The Effect of Vitamin D Deficiency Correction on the Outcomes in Women After Carpal Tunnel Release

Myung Ho Lee, Hyun Sik Gong, Min Ho Lee, Kwan Jae Cho, Jihyeung Kim, Goo Hyun Baek

Research output: Contribution to journalArticle


Purpose: Studies suggest that vitamin D supplementation improves myelination and recovery after nerve injuries. The purpose of this study was to evaluate whether correction of vitamin D level leads to better surgical outcomes in women with both carpal tunnel syndrome (CTS) and vitamin D deficiency. Methods: We retrospectively reviewed 84 vitamin D–deficient women with CTS who underwent carpal tunnel release and then received daily vitamin D supplementation of 1,000 IU vitamin D for 6 months. We also reviewed 35 control patients who were vitamin D–nondeficient at baseline and thus did not receive the supplementation. At baseline and 6 months after surgery, we measured serum vitamin D levels, the Disabilities of the Arm, Shoulder, and Hand (DASH) score, motor conduction velocity, and grip and pinch strengths. We compared the outcomes of CTS related to vitamin D levels. We also correlated baseline and follow-up vitamin D levels with the assessed parameters. Results: At 6 months, 59 patients became vitamin D–nondeficient (≥ 20 ng/mL) and 25 were still vitamin D–deficient (< 20 ng/mL). Patients who became vitamin D–nondeficient had subtle but better DASH scores than patients who were still vitamin D–deficient or the control patients. Vitamin D levels at 6 months were found to have significant correlation with the DASH score at 6 months. Vitamin D levels at 6 months did not have significant correlation with motor conduction velocity or grip and pinch strengths. Conclusions: Women with CTS and vitamin D deficiency showed subtle but better DASH scores after surgery when vitamin D deficiency was corrected by supplementation. Type of study/level of evidence: Therapeutic IV.

Original languageEnglish
Pages (from-to)649-654
Number of pages6
JournalJournal of Hand Surgery
Issue number8
StatePublished - 1 Aug 2019


  • Carpal tunnel release
  • carpal tunnel syndrome
  • outcome
  • vitamin D deficiency

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