The clinicopathologic correlations of histologic tumor necrosis for the patients with renal cell carcinoma

In Ho Chang, Tae Beom Kim, Myung Cheol Gil, Yong Jun Kim, Sung Kyu Hong, Seok-Soo Byun, Gheeyoung Choe, Sang Eun Lee

Research output: Contribution to journalArticle

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Abstract

Purpose: The authors investigated the relation of histologic tumor necrosis to the other clinicopathologic factors that are known to be important prognostic indicators for the patients with renal cell carcinoma (RCC). Materials and Methods: The records of 89 patients who were surgically treated for RCC between June 2003 and July 2005 were evaluated for their basic clinical, laboratory and pathologic information, including the TNM classification, the nuclear grade and the Ki-67 expression. The association of the presence and extent of histologic tumor necrosis with the clinical, laboratory and pathologic features, and the Ki-67 labeling index were examined with chi-square tests, Fisher's exact test, Pearson's correlation analysis, Spearman correlation analysis and multivariate logistic regression analysis. Results: Histologic tumor necrosis was present in 34 of the 89 (38.2%) total RCCs, 24 of 73 (32.9%) conventional RCCs, 9 of 13 (69.2%) papillary RCCs and 1 of 3 (33.3%) chromophobe RCCs. The presence of histologic necrosis in the primary tumor of the patients with RCC compared to the patients with RCC without necrosis was associated with higher levels of anemia, hypercalcemia, hyperalkaline phosphatemia, a higher TNM stage and grade, more perirenal fat invasion, lymphovascular invasion, sarcomatoid change and renal vein thrombosis, a higher Ki-67 labeling index and a larger tumor size. When classifying the RCC according to the histologic subtype, for the conventional RCC, histologic tumor necrosis was associated with the same clinical, laboratory and pathologic features, and the same Ki-67 labelling index as that of the other types of RCCs. The extent of necrosis in the conventional RCC was associated with the TNM stage (r=0.44, p=0.033). Multivariate analysis demonstrated that a higher TNM stage (odd ratio: 5.667; p=0.036; 95% confidence interval: 2.125-63.120) was an independent predictor of histologic tumor necrosis for conventional RCC. Conclusions: The presence of histologic necrosis was a predictor of the outcome for conventional RCC, and it should be routinely reported and used in clinical assessment.

Original languageEnglish
Pages (from-to)449-455
Number of pages7
JournalKorean Journal of Urology
Volume47
Issue number5
DOIs
StatePublished - May 2006

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Renal Cell Carcinoma
Necrosis
Neoplasms
Multivariate Analysis
Renal Veins
Neoplasm Staging
Hypercalcemia
Chi-Square Distribution
Anemia
Thrombosis
Logistic Models
Fats
Odds Ratio
Regression Analysis
Confidence Intervals

Keywords

  • Necrosis
  • Renal cell carcinoma
  • Tumor

Cite this

Chang, In Ho ; Kim, Tae Beom ; Gil, Myung Cheol ; Kim, Yong Jun ; Hong, Sung Kyu ; Byun, Seok-Soo ; Choe, Gheeyoung ; Lee, Sang Eun. / The clinicopathologic correlations of histologic tumor necrosis for the patients with renal cell carcinoma. In: Korean Journal of Urology. 2006 ; Vol. 47, No. 5. pp. 449-455.
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title = "The clinicopathologic correlations of histologic tumor necrosis for the patients with renal cell carcinoma",
abstract = "Purpose: The authors investigated the relation of histologic tumor necrosis to the other clinicopathologic factors that are known to be important prognostic indicators for the patients with renal cell carcinoma (RCC). Materials and Methods: The records of 89 patients who were surgically treated for RCC between June 2003 and July 2005 were evaluated for their basic clinical, laboratory and pathologic information, including the TNM classification, the nuclear grade and the Ki-67 expression. The association of the presence and extent of histologic tumor necrosis with the clinical, laboratory and pathologic features, and the Ki-67 labeling index were examined with chi-square tests, Fisher's exact test, Pearson's correlation analysis, Spearman correlation analysis and multivariate logistic regression analysis. Results: Histologic tumor necrosis was present in 34 of the 89 (38.2{\%}) total RCCs, 24 of 73 (32.9{\%}) conventional RCCs, 9 of 13 (69.2{\%}) papillary RCCs and 1 of 3 (33.3{\%}) chromophobe RCCs. The presence of histologic necrosis in the primary tumor of the patients with RCC compared to the patients with RCC without necrosis was associated with higher levels of anemia, hypercalcemia, hyperalkaline phosphatemia, a higher TNM stage and grade, more perirenal fat invasion, lymphovascular invasion, sarcomatoid change and renal vein thrombosis, a higher Ki-67 labeling index and a larger tumor size. When classifying the RCC according to the histologic subtype, for the conventional RCC, histologic tumor necrosis was associated with the same clinical, laboratory and pathologic features, and the same Ki-67 labelling index as that of the other types of RCCs. The extent of necrosis in the conventional RCC was associated with the TNM stage (r=0.44, p=0.033). Multivariate analysis demonstrated that a higher TNM stage (odd ratio: 5.667; p=0.036; 95{\%} confidence interval: 2.125-63.120) was an independent predictor of histologic tumor necrosis for conventional RCC. Conclusions: The presence of histologic necrosis was a predictor of the outcome for conventional RCC, and it should be routinely reported and used in clinical assessment.",
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The clinicopathologic correlations of histologic tumor necrosis for the patients with renal cell carcinoma. / Chang, In Ho; Kim, Tae Beom; Gil, Myung Cheol; Kim, Yong Jun; Hong, Sung Kyu; Byun, Seok-Soo; Choe, Gheeyoung; Lee, Sang Eun.

