The characteristics of prostate cancer with metabolic syndrome in Korean men

Byoung Kyu Han, Woo Suk Choi, Ji Hyung Yu, Jun Hyun Han, In Ho Chang, Seong Jin Jeong, Sung Kyu Hong, Seok-Soo Byun, Sang Eun Lee

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purpose: Metabolic syndrome, a concurrence of disturbed glucose and insulin metabolism, overweight, abdominal fat distribution, dyslipidemia, and hypertension, has been reported to have some association with prostate cancer. Here, we assessed the relationship between metabolic syndrome and prostate cancer. Materials and Methods: We assessed a total of 261 men who underwent radical retropubic prostatectomy between January 2004 and May 2005. The patients were stratified into two groups, with metabolic syndrome (n=75) or without (n=186). Metabolic syndrome was defined by the criteria of National Cholesterol Education Program Adult Treatment Panel III. We compared the clinical and pathologic features of specimens between the groups. Results: There was no significant difference between the two groups in terms of mean age, serum prostate specific antigen level, prostate size, Gleason score, and pathologic stage. The tumor volume of prostate cancer was significantly higher in the metabolic syndrome group (6.6 ± 5.5cc vs 5.0±4.5cc, p=0.010). No significant differences were observed in extracapsular extension, seminal vesicle invasion, bladder neck invasion, angiolymphatic invasion, perineural invasion, and multicentricity of cancer between the two groups. As the component of metabolic syndrome increased, the tumor volume was also found to increase (p-value=0.025). Conclusions: The data from our study support that metabolic syndrome is closely associated with the development and progression of prostate cancer.

Original languageEnglish
Pages (from-to)585-591
Number of pages7
JournalKorean Journal of Urology
Volume48
Issue number6
DOIs
StatePublished - Jun 2007

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Prostatic Neoplasms
Tumor Burden
Abdominal Fat
Neoplasm Grading
Seminal Vesicles
Prostate-Specific Antigen
Prostatectomy
Dyslipidemias
Prostate
Urinary Bladder
Cholesterol
Insulin
Hypertension
Education
Glucose
Serum
Neoplasms

Keywords

  • Metabolic syndrome X
  • Prostate neoplasm

Cite this

Han, B. K., Choi, W. S., Yu, J. H., Han, J. H., Chang, I. H., Jeong, S. J., ... Lee, S. E. (2007). The characteristics of prostate cancer with metabolic syndrome in Korean men. Korean Journal of Urology, 48(6), 585-591. https://doi.org/10.4111/kju.2007.48.6.585
Han, Byoung Kyu ; Choi, Woo Suk ; Yu, Ji Hyung ; Han, Jun Hyun ; Chang, In Ho ; Jeong, Seong Jin ; Hong, Sung Kyu ; Byun, Seok-Soo ; Lee, Sang Eun. / The characteristics of prostate cancer with metabolic syndrome in Korean men. In: Korean Journal of Urology. 2007 ; Vol. 48, No. 6. pp. 585-591.
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The characteristics of prostate cancer with metabolic syndrome in Korean men. / Han, Byoung Kyu; Choi, Woo Suk; Yu, Ji Hyung; Han, Jun Hyun; Chang, In Ho; Jeong, Seong Jin; Hong, Sung Kyu; Byun, Seok-Soo; Lee, Sang Eun.

In: Korean Journal of Urology, Vol. 48, No. 6, 06.2007, p. 585-591.

Research output: Contribution to journalArticle

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T1 - The characteristics of prostate cancer with metabolic syndrome in Korean men

AU - Han, Byoung Kyu

AU - Choi, Woo Suk

AU - Yu, Ji Hyung

AU - Han, Jun Hyun

AU - Chang, In Ho

AU - Jeong, Seong Jin

AU - Hong, Sung Kyu

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AB - Purpose: Metabolic syndrome, a concurrence of disturbed glucose and insulin metabolism, overweight, abdominal fat distribution, dyslipidemia, and hypertension, has been reported to have some association with prostate cancer. Here, we assessed the relationship between metabolic syndrome and prostate cancer. Materials and Methods: We assessed a total of 261 men who underwent radical retropubic prostatectomy between January 2004 and May 2005. The patients were stratified into two groups, with metabolic syndrome (n=75) or without (n=186). Metabolic syndrome was defined by the criteria of National Cholesterol Education Program Adult Treatment Panel III. We compared the clinical and pathologic features of specimens between the groups. Results: There was no significant difference between the two groups in terms of mean age, serum prostate specific antigen level, prostate size, Gleason score, and pathologic stage. The tumor volume of prostate cancer was significantly higher in the metabolic syndrome group (6.6 ± 5.5cc vs 5.0±4.5cc, p=0.010). No significant differences were observed in extracapsular extension, seminal vesicle invasion, bladder neck invasion, angiolymphatic invasion, perineural invasion, and multicentricity of cancer between the two groups. As the component of metabolic syndrome increased, the tumor volume was also found to increase (p-value=0.025). Conclusions: The data from our study support that metabolic syndrome is closely associated with the development and progression of prostate cancer.

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