Supratentorial Cerebral Arterial Territories for Computed Tomograms: A Mapping Study in 1160 Large Artery Infarcts

Dong Eog Kim, Jinseong Jang, Dawid Schellingerhout, Wi Sun Ryu, Jong Ho Park, Su Kyoung Lee, Dongmin Kim, Hee-Joon Bae

Research output: Contribution to journalArticle

Abstract

We recently generated a high-resolution supratentorial vascular topographic atlas using diffusion-weighed MRI in a population of large artery infarcts. These MRI-based topographic maps are not easily applicable to CT scans, because the standard-reference-lines for axial image orientation (i.e., anterior-posterior commissure line versus orbito-meatal line, respectively) are ‘not parallel’ to each other. Moreover, current, widely-used CT-based vascular topographic diagrams omit demarcation of the inter-territorial border-zones. Thus, we aimed to generate a CT-specific high-resolution atlas, showing the supratentorial cerebrovascular territories and the inter-territorial border-zones in a statistically rigorous way. The diffusion-weighted MRI lesion atlas is based on 1160 patients (67.0 ± 13.3 years old, 53.7% men) with acute (<1-week) cerebral infarction due to significant (>50%) stenosis or occlusion of a single large cerebral artery: anterior, middle, or posterior cerebral artery. We developed a software package enabling the transformation of our MR-based atlas into a re-oriented CT space corresponding to the axial slice orientations used in clinical practice. Infarct volumes are individually mapped to the three vascular territories on the CT template-set, generating brain maps showing the voxelwise frequency of infarct by the affected parent vessel. We then mapped the three vascular territories collectively, generating a dataset of Certainty-Index (CI) maps to reflect the likelihood of a voxel being a member of a specific vascular territory. Border-zones could be defined by using either relative infarct frequencies or CI differences. The topographic vascular territory atlas, revised for CT, will allow for easier and more accurate delineation of arterial territories and borders on CT images.

Original languageEnglish
Article number11708
JournalScientific Reports
Volume9
Issue number1
DOIs
StatePublished - 1 Dec 2019

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Atlases
Blood Vessels
Arteries
Diffusion Magnetic Resonance Imaging
Posterior Cerebral Artery
Anterior Cerebral Artery
Middle Cerebral Artery
Pathologic Constriction
Software
Brain
Population

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Kim, Dong Eog ; Jang, Jinseong ; Schellingerhout, Dawid ; Ryu, Wi Sun ; Park, Jong Ho ; Lee, Su Kyoung ; Kim, Dongmin ; Bae, Hee-Joon. / Supratentorial Cerebral Arterial Territories for Computed Tomograms : A Mapping Study in 1160 Large Artery Infarcts. In: Scientific Reports. 2019 ; Vol. 9, No. 1.
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abstract = "We recently generated a high-resolution supratentorial vascular topographic atlas using diffusion-weighed MRI in a population of large artery infarcts. These MRI-based topographic maps are not easily applicable to CT scans, because the standard-reference-lines for axial image orientation (i.e., anterior-posterior commissure line versus orbito-meatal line, respectively) are ‘not parallel’ to each other. Moreover, current, widely-used CT-based vascular topographic diagrams omit demarcation of the inter-territorial border-zones. Thus, we aimed to generate a CT-specific high-resolution atlas, showing the supratentorial cerebrovascular territories and the inter-territorial border-zones in a statistically rigorous way. The diffusion-weighted MRI lesion atlas is based on 1160 patients (67.0 ± 13.3 years old, 53.7{\%} men) with acute (<1-week) cerebral infarction due to significant (>50{\%}) stenosis or occlusion of a single large cerebral artery: anterior, middle, or posterior cerebral artery. We developed a software package enabling the transformation of our MR-based atlas into a re-oriented CT space corresponding to the axial slice orientations used in clinical practice. Infarct volumes are individually mapped to the three vascular territories on the CT template-set, generating brain maps showing the voxelwise frequency of infarct by the affected parent vessel. We then mapped the three vascular territories collectively, generating a dataset of Certainty-Index (CI) maps to reflect the likelihood of a voxel being a member of a specific vascular territory. Border-zones could be defined by using either relative infarct frequencies or CI differences. The topographic vascular territory atlas, revised for CT, will allow for easier and more accurate delineation of arterial territories and borders on CT images.",
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Supratentorial Cerebral Arterial Territories for Computed Tomograms : A Mapping Study in 1160 Large Artery Infarcts. / Kim, Dong Eog; Jang, Jinseong; Schellingerhout, Dawid; Ryu, Wi Sun; Park, Jong Ho; Lee, Su Kyoung; Kim, Dongmin; Bae, Hee-Joon.

In: Scientific Reports, Vol. 9, No. 1, 11708, 01.12.2019.

Research output: Contribution to journalArticle

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AU - Ryu, Wi Sun

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AU - Lee, Su Kyoung

AU - Kim, Dongmin

AU - Bae, Hee-Joon

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