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Abstract

Background and purpose: The pathogenesis of rapid eye movement (REM) sleep behavior disorder (RBD) is not clear despite its frequent association with Parkinson's disease (PD). We investigated whether the nigrostriatal dopaminergic system is involved in the development of idiopathic RBD. Methods: Fourteen patients with RBD, 14 patients with PD and 12 normal controls were included in the study. The diagnosis of RBD was confirmed on polysomnography. All the participants performed single-photon emission computed tomography imaging 3 h after injection of [123I]FP-CIT. During REM sleep of the RBD patients, each 30-s epoch was rated as 'tonic' when there was at least 50% of tonically maintained chin electromyography (EMG) activity in the epoch. Phasic EMG activities were calculated as the percentage of 3-s mini-epoch containing phasic EMG events (leg and chin, separately). Results: The RBD patients showed a trend of lower binding in the striatum than the normal controls (P = 0.07), and the significance was revealed in the putamen (P = 0.02). However, in 11 individual cases of the 14 RBD patients, the dopamine transporter (DAT) densities in the putamen still remained within the normal range. In the RBD patients, there was no correlation between EMG activities and DAT densities. Conclusions: Nigrostriatal dopaminergic degeneration could be a part of the pathogenesis of RBD, but not essential for the development of RBD. The lack of correlation between RBD severity and DAT densities suggests that another pathogenic process not related to nigrostriatal dopaminergic transmission may be implicated in RBD.

Original languageEnglish
Pages (from-to)487-492
Number of pages6
JournalEuropean Journal of Neurology
Volume17
Issue number3
DOIs
StatePublished - 1 Mar 2010

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REM Sleep Behavior Disorder
Electromyography
Dopamine Plasma Membrane Transport Proteins
Chin
Putamen
Polysomnography
REM Sleep
Single-Photon Emission-Computed Tomography

Keywords

  • Dopamine transporter
  • FP-CIT SPECT
  • REM sleep behavior disorder

Cite this

@article{26bacc16f0c7450eae1a06b6dceffb64,
title = "The implication of nigrostriatal dopaminergic degeneration in the pathogenesis of REM sleep behavior disorder",
abstract = "Background and purpose: The pathogenesis of rapid eye movement (REM) sleep behavior disorder (RBD) is not clear despite its frequent association with Parkinson's disease (PD). We investigated whether the nigrostriatal dopaminergic system is involved in the development of idiopathic RBD. Methods: Fourteen patients with RBD, 14 patients with PD and 12 normal controls were included in the study. The diagnosis of RBD was confirmed on polysomnography. All the participants performed single-photon emission computed tomography imaging 3 h after injection of [123I]FP-CIT. During REM sleep of the RBD patients, each 30-s epoch was rated as 'tonic' when there was at least 50{\%} of tonically maintained chin electromyography (EMG) activity in the epoch. Phasic EMG activities were calculated as the percentage of 3-s mini-epoch containing phasic EMG events (leg and chin, separately). Results: The RBD patients showed a trend of lower binding in the striatum than the normal controls (P = 0.07), and the significance was revealed in the putamen (P = 0.02). However, in 11 individual cases of the 14 RBD patients, the dopamine transporter (DAT) densities in the putamen still remained within the normal range. In the RBD patients, there was no correlation between EMG activities and DAT densities. Conclusions: Nigrostriatal dopaminergic degeneration could be a part of the pathogenesis of RBD, but not essential for the development of RBD. The lack of correlation between RBD severity and DAT densities suggests that another pathogenic process not related to nigrostriatal dopaminergic transmission may be implicated in RBD.",
keywords = "Dopamine transporter, FP-CIT SPECT, REM sleep behavior disorder",
author = "Kim, {Y. K.} and Yoon, {I. Y.} and Kim, {J. M.} and Jeong, {S. H.} and Kim, {K. W.} and Shin, {Y. K.} and Kim, {B. S.} and Kim, {S. E.}",
year = "2010",
month = "3",
day = "1",
doi = "10.1111/j.1468-1331.2009.02854.x",
language = "English",
volume = "17",
pages = "487--492",
journal = "European Journal of Neurology",
issn = "1351-5101",
publisher = "Wiley-Blackwell Publishing Ltd",
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}

The implication of nigrostriatal dopaminergic degeneration in the pathogenesis of REM sleep behavior disorder. / Kim, Y. K.; Yoon, I. Y.; Kim, J. M.; Jeong, S. H.; Kim, K. W.; Shin, Y. K.; Kim, B. S.; Kim, S. E.

