The protective effects of Schisandra chinensis fruit extract and its lignans against cardiovascular disease: A review of the molecular mechanisms

Jung Nyeo Chun, Minsoo Cho, Insuk So, Ju Hong Jeon

Research output: Contribution to journalReview article

54 Citations (Scopus)

Abstract

Schisandra chinensis fruit extract (SCE) has traditionally been used as an oriental medicine for the treatment of various human diseases, including cardiovascular disease. Advances in scientific knowledge and analytical technologies provide opportunities for translational research involving S. chinensis; such research may contribute to future drug discovery. To date, emerging experimental evidence supports the therapeutic effects of the SCE or its bioactive lignan ingredients in cardiovascular disease, unraveling the mechanistic basis for their pharmacological actions. In the present review, we highlight SCE and its lignans as promising resources for the development of safe, effective, and multi-targeted agents against cardiovascular disease. Moreover, we offer novel insight into future challenges and perspective on S. chinensis research to future clinical investigations and healthcare strategies.

Original languageEnglish
Pages (from-to)224-233
Number of pages10
JournalFitoterapia
Volume97
DOIs
StatePublished - Sep 2014

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Schisandra
Lignans
Fruit
Cardiovascular Diseases
East Asian Traditional Medicine
Translational Medical Research
Therapeutic Uses
Drug Discovery
Research
Pharmacology
Technology
Delivery of Health Care

Keywords

  • Cardiovascular disease
  • Lignans
  • Molecular mechanism
  • Schisandra chinensis
  • Signaling pathway

Cite this

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The protective effects of Schisandra chinensis fruit extract and its lignans against cardiovascular disease : A review of the molecular mechanisms. / Chun, Jung Nyeo; Cho, Minsoo; So, Insuk; Jeon, Ju Hong.

In: Fitoterapia, Vol. 97, 09.2014, p. 224-233.

Research output: Contribution to journalReview article

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