Synthesis of uniformly sized manganese oxide nanocrystals with various sizes and shapes and characterization of their T 1 magnetic resonance relaxivity

Kwangjin An, Mihyun Park, Jung Ho Yu, Hyon Bin Na, Nohyun Lee, Jongnam Park, Seung Hong Choi, In Chan Song, Woo Kyung Moon, Taeghwan Hyeon

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

We synthesized manganese oxide (MnO and Mn 3O 4) nanocrystals with various sizes and shapes by the thermal reaction of a Mn II-oleate complex through a "heat-up process". When a Mn II-oleate complex was thermally decomposed in non-coordinating hydrocarbon solvents, uniformly sized MnO nanocrystals with cubic and octahedral shapes were produced. We were able to synthesize anisotropic, multibranched MnO nanocrystals by the oriented attachment of MnO truncated-nanocube building blocks. When the Mn II-oleate complex was heated in 1-hexadecene in the presence of strongly coordinating carboxylic acid surfactants, spherical nanocrystals were generated, and their diameter was controlled in the range 3-13 nm by varying the chain length of the carboxylic acid. When oleyl alcohol was added to the Mn-oleate complex in phenyl ether, tetrahedral MnO nanocrystals were synthesized. The as-synthesized MnO nanocrystals were oxidized in air to Mn 3O 4 or MnO/Mn 3O 4 core-shell structures, which exhibited exchange coupling with shifted magnetic hysteresis loops. The effect of the size and shape of the phospholipid-capped manganese oxide nanocrystals on their applicability as T 1 contrast agents in magnetic resonance imaging (MRI) were examined. As the size of the nanocrystals decreased, their relaxivities increased, thereby generating brighter MR images. In particular, spherical 3 nm-sized Mn 3O 4 nanocrystals had a high specific relaxivity (r 1) of 2.38 mM -1 s -1, clearly demonstrating their potential for use as an efficient T 1 MRI contrast agent. Manganese oxide nanocrystals with various sizes and shapes were synthesized by thermal decomposition of a Mn-oleate complex. The effect of the size and shape of the phospholipid-capped nanocrystalson their applicability as T 1 contrast agents in magnetic resonance imaging (MRI) was examined. As their size decreased, their specific relaxivities increased, which generated brighter MR images.

Original languageEnglish
Pages (from-to)2148-2155
Number of pages8
JournalEuropean Journal of Inorganic Chemistry
Issue number12
DOIs
StatePublished - 1 Apr 2012

Fingerprint

Magnetic resonance
Nanocrystals
Oleic Acid
Contrast Media
Carboxylic Acids
Imaging techniques
Phospholipids
manganese oxide
Magnetic hysteresis
Exchange coupling
Hysteresis loops
Hydrocarbons
Chain length
Surface-Active Agents
Pyrolysis

Keywords

  • Heat-up process
  • Imaging agents
  • Manganese
  • Nanoparticles
  • Thermal decomposition

Cite this

An, Kwangjin ; Park, Mihyun ; Yu, Jung Ho ; Na, Hyon Bin ; Lee, Nohyun ; Park, Jongnam ; Choi, Seung Hong ; Song, In Chan ; Moon, Woo Kyung ; Hyeon, Taeghwan. / Synthesis of uniformly sized manganese oxide nanocrystals with various sizes and shapes and characterization of their T 1 magnetic resonance relaxivity. In: European Journal of Inorganic Chemistry. 2012 ; No. 12. pp. 2148-2155.
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Synthesis of uniformly sized manganese oxide nanocrystals with various sizes and shapes and characterization of their T 1 magnetic resonance relaxivity. / An, Kwangjin; Park, Mihyun; Yu, Jung Ho; Na, Hyon Bin; Lee, Nohyun; Park, Jongnam; Choi, Seung Hong; Song, In Chan; Moon, Woo Kyung; Hyeon, Taeghwan.

