Synergistic effect of viral load and alcohol consumption on the risk of persistent high-risk human papillomavirus infection

Hea Young Oh, Sang Soo Seo, Mi Kyung Kim, Dong Ock Lee, Youn Kyung Chung, Myong Cheol Lim, Joo Young Kim, Chan Wha Lee, Sang Yoon Park

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Abstract

Purpose: This prospective study aimed to examine the combined effect of viral load and alcohol consumption on the risk of persistent high-risk (HR) human papillomavirus (HPV) infection. Methods: Among women undergoing health screening between 2002 and 2011 at the National Cancer Center, 284 and 122 women with HR-HPV infection and cytological findings of low-grade squamous intraepithelial or lower-grade lesions were followed up for 1 and 2 years, respectively. Multivariate logistic regression analysis was performed, and the relative excess risk due to interaction (RERI) and synergy index (S) were calculated. Results: Among drinkers, the risks of 1-year (odds ratio [OR] 4.09, 95% confidence interval [CI] 2.05-8.18) and 2-year persistence (OR 8.08, CI 2.36-27.6) were significantly higher for high HPV loads than for low HPV loads; this association was not seen for non-drinkers. The risks for 1-year (OR 4.14, CI 1.89-9.05) and 2-year persistence (OR 6.61, CI 2.09-20.9) were significantly higher in subjects with a high HPV load who were also drinkers than in those who were non-drinkers. A high HPV load together with a longer drinking duration or higher alcohol consumption was associated with increased risks of 1-year (OR 3.07, CI 1.40-6.75 or OR 2.05, CI 0.87-4.83) and 2-year persistence (OR 6.40, CI 1.72-23.8 or OR 4.14, CI 1.18-14.6). The synergistic effect of alcohol consumption and HR-HPV load was stronger on the risk of 2-year persistence (RERI = 3.26, S = 2.38) than on the risk of 1-year persistence (RERI = 1.21, S = 1.63). Conclusions: The synergistic effect of HR-HPV load and alcohol consumption was associated with the risk of HR-HPV persistence and was stronger for longer-term HR-HPV infection. Limiting alcohol consumption might be an important measure to prevent the development of cervical cancer in women with a high HR-HPV load.

Original languageEnglish
Article numbere104374
JournalPLoS ONE
Volume9
Issue number8
DOIs
StatePublished - 20 Aug 2014

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Papillomavirus Infections
Papillomaviridae
viral load
Viral Load
Alcohol Drinking
Alcohols
infection
odds ratio
confidence interval
Odds Ratio
Confidence Intervals
alcohol drinking
women's health
uterine cervical neoplasms
Women's Health
prospective studies

Cite this

Oh, Hea Young ; Seo, Sang Soo ; Kim, Mi Kyung ; Lee, Dong Ock ; Chung, Youn Kyung ; Lim, Myong Cheol ; Kim, Joo Young ; Lee, Chan Wha ; Park, Sang Yoon. / Synergistic effect of viral load and alcohol consumption on the risk of persistent high-risk human papillomavirus infection. In: PLoS ONE. 2014 ; Vol. 9, No. 8.
@article{dabaa2ed737040b3a1c522a32209aa5d,
title = "Synergistic effect of viral load and alcohol consumption on the risk of persistent high-risk human papillomavirus infection",
abstract = "Purpose: This prospective study aimed to examine the combined effect of viral load and alcohol consumption on the risk of persistent high-risk (HR) human papillomavirus (HPV) infection. Methods: Among women undergoing health screening between 2002 and 2011 at the National Cancer Center, 284 and 122 women with HR-HPV infection and cytological findings of low-grade squamous intraepithelial or lower-grade lesions were followed up for 1 and 2 years, respectively. Multivariate logistic regression analysis was performed, and the relative excess risk due to interaction (RERI) and synergy index (S) were calculated. Results: Among drinkers, the risks of 1-year (odds ratio [OR] 4.09, 95{\%} confidence interval [CI] 2.05-8.18) and 2-year persistence (OR 8.08, CI 2.36-27.6) were significantly higher for high HPV loads than for low HPV loads; this association was not seen for non-drinkers. The risks for 1-year (OR 4.14, CI 1.89-9.05) and 2-year persistence (OR 6.61, CI 2.09-20.9) were significantly higher in subjects with a high HPV load who were also drinkers than in those who were non-drinkers. A high HPV load together with a longer drinking duration or higher alcohol consumption was associated with increased risks of 1-year (OR 3.07, CI 1.40-6.75 or OR 2.05, CI 0.87-4.83) and 2-year persistence (OR 6.40, CI 1.72-23.8 or OR 4.14, CI 1.18-14.6). The synergistic effect of alcohol consumption and HR-HPV load was stronger on the risk of 2-year persistence (RERI = 3.26, S = 2.38) than on the risk of 1-year persistence (RERI = 1.21, S = 1.63). Conclusions: The synergistic effect of HR-HPV load and alcohol consumption was associated with the risk of HR-HPV persistence and was stronger for longer-term HR-HPV infection. Limiting alcohol consumption might be an important measure to prevent the development of cervical cancer in women with a high HR-HPV load.",
author = "Oh, {Hea Young} and Seo, {Sang Soo} and Kim, {Mi Kyung} and Lee, {Dong Ock} and Chung, {Youn Kyung} and Lim, {Myong Cheol} and Kim, {Joo Young} and Lee, {Chan Wha} and Park, {Sang Yoon}",
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Synergistic effect of viral load and alcohol consumption on the risk of persistent high-risk human papillomavirus infection. / Oh, Hea Young; Seo, Sang Soo; Kim, Mi Kyung; Lee, Dong Ock; Chung, Youn Kyung; Lim, Myong Cheol; Kim, Joo Young; Lee, Chan Wha; Park, Sang Yoon.

