Targeting HIF-1α is a prerequisite for cell sensitivity to dichloroacetate (DCA) and metformin

Sung Eun Hong, Hyeon Ok Jin, Hyun Ah Kim, Min Ki Seong, Eun Kyu Kim, Sang Kyu Ye, Tae Boo Choe, Jin Kyung Lee, Jong Il Kim, In Chul Park, Woo Chul Noh

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Recently, targeting deregulated energy metabolism is an emerging strategy for cancer therapy. In the present study, combination of DCA and metformin markedly induced cell death, compared with each drug alone. Furthermore, the expression levels of glycolytic enzymes including HK2, LDHA and ENO1 were downregulated by two drugs. Interestingly, HIF-1α activation markedly suppressed DCA/metformin-induced cell death and recovered the expressions of glycolytic enzymes that were decreased by two drugs. Based on these findings, we propose that targeting HIF-1α is necessary for cancer metabolism targeted therapy.

Original languageEnglish
Pages (from-to)164-170
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume469
Issue number2
DOIs
StatePublished - 8 Jan 2016

Keywords

  • Cancer metabolism
  • Dichloroacetate
  • Glycolytic enzymes
  • HIF-1α
  • Metformin

Cite this

Hong, S. E., Jin, H. O., Kim, H. A., Seong, M. K., Kim, E. K., Ye, S. K., Choe, T. B., Lee, J. K., Kim, J. I., Park, I. C., & Noh, W. C. (2016). Targeting HIF-1α is a prerequisite for cell sensitivity to dichloroacetate (DCA) and metformin. Biochemical and Biophysical Research Communications, 469(2), 164-170. https://doi.org/10.1016/j.bbrc.2015.11.088