Abstract

Background: Focal ground-glass opacity (GGO) is becoming a major concern because of its possible association with lung cancer. In this study, we analyzed the long-term progression of GGOs that persisted for more than 2 years. Methods: We reviewed focal GGOs identified by thin-section computed tomography that persisted for more than 2 years. Results: We enrolled a total of 114 patients with 175 GGO lesions. The median patient age was 61 years (range, 37-92 years) and 42 (36.8%) patients were male. Mean initial GGO size was 7.8 ± 4.4 mm. Median follow-up duration was 45 months. Forty-six (26.3%) GGOs had significant size increases (≥2 mm in the longest diameter) with a mean volume doubling time of 1041 days. In a multivariate analysis, large size (≥10 mm), the presence of a solid portion (mixed GGO) and old age (≥65 years) were risk factors for significant size increase, with odds ratios (95% CI) of 6.46 (2.69-15.6), 2.69 (1.11-6.95) and 2.55 (1.13-5.77), respectively. GGOs with character changes from pure to mixed or mixed to solid showed more rapid volume expansion. Conclusions: GGOs which persisted for several years showed an indolent course. Large lesions with a solid portion and GGOs in male or elderly individuals may be cause for more concern, as these factors were associated with size increase. Resection should be considered if GGOs show character changes, as these may be associated with rapid size progression.

Original languageEnglish
Pages (from-to)904-910
Number of pages7
JournalRespiratory Medicine
Volume107
Issue number6
DOIs
StatePublished - 1 Jun 2013

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Glass
Tomography
Lung Neoplasms
Multivariate Analysis
Odds Ratio

Keywords

  • Adenocarcinoma
  • Follow-up
  • Ground-glass opacity (GGO)
  • Lung cancer

Cite this

@article{a679a20a7c67446388813bf4bf28e640,
title = "The long-term course of ground-glass opacities detected on thin-section computed tomography",
abstract = "Background: Focal ground-glass opacity (GGO) is becoming a major concern because of its possible association with lung cancer. In this study, we analyzed the long-term progression of GGOs that persisted for more than 2 years. Methods: We reviewed focal GGOs identified by thin-section computed tomography that persisted for more than 2 years. Results: We enrolled a total of 114 patients with 175 GGO lesions. The median patient age was 61 years (range, 37-92 years) and 42 (36.8{\%}) patients were male. Mean initial GGO size was 7.8 ± 4.4 mm. Median follow-up duration was 45 months. Forty-six (26.3{\%}) GGOs had significant size increases (≥2 mm in the longest diameter) with a mean volume doubling time of 1041 days. In a multivariate analysis, large size (≥10 mm), the presence of a solid portion (mixed GGO) and old age (≥65 years) were risk factors for significant size increase, with odds ratios (95{\%} CI) of 6.46 (2.69-15.6), 2.69 (1.11-6.95) and 2.55 (1.13-5.77), respectively. GGOs with character changes from pure to mixed or mixed to solid showed more rapid volume expansion. Conclusions: GGOs which persisted for several years showed an indolent course. Large lesions with a solid portion and GGOs in male or elderly individuals may be cause for more concern, as these factors were associated with size increase. Resection should be considered if GGOs show character changes, as these may be associated with rapid size progression.",
keywords = "Adenocarcinoma, Follow-up, Ground-glass opacity (GGO), Lung cancer",
author = "Lee, {Sei Won} and Leem, {Cho Sun} and Kim, {Tae Jung} and Lee, {Kyung Won} and Chung, {Jin Haeng} and Sanghoon Jheon and Lee, {Jae Ho} and Lee, {Choon Taek}",
year = "2013",
month = "6",
day = "1",
doi = "10.1016/j.rmed.2013.02.014",
language = "English",
volume = "107",
pages = "904--910",
journal = "Respiratory Medicine",
issn = "0954-6111",
publisher = "W.B. Saunders Ltd",
number = "6",

}

The long-term course of ground-glass opacities detected on thin-section computed tomography. / Lee, Sei Won; Leem, Cho Sun; Kim, Tae Jung; Lee, Kyung Won; Chung, Jin Haeng; Jheon, Sanghoon; Lee, Jae Ho; Lee, Choon Taek.

