The association between liver fat and systemic calcified atherosclerosis

Bo Kyung Koo, Matthew A. Allison, Michael H. Criqui, Julie O. Denenberg, C. Michael Wright

Research output: Contribution to journalArticle

Abstract

Background: The association of nonalcoholic fatty liver disease (NAFLD) with systemic calcified atherosclerosis, other than the coronary arteries, has not been clearly elucidated. We investigated the association between NAFLD and calcification in eight different vascular beds. Methods: In a community-based cohort with computed tomography scans for carotid artery, coronary artery, thoracic aorta, abdominal aorta, iliac artery, renal artery, celiac trunk, and superior mesenteric artery, the association between NAFLD and arterial calcification was evaluated with adjustment for age, sex, hypertension, dyslipidemia, diabetes, obesity, current smoking status, and family history of heart disease in the first-degree relatives. Results: In age- and sex-adjusted models, NAFLD was significantly associated with calcification in the coronary artery, carotid artery, thoracic aorta, celiac trunk, and superior mesenteric artery vascular beds (P <.05). However, adjustment for the traditional chronic venous disease risk factors attenuated the associations, except in the case of the thoracic aorta (odds ratio [OR], 1.38; 95% confidence interval [CI], 1.09-1.78) and celiac trunk (OR, 2.05; 95% CI, 1.16-3.65). In addition, NAFLD was independently associated with multiarterial calcification (four or more [OR, 1.33; 95% CI, 1.01-1.74], five or more [OR, 1.46; 95% CI, 1.09-1.97], and six or more [OR, 1.58; 95% CI, 1.09-2.30] of eight evaluated arterial segments). Conclusions: The association between NAFLD and arterial calcification is mainly mediated by conventional risk factors. The independent association between NAFLD and calcification in the thoracic aorta and celiac trunk as well as in a larger number of vascular beds needs confirmation in future prospective studies in diverse populations.

Original languageEnglish
Pages (from-to)204-211.e4
JournalJournal of Vascular Surgery
Volume71
Issue number1
DOIs
StatePublished - Jan 2020

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Atherosclerosis
Fats
Thoracic Aorta
Liver
Abdomen
Odds Ratio
Confidence Intervals
Blood Vessels
Coronary Vessels
Superior Mesenteric Artery
Carotid Arteries
Iliac Artery
Abdominal Aorta
Renal Artery
Dyslipidemias
Non-alcoholic Fatty Liver Disease
Heart Diseases
Chronic Disease
Obesity
Smoking

Keywords

  • Calcification
  • Celiac trunk
  • Nonalcoholic fatty liver disease
  • Systemic atherosclerosis
  • Thoracic aorta

Cite this

Koo, Bo Kyung ; Allison, Matthew A. ; Criqui, Michael H. ; Denenberg, Julie O. ; Wright, C. Michael. / The association between liver fat and systemic calcified atherosclerosis. In: Journal of Vascular Surgery. 2020 ; Vol. 71, No. 1. pp. 204-211.e4.
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abstract = "Background: The association of nonalcoholic fatty liver disease (NAFLD) with systemic calcified atherosclerosis, other than the coronary arteries, has not been clearly elucidated. We investigated the association between NAFLD and calcification in eight different vascular beds. Methods: In a community-based cohort with computed tomography scans for carotid artery, coronary artery, thoracic aorta, abdominal aorta, iliac artery, renal artery, celiac trunk, and superior mesenteric artery, the association between NAFLD and arterial calcification was evaluated with adjustment for age, sex, hypertension, dyslipidemia, diabetes, obesity, current smoking status, and family history of heart disease in the first-degree relatives. Results: In age- and sex-adjusted models, NAFLD was significantly associated with calcification in the coronary artery, carotid artery, thoracic aorta, celiac trunk, and superior mesenteric artery vascular beds (P <.05). However, adjustment for the traditional chronic venous disease risk factors attenuated the associations, except in the case of the thoracic aorta (odds ratio [OR], 1.38; 95{\%} confidence interval [CI], 1.09-1.78) and celiac trunk (OR, 2.05; 95{\%} CI, 1.16-3.65). In addition, NAFLD was independently associated with multiarterial calcification (four or more [OR, 1.33; 95{\%} CI, 1.01-1.74], five or more [OR, 1.46; 95{\%} CI, 1.09-1.97], and six or more [OR, 1.58; 95{\%} CI, 1.09-2.30] of eight evaluated arterial segments). Conclusions: The association between NAFLD and arterial calcification is mainly mediated by conventional risk factors. The independent association between NAFLD and calcification in the thoracic aorta and celiac trunk as well as in a larger number of vascular beds needs confirmation in future prospective studies in diverse populations.",
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Koo, BK, Allison, MA, Criqui, MH, Denenberg, JO & Wright, CM 2020, 'The association between liver fat and systemic calcified atherosclerosis', Journal of Vascular Surgery, vol. 71, no. 1, pp. 204-211.e4. https://doi.org/10.1016/j.jvs.2019.03.044

The association between liver fat and systemic calcified atherosclerosis. / Koo, Bo Kyung; Allison, Matthew A.; Criqui, Michael H.; Denenberg, Julie O.; Wright, C. Michael.

