Surface coating for prevention of metallic seed migration in tissues

Hyunseok Lee, Won Seok Lee, Jong In Park, Kwang Jae Son, Min Park, Young Bong Bang, Young Bin Choy, Sung Joon Ye

Research output: Contribution to journalArticle

2 Scopus citations


Purpose: In radiotherapy, metallic implants often detach from their deposited sites and migrate to other locations. This undesirable migration could cause inadequate dose coverage for permanent brachytherapy and difficulties in image-guided radiation delivery for patients. To prevent migration of implanted seeds, the authors propose a potential strategy to use a biocompatible and tissue-adhesive material called polydopamine. Methods: In this study, nonradioactive dummy seeds that have the same geometry and composition as commercial I-125 seeds were coated in polydopamine. Using scanning electron microscopy and x-ray photoelectron spectroscopy, the surface of the polydopamine-coated and noncoated seeds was characterized. The detachment stress between the two types of seeds and the tissue was measured. The efficacy of polydopamine-coated seed was investigated through in vitro migration tests by tracing the seed location after tissue implantation and shaking for given times. The cytotoxicity of the polydopamine coating was also evaluated. Results: The results of the coating characterization have shown that polydopamine was successfully coated on the surface of the seeds. In the adhesion test, the polydopamine-coated seeds had 2.1-fold greater detachment stress than noncoated seeds. From the in vitro test, it was determined that the polydopamine-coated seed migrated shorter distances than the noncoated seed. This difference was increased with a greater length of time after implantation. Conclusions: The authors suggest that polydopamine coating is an effective technique to prevent migration of implanted seeds, especially for permanent prostate brachytherapy.

Original languageEnglish
Pages (from-to)2805-2812
Number of pages8
JournalMedical Physics
Issue number6
StatePublished - 1 Jun 2015


  • brachytherapy
  • metallic implant
  • migration
  • polydopamine

Cite this

Lee, H., Lee, W. S., Park, J. I., Son, K. J., Park, M., Bang, Y. B., Choy, Y. B., & Ye, S. J. (2015). Surface coating for prevention of metallic seed migration in tissues. Medical Physics, 42(6), 2805-2812.