The effect of 2% methylhydroxypropylcellulose and hyaluronic acid on adjustable force in experimental adjustable strabismus surgery in rabbits

K. H. Lim, Y. J. Lee, Y. S. Yu, B. L. Chang

Research output: Contribution to journalArticle

Abstract

Purpose. To evaluate the effect of 2% methylhydroxypropylcellulose and hyaluronic acid on adjustable force in experimental adjustable strabismus surgery in rabbits. Methods. When we performed a 4 mm recession of the superior rectus muscle using adjustable suture technique, 11 eyes (Group 1) received 2% methylhydroxypropylcellulose & 11 eyes (Group 2) received hyaluronic acid around the superior rectus muscle, respectively. 10 eyes, used as controls, underwent the same procedure without viscoelastic materials. At 24 hours after operation, we measured the force required to move the superior rectus muscle, using tension gauge. Histologic examinations were done at 1 day, and 3 months after operation. Results. The average forces required to move the superior rectus muscle were 14.9 ± 3.6 g in group 1, 12.4 ± 4.2 g in group 2 and 22.5 ± 9.1 g in control group. The force in group 1 and group 2 was significantly lower than that of the control group, respectively. (p<0.05, Mann-Whitney U test) On light microsconic examination, there were no muscle necrosis and foreign body reaction in group 1 and group 2, respectively. Conclusions. 2% Methylhydroxypropylcellulose and hyaluronic acid was effective in reducing the adjustable force in experimental adjustable strabismus surgery in rabbits, respectively.

Original languageEnglish
JournalInvestigative Ophthalmology and Visual Science
Volume37
Issue number3
StatePublished - 15 Feb 1996

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