In: Journal of Vascular Surgery, Vol. 71, No. 1, 01.2020, p. 204-211.e4.

Research output: Contribution to journalArticle

TY - JOUR

T1 - The association between liver fat and systemic calcified atherosclerosis

AU - Koo, Bo Kyung

AU - Allison, Matthew A.

AU - Criqui, Michael H.

AU - Denenberg, Julie O.

AU - Wright, C. Michael

PY - 2020/1

Y1 - 2020/1

N2 - Background: The association of nonalcoholic fatty liver disease (NAFLD) with systemic calcified atherosclerosis, other than the coronary arteries, has not been clearly elucidated. We investigated the association between NAFLD and calcification in eight different vascular beds. Methods: In a community-based cohort with computed tomography scans for carotid artery, coronary artery, thoracic aorta, abdominal aorta, iliac artery, renal artery, celiac trunk, and superior mesenteric artery, the association between NAFLD and arterial calcification was evaluated with adjustment for age, sex, hypertension, dyslipidemia, diabetes, obesity, current smoking status, and family history of heart disease in the first-degree relatives. Results: In age- and sex-adjusted models, NAFLD was significantly associated with calcification in the coronary artery, carotid artery, thoracic aorta, celiac trunk, and superior mesenteric artery vascular beds (P <.05). However, adjustment for the traditional chronic venous disease risk factors attenuated the associations, except in the case of the thoracic aorta (odds ratio [OR], 1.38; 95% confidence interval [CI], 1.09-1.78) and celiac trunk (OR, 2.05; 95% CI, 1.16-3.65). In addition, NAFLD was independently associated with multiarterial calcification (four or more [OR, 1.33; 95% CI, 1.01-1.74], five or more [OR, 1.46; 95% CI, 1.09-1.97], and six or more [OR, 1.58; 95% CI, 1.09-2.30] of eight evaluated arterial segments). Conclusions: The association between NAFLD and arterial calcification is mainly mediated by conventional risk factors. The independent association between NAFLD and calcification in the thoracic aorta and celiac trunk as well as in a larger number of vascular beds needs confirmation in future prospective studies in diverse populations.

AB - Background: The association of nonalcoholic fatty liver disease (NAFLD) with systemic calcified atherosclerosis, other than the coronary arteries, has not been clearly elucidated. We investigated the association between NAFLD and calcification in eight different vascular beds. Methods: In a community-based cohort with computed tomography scans for carotid artery, coronary artery, thoracic aorta, abdominal aorta, iliac artery, renal artery, celiac trunk, and superior mesenteric artery, the association between NAFLD and arterial calcification was evaluated with adjustment for age, sex, hypertension, dyslipidemia, diabetes, obesity, current smoking status, and family history of heart disease in the first-degree relatives. Results: In age- and sex-adjusted models, NAFLD was significantly associated with calcification in the coronary artery, carotid artery, thoracic aorta, celiac trunk, and superior mesenteric artery vascular beds (P <.05). However, adjustment for the traditional chronic venous disease risk factors attenuated the associations, except in the case of the thoracic aorta (odds ratio [OR], 1.38; 95% confidence interval [CI], 1.09-1.78) and celiac trunk (OR, 2.05; 95% CI, 1.16-3.65). In addition, NAFLD was independently associated with multiarterial calcification (four or more [OR, 1.33; 95% CI, 1.01-1.74], five or more [OR, 1.46; 95% CI, 1.09-1.97], and six or more [OR, 1.58; 95% CI, 1.09-2.30] of eight evaluated arterial segments). Conclusions: The association between NAFLD and arterial calcification is mainly mediated by conventional risk factors. The independent association between NAFLD and calcification in the thoracic aorta and celiac trunk as well as in a larger number of vascular beds needs confirmation in future prospective studies in diverse populations.

KW - Calcification

KW - Celiac trunk

KW - Nonalcoholic fatty liver disease

KW - Systemic atherosclerosis

KW - Thoracic aorta

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