The prevalence of cerebral microbleeds in non-demented Parkinson's disease patients

Kyeong Joon Kim, Youn Jung Bae, Jong-Min Kim, Beom Joon Kim, Eung Seok Oh, Ji Young Yun, Ji Seon Kim, Han-Joon Kim

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Abstract

Background: Cerebral microbleeds (CMBs) are associated with cerebrovascular risk factors and cognitive dysfunction among patients with Parkinson's disease (PD). However, whether CMBs themselves are associated with PD is to be elucidated. Methods: We analyzed the presence of CMBs using 3-Tesla brain magnetic resonance imaging in non-demented patients with PD and in age-, sex-, and hypertension-matched control subjects. PD patients were classified according to their motor subtypes: tremor-dominant, intermediate, and postural instability-gait disturbance (PIGD). Other cerebrovascular risk factors and small vessel disease (SVD) burdens were also evaluated. Results: Two-hundred and five patients with PD and 205 control subjects were included. The prevalence of CMBs was higher in PD patients than in controls (16.1% vs. 8.8%; odds ratio [OR], 2.126; P = 0.019); CMBs in the lobar area showed a significant difference between PD patients and controls (11.7% vs. 5.9%; OR, 2.234; P = 0.032). According to the motor subtype, CMBs in those with PIGD type showed significant difference from controls with respect to the overall brain area (21.1% vs. 8.9%; OR, 2.759; P = 0.010) and lobar area (14.6% vs. 4.9%; OR, 3.336; P = 0.016). Among PD patients, those with CMBs had higher age and more evidence of SVDs than those without CMBs. Conclusion: We found that CMBs are more frequent in PD patients than in controls, especially in those with the PIGD subtype and CMBs on the lobar area. Further study investigating the pathogenetic significance of CMBs is required.

Original languageEnglish
Article numbere289
JournalJournal of Korean Medical Science
Volume33
Issue number46
DOIs
StatePublished - 1 Nov 2018

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Parkinson Disease
Odds Ratio
Gait
Brain
Tremor
Magnetic Resonance Imaging
Hypertension

Keywords

  • Amyloid Angiopathy
  • Cerebral Microbleeds
  • Parkinson's Disease
  • Synucleinopathy

Cite this

@article{df0a33dae1d64d4cbe9f42928584872d,
title = "The prevalence of cerebral microbleeds in non-demented Parkinson's disease patients",
abstract = "Background: Cerebral microbleeds (CMBs) are associated with cerebrovascular risk factors and cognitive dysfunction among patients with Parkinson's disease (PD). However, whether CMBs themselves are associated with PD is to be elucidated. Methods: We analyzed the presence of CMBs using 3-Tesla brain magnetic resonance imaging in non-demented patients with PD and in age-, sex-, and hypertension-matched control subjects. PD patients were classified according to their motor subtypes: tremor-dominant, intermediate, and postural instability-gait disturbance (PIGD). Other cerebrovascular risk factors and small vessel disease (SVD) burdens were also evaluated. Results: Two-hundred and five patients with PD and 205 control subjects were included. The prevalence of CMBs was higher in PD patients than in controls (16.1{\%} vs. 8.8{\%}; odds ratio [OR], 2.126; P = 0.019); CMBs in the lobar area showed a significant difference between PD patients and controls (11.7{\%} vs. 5.9{\%}; OR, 2.234; P = 0.032). According to the motor subtype, CMBs in those with PIGD type showed significant difference from controls with respect to the overall brain area (21.1{\%} vs. 8.9{\%}; OR, 2.759; P = 0.010) and lobar area (14.6{\%} vs. 4.9{\%}; OR, 3.336; P = 0.016). Among PD patients, those with CMBs had higher age and more evidence of SVDs than those without CMBs. Conclusion: We found that CMBs are more frequent in PD patients than in controls, especially in those with the PIGD subtype and CMBs on the lobar area. Further study investigating the pathogenetic significance of CMBs is required.",
keywords = "Amyloid Angiopathy, Cerebral Microbleeds, Parkinson's Disease, Synucleinopathy",
author = "Kim, {Kyeong Joon} and Bae, {Youn Jung} and Jong-Min Kim and Kim, {Beom Joon} and Oh, {Eung Seok} and Yun, {Ji Young} and Kim, {Ji Seon} and Han-Joon Kim",
year = "2018",
month = "11",
day = "1",
doi = "10.3346/jkms.2018.33.e289",
language = "English",
volume = "33",
journal = "Journal of Korean medical science",
issn = "1011-8934",
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The prevalence of cerebral microbleeds in non-demented Parkinson's disease patients. / Kim, Kyeong Joon; Bae, Youn Jung; Kim, Jong-Min; Kim, Beom Joon; Oh, Eung Seok; Yun, Ji Young; Kim, Ji Seon; Kim, Han-Joon.

