@article{7460ed0b78724f33ba65b38026f87fb3,
title = "The roles of G proteins in the activation of TRPC4 and TRPC5 transient receptor potential channels",
abstract = "TRPC4 and TRPC5 channels are important regulators of electrical excitability in both gastrointestinal myocytes and neurons. Much is known regarding the assembly and function of these channels including TRPC1 as a homotetramer or a heteromultimer and the roles that their interacting proteins play in controlling these events. Further, they are one of the best-studied targets of G protein-coupled receptors and growth factors in general and G{\'a}q protein coupled receptor or epidermal growth factor in particular. However, our understanding of the roles of Gαi/o proteins on TRPC4/5 channels is still rudimentary. We discuss potential roles for Gαi/o proteins in channel activation in addition to their known role in cellular signaling.",
keywords = "Endothelial cells, G proteins, GI tract, GPCR, TRP channel, TRPC4, TRPC5",
author = "Hana Kim and Jinsung Kim and Jeon, {Jae Pyo} and Jongyun Myeong and Jinhong Wie and Chansik Hong and Kim, {Hyun Jin} and Jeon, {Ju Hong} and Insuk So",
note = "Funding Information: We acknowledge the roles of the Biomedical Imaging Center at the Seoul National University College of Medicine, Seoul, Korea. This study was supported by a grant from the Korea Health 21 R&D project, Ministry of Health, Welfare and Family Affairs, Republic of Korea (A100079) and by the National Research Foundation of Korea funded by the Korean government (MEST) (2008-2005948, 2010-0019472 and 2012R1A2A1A01003073). C.H., J.P.J., J.W. and S.Y.K. were supported by the graduate program of BK21 project from the Ministry of Education, Science and Technology (MEST).",
year = "2012",
doi = "10.4161/chan.21198",
language = "English",
volume = "6",
pages = "333--343",
journal = "Channels",
issn = "1933-6950",
publisher = "Landes Bioscience",
number = "5",
}