The role of mitochondrial DNA in the development of type 2 diabetes caused by fetal malnutrition

Yun Yong Lee, Kyong Soo Park, Youngmi Kim Pak, Hong Kyu Lee

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations

Abstract

Epidemiological studies have revealed strong and reproducible links between indices of poor fetal growth and susceptibility to the development of glucose intolerance and insulin resistance syndrome in adult life. To explain these associations, the thrifty phenotype hypothesis has been proposed. Mitochondrial DNA abnormalities have been known to cause insulin deficiency, insulin resistance and diabetes mellitus. In this review, we propose that mitochondrial dysfunction is a link between malnutrition during early life and disease in adult life. The potential mechanism for mitochondrial dysfunction will be focused on availability of the taurine and nucleotides, and imprinting on the genes.

Original languageEnglish
Pages (from-to)195-204
Number of pages10
JournalJournal of Nutritional Biochemistry
Volume16
Issue number4
DOIs
StatePublished - Apr 2005

Keywords

  • Fetal malnutrition
  • Mitochondrial DNA
  • Thrifty phenotype
  • Type 2 diabetes

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