In: European Journal of Inorganic Chemistry, No. 12, 01.04.2012, p. 2148-2155.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Synthesis of uniformly sized manganese oxide nanocrystals with various sizes and shapes and characterization of their T 1 magnetic resonance relaxivity

AU - An, Kwangjin

AU - Park, Mihyun

AU - Yu, Jung Ho

AU - Na, Hyon Bin

AU - Lee, Nohyun

AU - Park, Jongnam

AU - Choi, Seung Hong

AU - Song, In Chan

AU - Moon, Woo Kyung

AU - Hyeon, Taeghwan

PY - 2012/4/1

Y1 - 2012/4/1

N2 - We synthesized manganese oxide (MnO and Mn 3O 4) nanocrystals with various sizes and shapes by the thermal reaction of a Mn II-oleate complex through a "heat-up process". When a Mn II-oleate complex was thermally decomposed in non-coordinating hydrocarbon solvents, uniformly sized MnO nanocrystals with cubic and octahedral shapes were produced. We were able to synthesize anisotropic, multibranched MnO nanocrystals by the oriented attachment of MnO truncated-nanocube building blocks. When the Mn II-oleate complex was heated in 1-hexadecene in the presence of strongly coordinating carboxylic acid surfactants, spherical nanocrystals were generated, and their diameter was controlled in the range 3-13 nm by varying the chain length of the carboxylic acid. When oleyl alcohol was added to the Mn-oleate complex in phenyl ether, tetrahedral MnO nanocrystals were synthesized. The as-synthesized MnO nanocrystals were oxidized in air to Mn 3O 4 or MnO/Mn 3O 4 core-shell structures, which exhibited exchange coupling with shifted magnetic hysteresis loops. The effect of the size and shape of the phospholipid-capped manganese oxide nanocrystals on their applicability as T 1 contrast agents in magnetic resonance imaging (MRI) were examined. As the size of the nanocrystals decreased, their relaxivities increased, thereby generating brighter MR images. In particular, spherical 3 nm-sized Mn 3O 4 nanocrystals had a high specific relaxivity (r 1) of 2.38 mM -1 s -1, clearly demonstrating their potential for use as an efficient T 1 MRI contrast agent. Manganese oxide nanocrystals with various sizes and shapes were synthesized by thermal decomposition of a Mn-oleate complex. The effect of the size and shape of the phospholipid-capped nanocrystalson their applicability as T 1 contrast agents in magnetic resonance imaging (MRI) was examined. As their size decreased, their specific relaxivities increased, which generated brighter MR images.

AB - We synthesized manganese oxide (MnO and Mn 3O 4) nanocrystals with various sizes and shapes by the thermal reaction of a Mn II-oleate complex through a "heat-up process". When a Mn II-oleate complex was thermally decomposed in non-coordinating hydrocarbon solvents, uniformly sized MnO nanocrystals with cubic and octahedral shapes were produced. We were able to synthesize anisotropic, multibranched MnO nanocrystals by the oriented attachment of MnO truncated-nanocube building blocks. When the Mn II-oleate complex was heated in 1-hexadecene in the presence of strongly coordinating carboxylic acid surfactants, spherical nanocrystals were generated, and their diameter was controlled in the range 3-13 nm by varying the chain length of the carboxylic acid. When oleyl alcohol was added to the Mn-oleate complex in phenyl ether, tetrahedral MnO nanocrystals were synthesized. The as-synthesized MnO nanocrystals were oxidized in air to Mn 3O 4 or MnO/Mn 3O 4 core-shell structures, which exhibited exchange coupling with shifted magnetic hysteresis loops. The effect of the size and shape of the phospholipid-capped manganese oxide nanocrystals on their applicability as T 1 contrast agents in magnetic resonance imaging (MRI) were examined. As the size of the nanocrystals decreased, their relaxivities increased, thereby generating brighter MR images. In particular, spherical 3 nm-sized Mn 3O 4 nanocrystals had a high specific relaxivity (r 1) of 2.38 mM -1 s -1, clearly demonstrating their potential for use as an efficient T 1 MRI contrast agent. Manganese oxide nanocrystals with various sizes and shapes were synthesized by thermal decomposition of a Mn-oleate complex. The effect of the size and shape of the phospholipid-capped nanocrystalson their applicability as T 1 contrast agents in magnetic resonance imaging (MRI) was examined. As their size decreased, their specific relaxivities increased, which generated brighter MR images.

KW - Heat-up process

KW - Imaging agents

KW - Manganese

KW - Nanoparticles

KW - Thermal decomposition

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