The present and future of fractional flow reserve

Research output: Contribution to journalReview article

22 Citations (Scopus)

Abstract

Revascularization of coronary artery stenosis should be based on objective evidence of ischemia. Fractional flow reserve (FFR) is an invasive physiologic index that can be easily measured in the cardiac catheterization laboratory to assess the functional significance of coronary stenosis. FFR-guided revascularization strategy has been proven to be better than angiography-guided strategy in patients with coronary artery disease. Recent development of more convenient ways to induce hyperemia will reduce the barrier to measuring FFR and further expand its clinical applicability. Invasive physiologic indices without hyperemia are also under active investigation. Moreover, a novel noninvasive FFR measurement based on coronary CT angiography and computational fluid dynamics has been developed and will soon be incorporated into clinical practice. Given the rapid adoption of invasive and noninvasive physiologic indices in daily practice, a review of the current status of FFR and future perspectives is presented.

Original languageEnglish
Pages (from-to)1048-1054
Number of pages7
JournalCirculation Journal
Volume78
Issue number5
DOIs
StatePublished - 1 Jan 2014

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Coronary Stenosis
Hyperemia
Hydrodynamics
Cardiac Catheterization
Coronary Angiography
Coronary Artery Disease
Angiography
Ischemia
Computed Tomography Angiography

Keywords

  • Computational fluid dynamics
  • Coronary artery disease
  • Coronary computed tomographic angiography
  • Fractional flow reserve
  • Ischemia

Cite this

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abstract = "Revascularization of coronary artery stenosis should be based on objective evidence of ischemia. Fractional flow reserve (FFR) is an invasive physiologic index that can be easily measured in the cardiac catheterization laboratory to assess the functional significance of coronary stenosis. FFR-guided revascularization strategy has been proven to be better than angiography-guided strategy in patients with coronary artery disease. Recent development of more convenient ways to induce hyperemia will reduce the barrier to measuring FFR and further expand its clinical applicability. Invasive physiologic indices without hyperemia are also under active investigation. Moreover, a novel noninvasive FFR measurement based on coronary CT angiography and computational fluid dynamics has been developed and will soon be incorporated into clinical practice. Given the rapid adoption of invasive and noninvasive physiologic indices in daily practice, a review of the current status of FFR and future perspectives is presented.",
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The present and future of fractional flow reserve. / Koo, Bonkwon.

In: Circulation Journal, Vol. 78, No. 5, 01.01.2014, p. 1048-1054.

Research output: Contribution to journalReview article

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