In: Korean Journal of Urology, Vol. 47, No. 5, 05.2006, p. 449-455.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The clinicopathologic correlations of histologic tumor necrosis for the patients with renal cell carcinoma

AU - Chang, In Ho

AU - Kim, Tae Beom

AU - Gil, Myung Cheol

AU - Kim, Yong Jun

AU - Hong, Sung Kyu

AU - Byun, Seok-Soo

AU - Choe, Gheeyoung

AU - Lee, Sang Eun

PY - 2006/5

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N2 - Purpose: The authors investigated the relation of histologic tumor necrosis to the other clinicopathologic factors that are known to be important prognostic indicators for the patients with renal cell carcinoma (RCC). Materials and Methods: The records of 89 patients who were surgically treated for RCC between June 2003 and July 2005 were evaluated for their basic clinical, laboratory and pathologic information, including the TNM classification, the nuclear grade and the Ki-67 expression. The association of the presence and extent of histologic tumor necrosis with the clinical, laboratory and pathologic features, and the Ki-67 labeling index were examined with chi-square tests, Fisher's exact test, Pearson's correlation analysis, Spearman correlation analysis and multivariate logistic regression analysis. Results: Histologic tumor necrosis was present in 34 of the 89 (38.2%) total RCCs, 24 of 73 (32.9%) conventional RCCs, 9 of 13 (69.2%) papillary RCCs and 1 of 3 (33.3%) chromophobe RCCs. The presence of histologic necrosis in the primary tumor of the patients with RCC compared to the patients with RCC without necrosis was associated with higher levels of anemia, hypercalcemia, hyperalkaline phosphatemia, a higher TNM stage and grade, more perirenal fat invasion, lymphovascular invasion, sarcomatoid change and renal vein thrombosis, a higher Ki-67 labeling index and a larger tumor size. When classifying the RCC according to the histologic subtype, for the conventional RCC, histologic tumor necrosis was associated with the same clinical, laboratory and pathologic features, and the same Ki-67 labelling index as that of the other types of RCCs. The extent of necrosis in the conventional RCC was associated with the TNM stage (r=0.44, p=0.033). Multivariate analysis demonstrated that a higher TNM stage (odd ratio: 5.667; p=0.036; 95% confidence interval: 2.125-63.120) was an independent predictor of histologic tumor necrosis for conventional RCC. Conclusions: The presence of histologic necrosis was a predictor of the outcome for conventional RCC, and it should be routinely reported and used in clinical assessment.

AB - Purpose: The authors investigated the relation of histologic tumor necrosis to the other clinicopathologic factors that are known to be important prognostic indicators for the patients with renal cell carcinoma (RCC). Materials and Methods: The records of 89 patients who were surgically treated for RCC between June 2003 and July 2005 were evaluated for their basic clinical, laboratory and pathologic information, including the TNM classification, the nuclear grade and the Ki-67 expression. The association of the presence and extent of histologic tumor necrosis with the clinical, laboratory and pathologic features, and the Ki-67 labeling index were examined with chi-square tests, Fisher's exact test, Pearson's correlation analysis, Spearman correlation analysis and multivariate logistic regression analysis. Results: Histologic tumor necrosis was present in 34 of the 89 (38.2%) total RCCs, 24 of 73 (32.9%) conventional RCCs, 9 of 13 (69.2%) papillary RCCs and 1 of 3 (33.3%) chromophobe RCCs. The presence of histologic necrosis in the primary tumor of the patients with RCC compared to the patients with RCC without necrosis was associated with higher levels of anemia, hypercalcemia, hyperalkaline phosphatemia, a higher TNM stage and grade, more perirenal fat invasion, lymphovascular invasion, sarcomatoid change and renal vein thrombosis, a higher Ki-67 labeling index and a larger tumor size. When classifying the RCC according to the histologic subtype, for the conventional RCC, histologic tumor necrosis was associated with the same clinical, laboratory and pathologic features, and the same Ki-67 labelling index as that of the other types of RCCs. The extent of necrosis in the conventional RCC was associated with the TNM stage (r=0.44, p=0.033). Multivariate analysis demonstrated that a higher TNM stage (odd ratio: 5.667; p=0.036; 95% confidence interval: 2.125-63.120) was an independent predictor of histologic tumor necrosis for conventional RCC. Conclusions: The presence of histologic necrosis was a predictor of the outcome for conventional RCC, and it should be routinely reported and used in clinical assessment.

KW - Necrosis

KW - Renal cell carcinoma

KW - Tumor

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