The influence of metabolic factors for nonalcoholic fatty liver disease in women

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background/Aims. Women after menopause have increased insulin resistance and visceral fat, which may increase the prevalence of nonalcoholic fatty liver disease (NAFLD). However, the pathogenesis of NAFLD in women has not been clearly defined. In this study, we aimed to determine the risk factors for NAFLD in women. Methods. A retrospective cohort study was conducted. Women who underwent abdominal ultrasonography and blood sampling for routine health check-ups were recruited. Results. Among 1,423 subjects, 695 women (48.9%) were in a menopausal state. The prevalence of NAFLD was higher in postmenopausal women than in premenopausal women (27.2% versus 14.4%, P<0.001). In premenopausal women, low HDL-cholesterol, central obesity, and homeostasis model assessment-estimated insulin resistance showed a significant association with the increased risk of NAFLD in multivariate analysis. In postmenopausal women, the presence of diabetes, triglyceridemia, and central obesity showed a significant association with the risk of NAFLD. The presence of menopause and hormone replacement therapy in postmenopausal women were not risk factors for NAFLD. Conclusions. Our findings showed different metabolic factors for NAFLD in pre- and postmenopausal women. However, the key issues are the same: central obesity and insulin resistance. These results reemphasize the importance of metabolic factors irrespective of menopausal status in the pathogenesis of NAFLD in women.

Original languageEnglish
Article number131528
JournalBioMed Research International
Volume2015
DOIs
StatePublished - 1 Jan 2015

Fingerprint

Liver
Abdominal Obesity
Insulin
Insulin Resistance
Menopause
Ultrasonography
Non-alcoholic Fatty Liver Disease
Medical problems
HDL Cholesterol
Estrogen Replacement Therapy
Intra-Abdominal Fat
Blood
Fats
Health
Hormones
Sampling
Homeostasis
Cohort Studies
Multivariate Analysis
Retrospective Studies

Cite this

@article{3c204e6aa379462f9e19c96bf37207c7,
title = "The influence of metabolic factors for nonalcoholic fatty liver disease in women",
abstract = "Background/Aims. Women after menopause have increased insulin resistance and visceral fat, which may increase the prevalence of nonalcoholic fatty liver disease (NAFLD). However, the pathogenesis of NAFLD in women has not been clearly defined. In this study, we aimed to determine the risk factors for NAFLD in women. Methods. A retrospective cohort study was conducted. Women who underwent abdominal ultrasonography and blood sampling for routine health check-ups were recruited. Results. Among 1,423 subjects, 695 women (48.9{\%}) were in a menopausal state. The prevalence of NAFLD was higher in postmenopausal women than in premenopausal women (27.2{\%} versus 14.4{\%}, P<0.001). In premenopausal women, low HDL-cholesterol, central obesity, and homeostasis model assessment-estimated insulin resistance showed a significant association with the increased risk of NAFLD in multivariate analysis. In postmenopausal women, the presence of diabetes, triglyceridemia, and central obesity showed a significant association with the risk of NAFLD. The presence of menopause and hormone replacement therapy in postmenopausal women were not risk factors for NAFLD. Conclusions. Our findings showed different metabolic factors for NAFLD in pre- and postmenopausal women. However, the key issues are the same: central obesity and insulin resistance. These results reemphasize the importance of metabolic factors irrespective of menopausal status in the pathogenesis of NAFLD in women.",
author = "Chung, {Goh Eun} and Yim, {Jeong Yoon} and Donghee Kim and Lim, {Seon Hee} and Yang, {Jong In} and Kim, {Young Sun} and Yang, {Sun Young} and Kwak, {Min Sun} and Kim, {Joo Sung} and Cho, {Sang Heon}",
year = "2015",
month = "1",
day = "1",
doi = "10.1155/2015/131528",
language = "English",
volume = "2015",
journal = "BioMed research international",
issn = "2314-6133",
publisher = "Hindawi Publishing Corporation",

}

TY - JOUR

T1 - The influence of metabolic factors for nonalcoholic fatty liver disease in women

AU - Chung, Goh Eun

AU - Yim, Jeong Yoon

AU - Kim, Donghee

AU - Lim, Seon Hee

AU - Yang, Jong In

AU - Kim, Young Sun

AU - Yang, Sun Young

AU - Kwak, Min Sun

AU - Kim, Joo Sung

AU - Cho, Sang Heon

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Background/Aims. Women after menopause have increased insulin resistance and visceral fat, which may increase the prevalence of nonalcoholic fatty liver disease (NAFLD). However, the pathogenesis of NAFLD in women has not been clearly defined. In this study, we aimed to determine the risk factors for NAFLD in women. Methods. A retrospective cohort study was conducted. Women who underwent abdominal ultrasonography and blood sampling for routine health check-ups were recruited. Results. Among 1,423 subjects, 695 women (48.9%) were in a menopausal state. The prevalence of NAFLD was higher in postmenopausal women than in premenopausal women (27.2% versus 14.4%, P<0.001). In premenopausal women, low HDL-cholesterol, central obesity, and homeostasis model assessment-estimated insulin resistance showed a significant association with the increased risk of NAFLD in multivariate analysis. In postmenopausal women, the presence of diabetes, triglyceridemia, and central obesity showed a significant association with the risk of NAFLD. The presence of menopause and hormone replacement therapy in postmenopausal women were not risk factors for NAFLD. Conclusions. Our findings showed different metabolic factors for NAFLD in pre- and postmenopausal women. However, the key issues are the same: central obesity and insulin resistance. These results reemphasize the importance of metabolic factors irrespective of menopausal status in the pathogenesis of NAFLD in women.

AB - Background/Aims. Women after menopause have increased insulin resistance and visceral fat, which may increase the prevalence of nonalcoholic fatty liver disease (NAFLD). However, the pathogenesis of NAFLD in women has not been clearly defined. In this study, we aimed to determine the risk factors for NAFLD in women. Methods. A retrospective cohort study was conducted. Women who underwent abdominal ultrasonography and blood sampling for routine health check-ups were recruited. Results. Among 1,423 subjects, 695 women (48.9%) were in a menopausal state. The prevalence of NAFLD was higher in postmenopausal women than in premenopausal women (27.2% versus 14.4%, P<0.001). In premenopausal women, low HDL-cholesterol, central obesity, and homeostasis model assessment-estimated insulin resistance showed a significant association with the increased risk of NAFLD in multivariate analysis. In postmenopausal women, the presence of diabetes, triglyceridemia, and central obesity showed a significant association with the risk of NAFLD. The presence of menopause and hormone replacement therapy in postmenopausal women were not risk factors for NAFLD. Conclusions. Our findings showed different metabolic factors for NAFLD in pre- and postmenopausal women. However, the key issues are the same: central obesity and insulin resistance. These results reemphasize the importance of metabolic factors irrespective of menopausal status in the pathogenesis of NAFLD in women.

UR - http://www.scopus.com/inward/record.url?scp=84929379937&partnerID=8YFLogxK

U2 - 10.1155/2015/131528

DO - 10.1155/2015/131528

M3 - Article

C2 - 25973422

AN - SCOPUS:84929379937

VL - 2015

JO - BioMed research international

JF - BioMed research international

SN - 2314-6133

M1 - 131528

ER -