Target-organ damage and incident hypertension: The Korean genome and epidemiology study

Seong Hwan Kim, Yong Hyun Kim, Jin Seok Kim, Sang Yup Lim, Jae Hyun Jung, Hong Euy Lim, Eung Ju Kim, Goo Yeong Cho, Inkyung Baik, Ki Chul Sung, Juri Park, Seung Ku Lee, Chol Shin

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: Hypertension is associated with cardiovascular organ damage. However, data are scanty on whether individual forms or combinations of subclinical target organ damage (TOD) increase the risk of incident hypertension in nonhypertensive study participants. Methods: A total of 1785 nonhypertensive participants from the fourth biennial examination (2007-2008) of the Korean Genome and Epidemiology Study were followed-up for four years. Echocardiographic left ventricular (LV) hypertrophy, LV diastolic dysfunction, increased carotid intima-media thickness (cIMT), and brachial-ankle pulse wave velocity (baPWV) were defined according to the current guidelines. Results: During 4-year follow-up, 19.9% of participants developed hypertension. In multivariate Cox proportional hazards models, the adjusted hazard ratios for developing hypertension were 1.39, 1.66, 1.48, and 0.78 for higher values of the LV mass index, cIMT, baPWV, and tissue Doppler e′ velocity, respectively (all P<0.01). The hazard ratios for LV hypertrophy, LV diastolic dysfunction, cIMT >75th percentile, and baPWV ≥ 1400cm/s were 1.61, 1.30, 1.86, and 2.07, respectively (all P<0.05). Compared with participants without any TOD, those with combinations of TOD types had significantly greater risk for developing hypertension (hazard ratio=2.12 and 3.98 for 1-2 and 3-4 TOD sites, respectively, all P<0.001). Conclusion: In the nonhypertensive population, each subclinical form of TOD independently predicts incident hypertension. In addition, the combinations of various forms of TOD are associated with stepwise increases in the risk for developing hypertension. The results suggest that asymptomatic TOD does not always exist in an intermediate stage in the cardiovascular continuum.

Original languageEnglish
Pages (from-to)524-531
Number of pages8
JournalJournal of Hypertension
Volume34
Issue number3
DOIs
StatePublished - 1 Mar 2016

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Epidemiology
Genome
Hypertension
Pulse Wave Analysis
Ankle
Carotid Intima-Media Thickness
Arm
Left Ventricular Dysfunction
Left Ventricular Hypertrophy
Proportional Hazards Models
Guidelines
Population

Keywords

  • carotid intima-media thickness
  • diastolic function
  • hypertension
  • left ventricular hypertrophy
  • pulse wave velocity
  • target organ damage

Cite this

Kim, S. H., Kim, Y. H., Kim, J. S., Lim, S. Y., Jung, J. H., Lim, H. E., ... Shin, C. (2016). Target-organ damage and incident hypertension: The Korean genome and epidemiology study. Journal of Hypertension, 34(3), 524-531. https://doi.org/10.1097/HJH.0000000000000836
Kim, Seong Hwan ; Kim, Yong Hyun ; Kim, Jin Seok ; Lim, Sang Yup ; Jung, Jae Hyun ; Lim, Hong Euy ; Kim, Eung Ju ; Cho, Goo Yeong ; Baik, Inkyung ; Sung, Ki Chul ; Park, Juri ; Lee, Seung Ku ; Shin, Chol. / Target-organ damage and incident hypertension : The Korean genome and epidemiology study. In: Journal of Hypertension. 2016 ; Vol. 34, No. 3. pp. 524-531.
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abstract = "Objective: Hypertension is associated with cardiovascular organ damage. However, data are scanty on whether individual forms or combinations of subclinical target organ damage (TOD) increase the risk of incident hypertension in nonhypertensive study participants. Methods: A total of 1785 nonhypertensive participants from the fourth biennial examination (2007-2008) of the Korean Genome and Epidemiology Study were followed-up for four years. Echocardiographic left ventricular (LV) hypertrophy, LV diastolic dysfunction, increased carotid intima-media thickness (cIMT), and brachial-ankle pulse wave velocity (baPWV) were defined according to the current guidelines. Results: During 4-year follow-up, 19.9{\%} of participants developed hypertension. In multivariate Cox proportional hazards models, the adjusted hazard ratios for developing hypertension were 1.39, 1.66, 1.48, and 0.78 for higher values of the LV mass index, cIMT, baPWV, and tissue Doppler e′ velocity, respectively (all P<0.01). The hazard ratios for LV hypertrophy, LV diastolic dysfunction, cIMT >75th percentile, and baPWV ≥ 1400cm/s were 1.61, 1.30, 1.86, and 2.07, respectively (all P<0.05). Compared with participants without any TOD, those with combinations of TOD types had significantly greater risk for developing hypertension (hazard ratio=2.12 and 3.98 for 1-2 and 3-4 TOD sites, respectively, all P<0.001). Conclusion: In the nonhypertensive population, each subclinical form of TOD independently predicts incident hypertension. In addition, the combinations of various forms of TOD are associated with stepwise increases in the risk for developing hypertension. The results suggest that asymptomatic TOD does not always exist in an intermediate stage in the cardiovascular continuum.",
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author = "Kim, {Seong Hwan} and Kim, {Yong Hyun} and Kim, {Jin Seok} and Lim, {Sang Yup} and Jung, {Jae Hyun} and Lim, {Hong Euy} and Kim, {Eung Ju} and Cho, {Goo Yeong} and Inkyung Baik and Sung, {Ki Chul} and Juri Park and Lee, {Seung Ku} and Chol Shin",
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Kim, SH, Kim, YH, Kim, JS, Lim, SY, Jung, JH, Lim, HE, Kim, EJ, Cho, GY, Baik, I, Sung, KC, Park, J, Lee, SK & Shin, C 2016, 'Target-organ damage and incident hypertension: The Korean genome and epidemiology study', Journal of Hypertension, vol. 34, no. 3, pp. 524-531. https://doi.org/10.1097/HJH.0000000000000836