In: Journal of Korean Medical Science, Vol. 33, No. 46, e289, 01.11.2018.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - The prevalence of cerebral microbleeds in non-demented Parkinson's disease patients

AU - Kim, Kyeong Joon

AU - Bae, Youn Jung

AU - Kim, Jong-Min

AU - Kim, Beom Joon

AU - Oh, Eung Seok

AU - Yun, Ji Young

AU - Kim, Ji Seon

AU - Kim, Han-Joon

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Background: Cerebral microbleeds (CMBs) are associated with cerebrovascular risk factors and cognitive dysfunction among patients with Parkinson's disease (PD). However, whether CMBs themselves are associated with PD is to be elucidated. Methods: We analyzed the presence of CMBs using 3-Tesla brain magnetic resonance imaging in non-demented patients with PD and in age-, sex-, and hypertension-matched control subjects. PD patients were classified according to their motor subtypes: tremor-dominant, intermediate, and postural instability-gait disturbance (PIGD). Other cerebrovascular risk factors and small vessel disease (SVD) burdens were also evaluated. Results: Two-hundred and five patients with PD and 205 control subjects were included. The prevalence of CMBs was higher in PD patients than in controls (16.1% vs. 8.8%; odds ratio [OR], 2.126; P = 0.019); CMBs in the lobar area showed a significant difference between PD patients and controls (11.7% vs. 5.9%; OR, 2.234; P = 0.032). According to the motor subtype, CMBs in those with PIGD type showed significant difference from controls with respect to the overall brain area (21.1% vs. 8.9%; OR, 2.759; P = 0.010) and lobar area (14.6% vs. 4.9%; OR, 3.336; P = 0.016). Among PD patients, those with CMBs had higher age and more evidence of SVDs than those without CMBs. Conclusion: We found that CMBs are more frequent in PD patients than in controls, especially in those with the PIGD subtype and CMBs on the lobar area. Further study investigating the pathogenetic significance of CMBs is required.

AB - Background: Cerebral microbleeds (CMBs) are associated with cerebrovascular risk factors and cognitive dysfunction among patients with Parkinson's disease (PD). However, whether CMBs themselves are associated with PD is to be elucidated. Methods: We analyzed the presence of CMBs using 3-Tesla brain magnetic resonance imaging in non-demented patients with PD and in age-, sex-, and hypertension-matched control subjects. PD patients were classified according to their motor subtypes: tremor-dominant, intermediate, and postural instability-gait disturbance (PIGD). Other cerebrovascular risk factors and small vessel disease (SVD) burdens were also evaluated. Results: Two-hundred and five patients with PD and 205 control subjects were included. The prevalence of CMBs was higher in PD patients than in controls (16.1% vs. 8.8%; odds ratio [OR], 2.126; P = 0.019); CMBs in the lobar area showed a significant difference between PD patients and controls (11.7% vs. 5.9%; OR, 2.234; P = 0.032). According to the motor subtype, CMBs in those with PIGD type showed significant difference from controls with respect to the overall brain area (21.1% vs. 8.9%; OR, 2.759; P = 0.010) and lobar area (14.6% vs. 4.9%; OR, 3.336; P = 0.016). Among PD patients, those with CMBs had higher age and more evidence of SVDs than those without CMBs. Conclusion: We found that CMBs are more frequent in PD patients than in controls, especially in those with the PIGD subtype and CMBs on the lobar area. Further study investigating the pathogenetic significance of CMBs is required.

KW - Amyloid Angiopathy

KW - Cerebral Microbleeds

KW - Parkinson's Disease

KW - Synucleinopathy

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