Synthesis of gold nanoparticles by electro-reduction method and their application as an electro-hyperthermia system

Young Il Yoon, Kwang Soo Kim, Yong Soo Kwon, Hee Sang Cho, Hak Jong Lee, Chang Jin Yoon, Tae Jong Yoon

Research output: Contribution to journalArticlepeer-review

Abstract

We report the successful preparation of gold nanoparticles (Au NPs) using a novel electroreduction process, which is simple, fast, and environmentally friendly (toxic chemicals such as strong reducing agents are not required). Our process allows for the mass production of Au NPs and adequate particle size control. The Au NPs prepared show high biocompatibility and are non-toxic to healthy human cells. By applying radio-frequency (RF) ablation, we monitored the electro-hyperthermia effect of the Au NPs at different RFs. The Au NPs exhibit a fast increase in temperature to 55 °C within 5 min during the application of an RF of 13 MHz. This temperature rise is sufficient to promote apoptosis through thermal stress. Our work suggests that the selective Au NP-mediated electro-hyperthermia therapy for tumor cells under an RF of 13 MHz has great potential as a clinical treatment for specific tumor ablation.

Original languageEnglish
Pages (from-to)1806-1808
Number of pages3
JournalBulletin of the Korean Chemical Society
Volume35
Issue number6
DOIs
StatePublished - 20 Jun 2014

Keywords

  • Biocompatible nanomaterials
  • Electro-hyperthermia
  • Gold nanoparticles
  • Heat shock
  • Radiofrequency ablation

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