Target-organ damage and incident hypertension : The Korean genome and epidemiology study. / Kim, Seong Hwan; Kim, Yong Hyun; Kim, Jin Seok; Lim, Sang Yup; Jung, Jae Hyun; Lim, Hong Euy; Kim, Eung Ju; Cho, Goo Yeong; Baik, Inkyung; Sung, Ki Chul; Park, Juri; Lee, Seung Ku; Shin, Chol.

In: Journal of Hypertension, Vol. 34, No. 3, 01.03.2016, p. 524-531.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Target-organ damage and incident hypertension

T2 - The Korean genome and epidemiology study

AU - Kim, Seong Hwan

AU - Kim, Yong Hyun

AU - Kim, Jin Seok

AU - Lim, Sang Yup

AU - Jung, Jae Hyun

AU - Lim, Hong Euy

AU - Kim, Eung Ju

AU - Cho, Goo Yeong

AU - Baik, Inkyung

AU - Sung, Ki Chul

AU - Park, Juri

AU - Lee, Seung Ku

AU - Shin, Chol

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Objective: Hypertension is associated with cardiovascular organ damage. However, data are scanty on whether individual forms or combinations of subclinical target organ damage (TOD) increase the risk of incident hypertension in nonhypertensive study participants. Methods: A total of 1785 nonhypertensive participants from the fourth biennial examination (2007-2008) of the Korean Genome and Epidemiology Study were followed-up for four years. Echocardiographic left ventricular (LV) hypertrophy, LV diastolic dysfunction, increased carotid intima-media thickness (cIMT), and brachial-ankle pulse wave velocity (baPWV) were defined according to the current guidelines. Results: During 4-year follow-up, 19.9% of participants developed hypertension. In multivariate Cox proportional hazards models, the adjusted hazard ratios for developing hypertension were 1.39, 1.66, 1.48, and 0.78 for higher values of the LV mass index, cIMT, baPWV, and tissue Doppler e′ velocity, respectively (all P<0.01). The hazard ratios for LV hypertrophy, LV diastolic dysfunction, cIMT >75th percentile, and baPWV ≥ 1400cm/s were 1.61, 1.30, 1.86, and 2.07, respectively (all P<0.05). Compared with participants without any TOD, those with combinations of TOD types had significantly greater risk for developing hypertension (hazard ratio=2.12 and 3.98 for 1-2 and 3-4 TOD sites, respectively, all P<0.001). Conclusion: In the nonhypertensive population, each subclinical form of TOD independently predicts incident hypertension. In addition, the combinations of various forms of TOD are associated with stepwise increases in the risk for developing hypertension. The results suggest that asymptomatic TOD does not always exist in an intermediate stage in the cardiovascular continuum.

AB - Objective: Hypertension is associated with cardiovascular organ damage. However, data are scanty on whether individual forms or combinations of subclinical target organ damage (TOD) increase the risk of incident hypertension in nonhypertensive study participants. Methods: A total of 1785 nonhypertensive participants from the fourth biennial examination (2007-2008) of the Korean Genome and Epidemiology Study were followed-up for four years. Echocardiographic left ventricular (LV) hypertrophy, LV diastolic dysfunction, increased carotid intima-media thickness (cIMT), and brachial-ankle pulse wave velocity (baPWV) were defined according to the current guidelines. Results: During 4-year follow-up, 19.9% of participants developed hypertension. In multivariate Cox proportional hazards models, the adjusted hazard ratios for developing hypertension were 1.39, 1.66, 1.48, and 0.78 for higher values of the LV mass index, cIMT, baPWV, and tissue Doppler e′ velocity, respectively (all P<0.01). The hazard ratios for LV hypertrophy, LV diastolic dysfunction, cIMT >75th percentile, and baPWV ≥ 1400cm/s were 1.61, 1.30, 1.86, and 2.07, respectively (all P<0.05). Compared with participants without any TOD, those with combinations of TOD types had significantly greater risk for developing hypertension (hazard ratio=2.12 and 3.98 for 1-2 and 3-4 TOD sites, respectively, all P<0.001). Conclusion: In the nonhypertensive population, each subclinical form of TOD independently predicts incident hypertension. In addition, the combinations of various forms of TOD are associated with stepwise increases in the risk for developing hypertension. The results suggest that asymptomatic TOD does not always exist in an intermediate stage in the cardiovascular continuum.

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KW - diastolic function

KW - hypertension

KW - left ventricular hypertrophy

KW - pulse wave velocity

KW - target organ damage

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