Supranormal differential renal function is real but may be pathological: Assessment by 99mtechnetium mercaptoacetyltriglycine renal scan of congenital unilateral hydronephrosis

Seung-June Oh, Hyuk Moon Dae Hyuk Moon, W. Kang, Seo Park Young Seo Park, T. Park, Suk Kim Kun Suk Kim

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Purpose: It is unclear whether supranormal differential renal function of the hydronephrotic kidney is real or artifactual. We investigated the effect of clinical and renographic parameters on differential renal function. Materials and Methods: The study included 34 males and 10 females from 1 to 9 months old (median age 2.6 months) with unilateral congenital hydronephrosis. A 99mtechnetium (Tc) mercaptoacetyltriglycine (MAG3) scan was performed, and regions of interest were drawn on the kidneys, and perirenal and lateral backgrounds. Differential renal function was calculated with and without background subtraction at 30-second intervals from 0.5 to 3 minutes after injection of 99mTc-MAG3. The effects of age, sex, obstruction, site and size of the hydronephrotic kidney were analyzed using the generalized estimating equations method. Results: There were 11 right and 33 left hydronephrotic kidneys. An obstructive renographic pattern was present in 33 cases. The trends of differential renal function according to intervals were different between kidneys with and without background subtraction, and differential renal function increased significantly as size increased (p <0.05). Differential renal function of the hydronephrotic kidney with an obstructive renographic pattern increased with time when perirenal or no background subtraction was applied (p <0.05). The effects of age, sex or laterality on differential renal function were not significant. Supranormal function (differential renal function 55% or greater) was present regardless of background subtraction methods and measurement time. Conclusions: Differential renal function is higher in larger hydronephrotic kidney but function of the kidney with an obstructive pattern is overestimated on later phases of 99mTc-MAG3 renal scan. Supranormal differential renal function is real and may be pathologic since it is prone to occur in larger obstructive hydronephrotic kidneys.

Original languageEnglish
Pages (from-to)2300-2304
Number of pages5
JournalJournal of Urology
Volume165
Issue number6 II SUPPL.
StatePublished - 21 May 2001

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Hydronephrosis
Kidney
Technetium Tc 99m Mertiatide

Keywords

  • Hydronephrosis
  • Kidney
  • Radioisotope renography
  • Technetium Tc 99m mertiatide

Cite this

Oh, Seung-June ; Dae Hyuk Moon, Hyuk Moon ; Kang, W. ; Young Seo Park, Seo Park ; Park, T. ; Kun Suk Kim, Suk Kim. / Supranormal differential renal function is real but may be pathological : Assessment by 99mtechnetium mercaptoacetyltriglycine renal scan of congenital unilateral hydronephrosis. In: Journal of Urology. 2001 ; Vol. 165, No. 6 II SUPPL. pp. 2300-2304.
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title = "Supranormal differential renal function is real but may be pathological: Assessment by 99mtechnetium mercaptoacetyltriglycine renal scan of congenital unilateral hydronephrosis",
abstract = "Purpose: It is unclear whether supranormal differential renal function of the hydronephrotic kidney is real or artifactual. We investigated the effect of clinical and renographic parameters on differential renal function. Materials and Methods: The study included 34 males and 10 females from 1 to 9 months old (median age 2.6 months) with unilateral congenital hydronephrosis. A 99mtechnetium (Tc) mercaptoacetyltriglycine (MAG3) scan was performed, and regions of interest were drawn on the kidneys, and perirenal and lateral backgrounds. Differential renal function was calculated with and without background subtraction at 30-second intervals from 0.5 to 3 minutes after injection of 99mTc-MAG3. The effects of age, sex, obstruction, site and size of the hydronephrotic kidney were analyzed using the generalized estimating equations method. Results: There were 11 right and 33 left hydronephrotic kidneys. An obstructive renographic pattern was present in 33 cases. The trends of differential renal function according to intervals were different between kidneys with and without background subtraction, and differential renal function increased significantly as size increased (p <0.05). Differential renal function of the hydronephrotic kidney with an obstructive renographic pattern increased with time when perirenal or no background subtraction was applied (p <0.05). The effects of age, sex or laterality on differential renal function were not significant. Supranormal function (differential renal function 55{\%} or greater) was present regardless of background subtraction methods and measurement time. Conclusions: Differential renal function is higher in larger hydronephrotic kidney but function of the kidney with an obstructive pattern is overestimated on later phases of 99mTc-MAG3 renal scan. Supranormal differential renal function is real and may be pathologic since it is prone to occur in larger obstructive hydronephrotic kidneys.",
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Supranormal differential renal function is real but may be pathological : Assessment by 99mtechnetium mercaptoacetyltriglycine renal scan of congenital unilateral hydronephrosis. / Oh, Seung-June; Dae Hyuk Moon, Hyuk Moon; Kang, W.; Young Seo Park, Seo Park; Park, T.; Kun Suk Kim, Suk Kim.