In: European Journal of Neurology, Vol. 17, No. 3, 01.03.2010, p. 487-492.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The implication of nigrostriatal dopaminergic degeneration in the pathogenesis of REM sleep behavior disorder

AU - Kim, Y. K.

AU - Yoon, I. Y.

AU - Kim, J. M.

AU - Jeong, S. H.

AU - Kim, K. W.

AU - Shin, Y. K.

AU - Kim, B. S.

AU - Kim, S. E.

PY - 2010/3/1

Y1 - 2010/3/1

N2 - Background and purpose: The pathogenesis of rapid eye movement (REM) sleep behavior disorder (RBD) is not clear despite its frequent association with Parkinson's disease (PD). We investigated whether the nigrostriatal dopaminergic system is involved in the development of idiopathic RBD. Methods: Fourteen patients with RBD, 14 patients with PD and 12 normal controls were included in the study. The diagnosis of RBD was confirmed on polysomnography. All the participants performed single-photon emission computed tomography imaging 3 h after injection of [123I]FP-CIT. During REM sleep of the RBD patients, each 30-s epoch was rated as 'tonic' when there was at least 50% of tonically maintained chin electromyography (EMG) activity in the epoch. Phasic EMG activities were calculated as the percentage of 3-s mini-epoch containing phasic EMG events (leg and chin, separately). Results: The RBD patients showed a trend of lower binding in the striatum than the normal controls (P = 0.07), and the significance was revealed in the putamen (P = 0.02). However, in 11 individual cases of the 14 RBD patients, the dopamine transporter (DAT) densities in the putamen still remained within the normal range. In the RBD patients, there was no correlation between EMG activities and DAT densities. Conclusions: Nigrostriatal dopaminergic degeneration could be a part of the pathogenesis of RBD, but not essential for the development of RBD. The lack of correlation between RBD severity and DAT densities suggests that another pathogenic process not related to nigrostriatal dopaminergic transmission may be implicated in RBD.

AB - Background and purpose: The pathogenesis of rapid eye movement (REM) sleep behavior disorder (RBD) is not clear despite its frequent association with Parkinson's disease (PD). We investigated whether the nigrostriatal dopaminergic system is involved in the development of idiopathic RBD. Methods: Fourteen patients with RBD, 14 patients with PD and 12 normal controls were included in the study. The diagnosis of RBD was confirmed on polysomnography. All the participants performed single-photon emission computed tomography imaging 3 h after injection of [123I]FP-CIT. During REM sleep of the RBD patients, each 30-s epoch was rated as 'tonic' when there was at least 50% of tonically maintained chin electromyography (EMG) activity in the epoch. Phasic EMG activities were calculated as the percentage of 3-s mini-epoch containing phasic EMG events (leg and chin, separately). Results: The RBD patients showed a trend of lower binding in the striatum than the normal controls (P = 0.07), and the significance was revealed in the putamen (P = 0.02). However, in 11 individual cases of the 14 RBD patients, the dopamine transporter (DAT) densities in the putamen still remained within the normal range. In the RBD patients, there was no correlation between EMG activities and DAT densities. Conclusions: Nigrostriatal dopaminergic degeneration could be a part of the pathogenesis of RBD, but not essential for the development of RBD. The lack of correlation between RBD severity and DAT densities suggests that another pathogenic process not related to nigrostriatal dopaminergic transmission may be implicated in RBD.

KW - Dopamine transporter

KW - FP-CIT SPECT

KW - REM sleep behavior disorder

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U2 - 10.1111/j.1468-1331.2009.02854.x

DO - 10.1111/j.1468-1331.2009.02854.x

M3 - Article

C2 - 19968708

AN - SCOPUS:77649121099

VL - 17

SP - 487

EP - 492

JO - European Journal of Neurology

JF - European Journal of Neurology

SN - 1351-5101

IS - 3

ER -