In: Respiratory Medicine, Vol. 107, No. 6, 01.06.2013, p. 904-910.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The long-term course of ground-glass opacities detected on thin-section computed tomography

AU - Lee, Sei Won

AU - Leem, Cho Sun

AU - Kim, Tae Jung

AU - Lee, Kyung Won

AU - Chung, Jin Haeng

AU - Jheon, Sanghoon

AU - Lee, Jae Ho

AU - Lee, Choon Taek

PY - 2013/6/1

Y1 - 2013/6/1

N2 - Background: Focal ground-glass opacity (GGO) is becoming a major concern because of its possible association with lung cancer. In this study, we analyzed the long-term progression of GGOs that persisted for more than 2 years. Methods: We reviewed focal GGOs identified by thin-section computed tomography that persisted for more than 2 years. Results: We enrolled a total of 114 patients with 175 GGO lesions. The median patient age was 61 years (range, 37-92 years) and 42 (36.8%) patients were male. Mean initial GGO size was 7.8 ± 4.4 mm. Median follow-up duration was 45 months. Forty-six (26.3%) GGOs had significant size increases (≥2 mm in the longest diameter) with a mean volume doubling time of 1041 days. In a multivariate analysis, large size (≥10 mm), the presence of a solid portion (mixed GGO) and old age (≥65 years) were risk factors for significant size increase, with odds ratios (95% CI) of 6.46 (2.69-15.6), 2.69 (1.11-6.95) and 2.55 (1.13-5.77), respectively. GGOs with character changes from pure to mixed or mixed to solid showed more rapid volume expansion. Conclusions: GGOs which persisted for several years showed an indolent course. Large lesions with a solid portion and GGOs in male or elderly individuals may be cause for more concern, as these factors were associated with size increase. Resection should be considered if GGOs show character changes, as these may be associated with rapid size progression.

AB - Background: Focal ground-glass opacity (GGO) is becoming a major concern because of its possible association with lung cancer. In this study, we analyzed the long-term progression of GGOs that persisted for more than 2 years. Methods: We reviewed focal GGOs identified by thin-section computed tomography that persisted for more than 2 years. Results: We enrolled a total of 114 patients with 175 GGO lesions. The median patient age was 61 years (range, 37-92 years) and 42 (36.8%) patients were male. Mean initial GGO size was 7.8 ± 4.4 mm. Median follow-up duration was 45 months. Forty-six (26.3%) GGOs had significant size increases (≥2 mm in the longest diameter) with a mean volume doubling time of 1041 days. In a multivariate analysis, large size (≥10 mm), the presence of a solid portion (mixed GGO) and old age (≥65 years) were risk factors for significant size increase, with odds ratios (95% CI) of 6.46 (2.69-15.6), 2.69 (1.11-6.95) and 2.55 (1.13-5.77), respectively. GGOs with character changes from pure to mixed or mixed to solid showed more rapid volume expansion. Conclusions: GGOs which persisted for several years showed an indolent course. Large lesions with a solid portion and GGOs in male or elderly individuals may be cause for more concern, as these factors were associated with size increase. Resection should be considered if GGOs show character changes, as these may be associated with rapid size progression.

KW - Adenocarcinoma

KW - Follow-up

KW - Ground-glass opacity (GGO)

KW - Lung cancer

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U2 - 10.1016/j.rmed.2013.02.014

DO - 10.1016/j.rmed.2013.02.014

M3 - Article

C2 - 23514949

AN - SCOPUS:84877580423

VL - 107

SP - 904

EP - 910

JO - Respiratory Medicine

JF - Respiratory Medicine

SN - 0954-6111

IS - 6

ER -