In: Journal of Urology, Vol. 165, No. 6 II SUPPL., 21.05.2001, p. 2300-2304.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Supranormal differential renal function is real but may be pathological

T2 - Assessment by 99mtechnetium mercaptoacetyltriglycine renal scan of congenital unilateral hydronephrosis

AU - Oh, Seung-June

AU - Dae Hyuk Moon, Hyuk Moon

AU - Kang, W.

AU - Young Seo Park, Seo Park

AU - Park, T.

AU - Kun Suk Kim, Suk Kim

PY - 2001/5/21

Y1 - 2001/5/21

N2 - Purpose: It is unclear whether supranormal differential renal function of the hydronephrotic kidney is real or artifactual. We investigated the effect of clinical and renographic parameters on differential renal function. Materials and Methods: The study included 34 males and 10 females from 1 to 9 months old (median age 2.6 months) with unilateral congenital hydronephrosis. A 99mtechnetium (Tc) mercaptoacetyltriglycine (MAG3) scan was performed, and regions of interest were drawn on the kidneys, and perirenal and lateral backgrounds. Differential renal function was calculated with and without background subtraction at 30-second intervals from 0.5 to 3 minutes after injection of 99mTc-MAG3. The effects of age, sex, obstruction, site and size of the hydronephrotic kidney were analyzed using the generalized estimating equations method. Results: There were 11 right and 33 left hydronephrotic kidneys. An obstructive renographic pattern was present in 33 cases. The trends of differential renal function according to intervals were different between kidneys with and without background subtraction, and differential renal function increased significantly as size increased (p <0.05). Differential renal function of the hydronephrotic kidney with an obstructive renographic pattern increased with time when perirenal or no background subtraction was applied (p <0.05). The effects of age, sex or laterality on differential renal function were not significant. Supranormal function (differential renal function 55% or greater) was present regardless of background subtraction methods and measurement time. Conclusions: Differential renal function is higher in larger hydronephrotic kidney but function of the kidney with an obstructive pattern is overestimated on later phases of 99mTc-MAG3 renal scan. Supranormal differential renal function is real and may be pathologic since it is prone to occur in larger obstructive hydronephrotic kidneys.

AB - Purpose: It is unclear whether supranormal differential renal function of the hydronephrotic kidney is real or artifactual. We investigated the effect of clinical and renographic parameters on differential renal function. Materials and Methods: The study included 34 males and 10 females from 1 to 9 months old (median age 2.6 months) with unilateral congenital hydronephrosis. A 99mtechnetium (Tc) mercaptoacetyltriglycine (MAG3) scan was performed, and regions of interest were drawn on the kidneys, and perirenal and lateral backgrounds. Differential renal function was calculated with and without background subtraction at 30-second intervals from 0.5 to 3 minutes after injection of 99mTc-MAG3. The effects of age, sex, obstruction, site and size of the hydronephrotic kidney were analyzed using the generalized estimating equations method. Results: There were 11 right and 33 left hydronephrotic kidneys. An obstructive renographic pattern was present in 33 cases. The trends of differential renal function according to intervals were different between kidneys with and without background subtraction, and differential renal function increased significantly as size increased (p <0.05). Differential renal function of the hydronephrotic kidney with an obstructive renographic pattern increased with time when perirenal or no background subtraction was applied (p <0.05). The effects of age, sex or laterality on differential renal function were not significant. Supranormal function (differential renal function 55% or greater) was present regardless of background subtraction methods and measurement time. Conclusions: Differential renal function is higher in larger hydronephrotic kidney but function of the kidney with an obstructive pattern is overestimated on later phases of 99mTc-MAG3 renal scan. Supranormal differential renal function is real and may be pathologic since it is prone to occur in larger obstructive hydronephrotic kidneys.

KW - Hydronephrosis

KW - Kidney

KW - Radioisotope renography

KW - Technetium Tc 99m mertiatide

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