In: PLoS ONE, Vol. 9, No. 8, e104374, 20.08.2014.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Synergistic effect of viral load and alcohol consumption on the risk of persistent high-risk human papillomavirus infection

AU - Oh, Hea Young

AU - Seo, Sang Soo

AU - Kim, Mi Kyung

AU - Lee, Dong Ock

AU - Chung, Youn Kyung

AU - Lim, Myong Cheol

AU - Kim, Joo Young

AU - Lee, Chan Wha

AU - Park, Sang Yoon

PY - 2014/8/20

Y1 - 2014/8/20

N2 - Purpose: This prospective study aimed to examine the combined effect of viral load and alcohol consumption on the risk of persistent high-risk (HR) human papillomavirus (HPV) infection. Methods: Among women undergoing health screening between 2002 and 2011 at the National Cancer Center, 284 and 122 women with HR-HPV infection and cytological findings of low-grade squamous intraepithelial or lower-grade lesions were followed up for 1 and 2 years, respectively. Multivariate logistic regression analysis was performed, and the relative excess risk due to interaction (RERI) and synergy index (S) were calculated. Results: Among drinkers, the risks of 1-year (odds ratio [OR] 4.09, 95% confidence interval [CI] 2.05-8.18) and 2-year persistence (OR 8.08, CI 2.36-27.6) were significantly higher for high HPV loads than for low HPV loads; this association was not seen for non-drinkers. The risks for 1-year (OR 4.14, CI 1.89-9.05) and 2-year persistence (OR 6.61, CI 2.09-20.9) were significantly higher in subjects with a high HPV load who were also drinkers than in those who were non-drinkers. A high HPV load together with a longer drinking duration or higher alcohol consumption was associated with increased risks of 1-year (OR 3.07, CI 1.40-6.75 or OR 2.05, CI 0.87-4.83) and 2-year persistence (OR 6.40, CI 1.72-23.8 or OR 4.14, CI 1.18-14.6). The synergistic effect of alcohol consumption and HR-HPV load was stronger on the risk of 2-year persistence (RERI = 3.26, S = 2.38) than on the risk of 1-year persistence (RERI = 1.21, S = 1.63). Conclusions: The synergistic effect of HR-HPV load and alcohol consumption was associated with the risk of HR-HPV persistence and was stronger for longer-term HR-HPV infection. Limiting alcohol consumption might be an important measure to prevent the development of cervical cancer in women with a high HR-HPV load.

AB - Purpose: This prospective study aimed to examine the combined effect of viral load and alcohol consumption on the risk of persistent high-risk (HR) human papillomavirus (HPV) infection. Methods: Among women undergoing health screening between 2002 and 2011 at the National Cancer Center, 284 and 122 women with HR-HPV infection and cytological findings of low-grade squamous intraepithelial or lower-grade lesions were followed up for 1 and 2 years, respectively. Multivariate logistic regression analysis was performed, and the relative excess risk due to interaction (RERI) and synergy index (S) were calculated. Results: Among drinkers, the risks of 1-year (odds ratio [OR] 4.09, 95% confidence interval [CI] 2.05-8.18) and 2-year persistence (OR 8.08, CI 2.36-27.6) were significantly higher for high HPV loads than for low HPV loads; this association was not seen for non-drinkers. The risks for 1-year (OR 4.14, CI 1.89-9.05) and 2-year persistence (OR 6.61, CI 2.09-20.9) were significantly higher in subjects with a high HPV load who were also drinkers than in those who were non-drinkers. A high HPV load together with a longer drinking duration or higher alcohol consumption was associated with increased risks of 1-year (OR 3.07, CI 1.40-6.75 or OR 2.05, CI 0.87-4.83) and 2-year persistence (OR 6.40, CI 1.72-23.8 or OR 4.14, CI 1.18-14.6). The synergistic effect of alcohol consumption and HR-HPV load was stronger on the risk of 2-year persistence (RERI = 3.26, S = 2.38) than on the risk of 1-year persistence (RERI = 1.21, S = 1.63). Conclusions: The synergistic effect of HR-HPV load and alcohol consumption was associated with the risk of HR-HPV persistence and was stronger for longer-term HR-HPV infection. Limiting alcohol consumption might be an important measure to prevent the development of cervical cancer in women with a high HR-HPV load.

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U2 - 10.1371/journal.pone.0104374

DO - 10.1371/journal.pone.0104374

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JO - PloS one

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SN - 1932-6203

IS - 8

M1 - e104374

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