Structure-Function Relationship in Patients with Retinitis Pigmentosa and Hyperautofluorescent Rings

Soung Jun Kim, Chae Hyun Song, Kun Ho Bae, Chang Ki Yoon, Un Chul Park, Eun Kyoung Lee

Research output: Contribution to journalArticlepeer-review

Abstract

This study aimed to investigate the association between retinal sensitivity and retinal microstructures in fundus autofluorescence (FAF) and optical coherence tomography (OCT) in patients with retinitis pigmentosa (RP) and hyperautofluorescent (hyperAF) rings. This cross-sectional study included 44 eyes from 26 consecutive patients with RP. The morphological geometry of the hyperAF ring, such as three distinct FAF regions, hyperAF ring area, and longest diameter of the hyperAF ring on FAF, and the retinal microstructure, such as total retinal thickness (TRT) and outer retinal thickness (ORT), on OCT, were evaluated. A strong correlation of mean retinal sensitivity with hyperAF ring area (R = 0.8013, p < 0.001) and longest diameter of the hyperAF ring (R = 0.9072, p < 0.001) was observed. Segmented linear regression (SLR) analysis revealed breakpoints of 12.83 mm2 and 5.21 mm, respectively. ORT (R = 0.6551, p < 0.001) was more strongly correlated with retinal sensitivity than TRT (R = 0.2732, p < 0.001). SLR analysis revealed a breakpoint between the ORT and retinal sensitivity of 145.12 μm. In patients with RP and hyperAF rings, retinal sensitivity was strongly associated with the morphological geometry of the hyperAF ring. ORT, rather than TRT, strongly correlated with retinal sensitivity.

Original languageEnglish
Article number5137
JournalJournal of Clinical Medicine
Volume11
Issue number17
DOIs
StatePublished - Sep 2022
Externally publishedYes

Keywords

  • fundus autofluorescence
  • hyperautofluorescent ring
  • optical coherence tomography
  • outer retinal thickness
  • retinitis pigmentosa
  • segmented linear regression

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