The growth rate and the positive prediction of needle biopsy of clinically diagnosed Warthin’s tumor

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Purpose: This study reports the clinical course, including the growth rate, of Warthin’s tumor (WT) and evaluates the positive prediction of needle biopsy for WT. Methods: The medical records of 182 patients clinically diagnosed with WT were retrospectively reviewed. Tumor growth rates were measured in patients who underwent serial radiologic exams with minimum 6-month time intervals, and the positive prediction value (PPV) of needle biopsy was evaluated in comparison with surgical pathology in patients who underwent surgical excision of the tumors. Results: Serial radiologic exams were available for growth rate measurement in 31 tumors (size 0.7–9.1 cm) from 25 patients. Among these, 24 tumors increased in size, and 7 were stable. The median follow-up duration was 23.5 months [interquartile range (IQR) 14.8–51.9], and the tumor growth rate ranged from − 0.36 to 2.26 cm per year (median 0.26, IQR 0.07–0.44). Needle biopsy results were available for comparison with postoperative pathology specimens in 147 patients. The PPV was 97.7% for fine-needle aspiration biopsy and 100% for core-needle biopsy. There were no reports of inflammation, facial nerve paralysis, or admission event during the follow-up. Conclusions: WT glows slowly and can be predicted by needle biopsy. Therefore, parotid masses diagnosed as Warthin’s tumor can be treated or left untreated based on the patient's needs and clinical decision-making.

Original languageEnglish
Pages (from-to)2091-2096
Number of pages6
JournalEuropean Archives of Oto-Rhino-Laryngology
Volume276
Issue number7
DOIs
StatePublished - 1 Jul 2019

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Adenolymphoma
Needle Biopsy
Growth
Neoplasms
Large-Core Needle Biopsy
Surgical Pathology
Facial Paralysis
Facial Nerve
Fine Needle Biopsy
Medical Records
Pathology
Inflammation

Keywords

  • Conservative management
  • Core-needle biopsy
  • Fine-needle aspiration biopsy
  • Growth rate
  • Warthin’s tumor

Cite this

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title = "The growth rate and the positive prediction of needle biopsy of clinically diagnosed Warthin’s tumor",
abstract = "Purpose: This study reports the clinical course, including the growth rate, of Warthin’s tumor (WT) and evaluates the positive prediction of needle biopsy for WT. Methods: The medical records of 182 patients clinically diagnosed with WT were retrospectively reviewed. Tumor growth rates were measured in patients who underwent serial radiologic exams with minimum 6-month time intervals, and the positive prediction value (PPV) of needle biopsy was evaluated in comparison with surgical pathology in patients who underwent surgical excision of the tumors. Results: Serial radiologic exams were available for growth rate measurement in 31 tumors (size 0.7–9.1 cm) from 25 patients. Among these, 24 tumors increased in size, and 7 were stable. The median follow-up duration was 23.5 months [interquartile range (IQR) 14.8–51.9], and the tumor growth rate ranged from − 0.36 to 2.26 cm per year (median 0.26, IQR 0.07–0.44). Needle biopsy results were available for comparison with postoperative pathology specimens in 147 patients. The PPV was 97.7{\%} for fine-needle aspiration biopsy and 100{\%} for core-needle biopsy. There were no reports of inflammation, facial nerve paralysis, or admission event during the follow-up. Conclusions: WT glows slowly and can be predicted by needle biopsy. Therefore, parotid masses diagnosed as Warthin’s tumor can be treated or left untreated based on the patient's needs and clinical decision-making.",
keywords = "Conservative management, Core-needle biopsy, Fine-needle aspiration biopsy, Growth rate, Warthin’s tumor",
author = "Jungirl Seok and Jeong, {Woo Jin} and Soon-Hyun Ahn and Jung, {Young Ho}",
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The growth rate and the positive prediction of needle biopsy of clinically diagnosed Warthin’s tumor. / Seok, Jungirl; Jeong, Woo Jin; Ahn, Soon-Hyun; Jung, Young Ho.

In: European Archives of Oto-Rhino-Laryngology, Vol. 276, No. 7, 01.07.2019, p. 2091-2096.

Research output: Contribution to journalArticleResearchpeer-review

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