The association of rate of weight gain during early adulthood with the prevalence of subclinical coronary artery disease in recently diagnosed type 2 diabetes: The MAXWEL-CAD study

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Abstract

Objective: To investigate the association of the rate of weight gain (Ratemax-wt) between the age of 20 years and the age of maximum lifetime weight gain with indicators of subclinical coronary artery disease (CAD) at the time of diagnosis of≥30 years with recently diagnosed (within 3 months) T2D and one or more cardiovascular risk factors to investigate the association of Ratemax-wt with subclinical CAD. We used 64-slice cardiac computed tomography angiography to evaluate the degree of coronary artery stenosis, multivessel involvement, plaque characteristics, and coronary artery calcium score (CACS). Body weight at age 20 years (Wt20y) was obtained from participant records. Participants recalled their maximum weight (Wtmax) before T2D diagnosis and age at maximum weight (Agemax-wt). The Ratemax-wt was calculated as (Wtmax-wt20y) / (Age max-wt- 20 years). Results: The prevalence of coronary artery stenosis (≤50%), multivessel involvement (two or more vessels), plaque characteristics, and CACS <100 were 11.4%, 6.6%, 19.7%, and 12.8%, respectively. MeanWt20y andWtmax were 60.1610.5 and 73.0611.5 kg, respectively. Mean Agemax-wt was 41.3 6 10.7 years, and Rate max-wt was 0.59 6 0.56 kg/year. After adjusting for cardiovascular risk factors, including current BMI, the highest quarter of prior weight gain was significantly associated with coronary artery stenosis, multivessel involvement, and plaque characteristics, particularly mixed and noncalcified plaque. CONCLUSIONS: The findings suggest that a greater rate of prior weight gain may accelerate the development of subclinical vascular complications in patients with newly diagnosed T2D.

Original languageEnglish
Pages (from-to)2491-2499
Number of pages9
JournalDiabetes Care
Volume37
Issue number9
DOIs
StatePublished - Sep 2014

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Type 2 Diabetes Mellitus
Weight Gain
Coronary Artery Disease
Coronary Stenosis
Weights and Measures
Coronary Vessels
Calcium
Blood Vessels
Body Weight

Cite this

@article{325bcb77253d420287ee3bf7df0aaa63,
title = "The association of rate of weight gain during early adulthood with the prevalence of subclinical coronary artery disease in recently diagnosed type 2 diabetes: The MAXWEL-CAD study",
abstract = "Objective: To investigate the association of the rate of weight gain (Ratemax-wt) between the age of 20 years and the age of maximum lifetime weight gain with indicators of subclinical coronary artery disease (CAD) at the time of diagnosis of≥30 years with recently diagnosed (within 3 months) T2D and one or more cardiovascular risk factors to investigate the association of Ratemax-wt with subclinical CAD. We used 64-slice cardiac computed tomography angiography to evaluate the degree of coronary artery stenosis, multivessel involvement, plaque characteristics, and coronary artery calcium score (CACS). Body weight at age 20 years (Wt20y) was obtained from participant records. Participants recalled their maximum weight (Wtmax) before T2D diagnosis and age at maximum weight (Agemax-wt). The Ratemax-wt was calculated as (Wtmax-wt20y) / (Age max-wt- 20 years). Results: The prevalence of coronary artery stenosis (≤50{\%}), multivessel involvement (two or more vessels), plaque characteristics, and CACS <100 were 11.4{\%}, 6.6{\%}, 19.7{\%}, and 12.8{\%}, respectively. MeanWt20y andWtmax were 60.1610.5 and 73.0611.5 kg, respectively. Mean Agemax-wt was 41.3 6 10.7 years, and Rate max-wt was 0.59 6 0.56 kg/year. After adjusting for cardiovascular risk factors, including current BMI, the highest quarter of prior weight gain was significantly associated with coronary artery stenosis, multivessel involvement, and plaque characteristics, particularly mixed and noncalcified plaque. CONCLUSIONS: The findings suggest that a greater rate of prior weight gain may accelerate the development of subclinical vascular complications in patients with newly diagnosed T2D.",
author = "Soo Lim and Choi, {Sung Hee} and Kim, {Kyung Min} and Sangil Choi and Chun, {Eun Ju} and Kim, {Min Joo} and Park, {Kyong Soo} and Jang, {Hak Chul} and Naveed Sattar",
year = "2014",
month = "9",
doi = "10.2337/dc13-2365",
language = "English",
volume = "37",
pages = "2491--2499",
journal = "Diabetes care",
issn = "0149-5992",
publisher = "American Diabetes Association Inc.",
number = "9",

