The establishment of the Household Air Pollution Consortium (HAPCO)

H. Dean Hosgood, Madelyn Klugman, Keitaro Matsuo, Alexandra J. White, Atsuko Sadakane, Xiao Ou Shu, Ruy Lopez-Ridaura, Aesun Shin, Ichiro Tsuji, Reza Malekzadeh, Nolwenn Noisel, Parveen Bhatti, Gong Yang, Eiko Saito, Shafiur Rahman, Wei Hu, Bryan Bassig, George Downward, Roel Vermeulen, Xiaonan XueThomas Rohan, Sarah K. Abe, Philippe Broët, Eric J. Grant, Trevor J.B. Dummer, Nat Rothman, Manami Inoue, Martin Lajous, Keun Young Yoo, Hidemi Ito, Dale P. Sandler, Habib Ashan, Wei Zheng, Paolo Boffetta, Qing Lan

Research output: Contribution to journalArticle

Abstract

Household air pollution (HAP) is of public health concern, with ~3 billion people worldwide (including > 15 million in the US) exposed. HAP from coal use is a human lung carcinogen, yet the epidemiological evidence on carcinogenicity of HAP from biomass use, primarily wood, is not conclusive. To robustly assess biomass's carcinogenic potential, prospective studies of individuals experiencing a variety of HAP exposures are needed. We have built a global consortium of 13 prospective cohorts (HAPCO: Household Air Pollution Consortium) that have site- and disease-specific mortality and solid fuel use data, for a combined sample size of 587,257 participants and 57,483 deaths. HAPCO provides a novel opportunity to assess the association of HAP with lung cancer death while controlling for important confounders such as tobacco and outdoor air pollution exposures. HAPCO is also uniquely positioned to determine the risks associated with cancers other than lung as well as nonmalignant respiratory and cardiometabolic outcomes, for which prospective epidemiologic research is limited. HAPCO will facilitate research to address public health concerns associated with HAP-attributed exposures by enabling investigators to evaluate sex-specific and smoking status-specific effects under various exposure scenarios.

Original languageEnglish
Article number422
JournalAtmosphere
Volume10
Issue number7
DOIs
StatePublished - 1 Jul 2019

Keywords

  • Biomass
  • Cancer
  • Cohort studies
  • Consortium
  • Environmental exposures
  • Pollution

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    Hosgood, H. D., Klugman, M., Matsuo, K., White, A. J., Sadakane, A., Shu, X. O., Lopez-Ridaura, R., Shin, A., Tsuji, I., Malekzadeh, R., Noisel, N., Bhatti, P., Yang, G., Saito, E., Rahman, S., Hu, W., Bassig, B., Downward, G., Vermeulen, R., ... Lan, Q. (2019). The establishment of the Household Air Pollution Consortium (HAPCO). Atmosphere, 10(7), [422]. https://doi.org/10.3390/atmos10070422