptors and growth factors in general and Gáq protein coupled receptor or epidermal growth factor in particular. However, our understanding of the roles of Gαi/o proteins on TRPC4/5 channels is still rudimentary. We discuss potential roles for Gαi/o proteins in channel activation in addition to their known role in cellular signaling.

Original languageEnglish
Pages (from-to)333-343
Number of pages11
JournalChannels
Volume6
Issue number5
DOIs
StatePublished - 2012

Keywords

  • Endothelial cells
  • G proteins
  • GI tract
  • GPCR
  • TRP channel
  • TRPC4
  • TRPC5

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