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TY - JOUR

T1 - The association of rate of weight gain during early adulthood with the prevalence of subclinical coronary artery disease in recently diagnosed type 2 diabetes

T2 - The MAXWEL-CAD study

AU - Lim, Soo

AU - Choi, Sung Hee

AU - Kim, Kyung Min

AU - Choi, Sangil

AU - Chun, Eun Ju

AU - Kim, Min Joo

AU - Park, Kyong Soo

AU - Jang, Hak Chul

AU - Sattar, Naveed

PY - 2014/9

Y1 - 2014/9

N2 - Objective: To investigate the association of the rate of weight gain (Ratemax-wt) between the age of 20 years and the age of maximum lifetime weight gain with indicators of subclinical coronary artery disease (CAD) at the time of diagnosis of≥30 years with recently diagnosed (within 3 months) T2D and one or more cardiovascular risk factors to investigate the association of Ratemax-wt with subclinical CAD. We used 64-slice cardiac computed tomography angiography to evaluate the degree of coronary artery stenosis, multivessel involvement, plaque characteristics, and coronary artery calcium score (CACS). Body weight at age 20 years (Wt20y) was obtained from participant records. Participants recalled their maximum weight (Wtmax) before T2D diagnosis and age at maximum weight (Agemax-wt). The Ratemax-wt was calculated as (Wtmax-wt20y) / (Age max-wt- 20 years). Results: The prevalence of coronary artery stenosis (≤50%), multivessel involvement (two or more vessels), plaque characteristics, and CACS <100 were 11.4%, 6.6%, 19.7%, and 12.8%, respectively. MeanWt20y andWtmax were 60.1610.5 and 73.0611.5 kg, respectively. Mean Agemax-wt was 41.3 6 10.7 years, and Rate max-wt was 0.59 6 0.56 kg/year. After adjusting for cardiovascular risk factors, including current BMI, the highest quarter of prior weight gain was significantly associated with coronary artery stenosis, multivessel involvement, and plaque characteristics, particularly mixed and noncalcified plaque. CONCLUSIONS: The findings suggest that a greater rate of prior weight gain may accelerate the development of subclinical vascular complications in patients with newly diagnosed T2D.

AB - Objective: To investigate the association of the rate of weight gain (Ratemax-wt) between the age of 20 years and the age of maximum lifetime weight gain with indicators of subclinical coronary artery disease (CAD) at the time of diagnosis of≥30 years with recently diagnosed (within 3 months) T2D and one or more cardiovascular risk factors to investigate the association of Ratemax-wt with subclinical CAD. We used 64-slice cardiac computed tomography angiography to evaluate the degree of coronary artery stenosis, multivessel involvement, plaque characteristics, and coronary artery calcium score (CACS). Body weight at age 20 years (Wt20y) was obtained from participant records. Participants recalled their maximum weight (Wtmax) before T2D diagnosis and age at maximum weight (Agemax-wt). The Ratemax-wt was calculated as (Wtmax-wt20y) / (Age max-wt- 20 years). Results: The prevalence of coronary artery stenosis (≤50%), multivessel involvement (two or more vessels), plaque characteristics, and CACS <100 were 11.4%, 6.6%, 19.7%, and 12.8%, respectively. MeanWt20y andWtmax were 60.1610.5 and 73.0611.5 kg, respectively. Mean Agemax-wt was 41.3 6 10.7 years, and Rate max-wt was 0.59 6 0.56 kg/year. After adjusting for cardiovascular risk factors, including current BMI, the highest quarter of prior weight gain was significantly associated with coronary artery stenosis, multivessel involvement, and plaque characteristics, particularly mixed and noncalcified plaque. CONCLUSIONS: The findings suggest that a greater rate of prior weight gain may accelerate the development of subclinical vascular complications in patients with newly diagnosed T2D.

UR - http://www.scopus.com/inward/record.url?scp=84906707055&partnerID=8YFLogxK

U2 - 10.2337/dc13-2365

DO - 10.2337/dc13-2365

M3 - Article

C2 - 24914242

AN - SCOPUS:84906707055

VL - 37

SP - 2491

EP - 2499

JO - Diabetes care

JF - Diabetes care

SN - 0149-5992

IS - 9

ER -