The increase of interfollicular epidermal stem cells and regulation of aryl hydrocarbon receptor and its repressors in the skin through hydroporation with anti-aging cocktail

Jung Won Shin, Hye Ryung Choi, Seung Hye Yang, Ji Young Choi, Jung Im Na, Chang Hun Hur, Kyungchan Park

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Backgrounds: Hydroporation is a procedure that involves a subsonic flow of air and microdroplets into the skin. We previously reported that hydroporation treatment with a cocktail solution containing copper-glycyl-L-histidyl-L-lysyl, oligo hyaluronic acid, rhodiola extract, tranexamic acid, and β-glucan yielded positive effects on skin aging. Objectives: The aim of this study was to evaluate the effects of hydroporation with anti-aging cocktail on interfollicular epidermal stem cells (IFESCs) and expression of aryl hydrocarbon receptor (AhR)/AhR repressor (AhRR) in the skin. Methods: Skin samples from six volunteers who were treated with hydroporation were analyzed via confocal microscopic examination. Results: Markers for dermal matrix (procollagen type I and fibrillin-1) and basement membrane (type IV collagen and integrin α6) were increased after treatment. Moreover, there was a significant increase in the expression level of histone deacetylase 1-positive/p63-negative basal cells, which we previously reported as interfollicular epidermal stem cells. The expression level of AhR was significantly decreased, whereas that of AhRR was increased. This indicates an alteration in the interaction between the skin and environment posttreatment. Conclusion: Anti-aging hydroporation treatment recovered the stem cell potential of basal cells. Moreover, this treatment decreased AhR and increased AhRR in the skin, which may protect the skin from the harmful environment.

Original languageEnglish
Pages (from-to)1133-1139
Number of pages7
JournalJournal of Cosmetic Dermatology
Volume18
Issue number4
DOIs
StatePublished - 1 Aug 2019

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Aryl Hydrocarbon Receptors
Stem Cells
Skin
Rhodiola
Histone Deacetylase 1
Tranexamic Acid
Skin Aging
Collagen Type IV
Glucans
Hyaluronic Acid
Therapeutics
Collagen Type I
Integrins
Copper
Volunteers
Air

Keywords

  • aryl hydrocarbon receptor
  • aryl hydrocarbon receptor repressor
  • hydroporation
  • skin aging
  • stem cells

Cite this

@article{6ed18fe9c265486cb92d76de5a030a97,
title = "The increase of interfollicular epidermal stem cells and regulation of aryl hydrocarbon receptor and its repressors in the skin through hydroporation with anti-aging cocktail",
abstract = "Backgrounds: Hydroporation is a procedure that involves a subsonic flow of air and microdroplets into the skin. We previously reported that hydroporation treatment with a cocktail solution containing copper-glycyl-L-histidyl-L-lysyl, oligo hyaluronic acid, rhodiola extract, tranexamic acid, and β-glucan yielded positive effects on skin aging. Objectives: The aim of this study was to evaluate the effects of hydroporation with anti-aging cocktail on interfollicular epidermal stem cells (IFESCs) and expression of aryl hydrocarbon receptor (AhR)/AhR repressor (AhRR) in the skin. Methods: Skin samples from six volunteers who were treated with hydroporation were analyzed via confocal microscopic examination. Results: Markers for dermal matrix (procollagen type I and fibrillin-1) and basement membrane (type IV collagen and integrin α6) were increased after treatment. Moreover, there was a significant increase in the expression level of histone deacetylase 1-positive/p63-negative basal cells, which we previously reported as interfollicular epidermal stem cells. The expression level of AhR was significantly decreased, whereas that of AhRR was increased. This indicates an alteration in the interaction between the skin and environment posttreatment. Conclusion: Anti-aging hydroporation treatment recovered the stem cell potential of basal cells. Moreover, this treatment decreased AhR and increased AhRR in the skin, which may protect the skin from the harmful environment.",
keywords = "aryl hydrocarbon receptor, aryl hydrocarbon receptor repressor, hydroporation, skin aging, stem cells",
author = "Shin, {Jung Won} and Choi, {Hye Ryung} and Yang, {Seung Hye} and Choi, {Ji Young} and Na, {Jung Im} and Hur, {Chang Hun} and Kyungchan Park",
year = "2019",
month = "8",
day = "1",
doi = "10.1111/jocd.12798",
language = "English",
volume = "18",
pages = "1133--1139",
journal = "Journal of Cosmetic Dermatology",
issn = "1473-2130",
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}

The increase of interfollicular epidermal stem cells and regulation of aryl hydrocarbon receptor and its repressors in the skin through hydroporation with anti-aging cocktail. / Shin, Jung Won; Choi, Hye Ryung; Yang, Seung Hye; Choi, Ji Young; Na, Jung Im; Hur, Chang Hun; Park, Kyungchan.

In: Journal of Cosmetic Dermatology, Vol. 18, No. 4, 01.08.2019, p. 1133-1139.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - The increase of interfollicular epidermal stem cells and regulation of aryl hydrocarbon receptor and its repressors in the skin through hydroporation with anti-aging cocktail

AU - Shin, Jung Won

AU - Choi, Hye Ryung

AU - Yang, Seung Hye

AU - Choi, Ji Young

AU - Na, Jung Im

AU - Hur, Chang Hun

AU - Park, Kyungchan

PY - 2019/8/1

Y1 - 2019/8/1

N2 - Backgrounds: Hydroporation is a procedure that involves a subsonic flow of air and microdroplets into the skin. We previously reported that hydroporation treatment with a cocktail solution containing copper-glycyl-L-histidyl-L-lysyl, oligo hyaluronic acid, rhodiola extract, tranexamic acid, and β-glucan yielded positive effects on skin aging. Objectives: The aim of this study was to evaluate the effects of hydroporation with anti-aging cocktail on interfollicular epidermal stem cells (IFESCs) and expression of aryl hydrocarbon receptor (AhR)/AhR repressor (AhRR) in the skin. Methods: Skin samples from six volunteers who were treated with hydroporation were analyzed via confocal microscopic examination. Results: Markers for dermal matrix (procollagen type I and fibrillin-1) and basement membrane (type IV collagen and integrin α6) were increased after treatment. Moreover, there was a significant increase in the expression level of histone deacetylase 1-positive/p63-negative basal cells, which we previously reported as interfollicular epidermal stem cells. The expression level of AhR was significantly decreased, whereas that of AhRR was increased. This indicates an alteration in the interaction between the skin and environment posttreatment. Conclusion: Anti-aging hydroporation treatment recovered the stem cell potential of basal cells. Moreover, this treatment decreased AhR and increased AhRR in the skin, which may protect the skin from the harmful environment.

AB - Backgrounds: Hydroporation is a procedure that involves a subsonic flow of air and microdroplets into the skin. We previously reported that hydroporation treatment with a cocktail solution containing copper-glycyl-L-histidyl-L-lysyl, oligo hyaluronic acid, rhodiola extract, tranexamic acid, and β-glucan yielded positive effects on skin aging. Objectives: The aim of this study was to evaluate the effects of hydroporation with anti-aging cocktail on interfollicular epidermal stem cells (IFESCs) and expression of aryl hydrocarbon receptor (AhR)/AhR repressor (AhRR) in the skin. Methods: Skin samples from six volunteers who were treated with hydroporation were analyzed via confocal microscopic examination. Results: Markers for dermal matrix (procollagen type I and fibrillin-1) and basement membrane (type IV collagen and integrin α6) were increased after treatment. Moreover, there was a significant increase in the expression level of histone deacetylase 1-positive/p63-negative basal cells, which we previously reported as interfollicular epidermal stem cells. The expression level of AhR was significantly decreased, whereas that of AhRR was increased. This indicates an alteration in the interaction between the skin and environment posttreatment. Conclusion: Anti-aging hydroporation treatment recovered the stem cell potential of basal cells. Moreover, this treatment decreased AhR and increased AhRR in the skin, which may protect the skin from the harmful environment.

KW - aryl hydrocarbon receptor

KW - aryl hydrocarbon receptor repressor

KW - hydroporation

KW - skin aging

KW - stem cells

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U2 - 10.1111/jocd.12798

DO - 10.1111/jocd.12798

M3 - Article

VL - 18

SP - 1133

EP - 1139

JO - Journal of Cosmetic Dermatology

JF - Journal of Cosmetic Dermatology

SN - 1473-2130

IS - 4

ER -