Steroid receptor expressions in endometrial cancer: Clinical significance and epidemiological implication

Yong Tark Jeon, Inae Park, Yong Beom Kim, Jae-Weon Kim, Nohhyun Park, Soon Beom Kang, Hyo Pyo Lee, Yong-Sang Song

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The evaluation of expression levels of the estrogen receptor (ER) and progesterone receptor (PR) in endometrial cancer is a very common procedure in modern practice. However, the significance of such tests remains controversial, and the evaluation of the status of steroid receptors seems to be a more thoroughly justified practice. The present study was carried out with 145 endometrial cancer patients, all of whom had undergone operations at the Seoul National University Hospital, from 1993 to 2002. Paraffin-embedded tissue blocks were sectioned and immunostained with monoclonal anti-ER and anti-PR antibodies. Clinicopathological variables were also analyzed, with 10% cutoff values for ER and PR positivity. A multivariate Cox regression analysis was performed in order to estimate the influences of several clinicopathological and immunohistochemical covariates on patient survival. Forty seven specimens (32.4%) stained as ER positive, and 110 (75.9%) stained as PR-positive. Patients with PR-positive tumor tended to be both younger and more obese than patients with PR-negative tumors (P=0.020, 0.016). Well-differentiated tumors were found to be positive for ER or PR more frequently (P=0.015, <0.001). ER or PR-positive tumors exhibited significantly less myometrial invasion (P=0.042, 0.002). However, multivariate Cox regression analyses revealed that the expressions of ER and PR were not significantly associated with patient survival, and only advanced FIGO stage constituted an independent prognostic factor. Our results suggested that the evaluation of steroid receptors might prove helpful prior to surgery. Low ER and high PR values suggest that racial differences and/or sequential loss of receptors during carcinogenesis might be involved in the expression of steroid receptors in cases of endometrial cancer.

Original languageEnglish
Pages (from-to)198-204
Number of pages7
JournalCancer Letters
Volume239
Issue number2
DOIs
StatePublished - 8 Aug 2006

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Steroid Receptors
Progesterone Receptors
Endometrial Neoplasms
Estrogen Receptors
Neoplasms
Regression Analysis
Survival
Paraffin
Carcinogenesis
Antibodies

Keywords

  • Endometrial cancer
  • Estrogen receptor
  • Progesterone receptor

Cite this

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title = "Steroid receptor expressions in endometrial cancer: Clinical significance and epidemiological implication",
abstract = "The evaluation of expression levels of the estrogen receptor (ER) and progesterone receptor (PR) in endometrial cancer is a very common procedure in modern practice. However, the significance of such tests remains controversial, and the evaluation of the status of steroid receptors seems to be a more thoroughly justified practice. The present study was carried out with 145 endometrial cancer patients, all of whom had undergone operations at the Seoul National University Hospital, from 1993 to 2002. Paraffin-embedded tissue blocks were sectioned and immunostained with monoclonal anti-ER and anti-PR antibodies. Clinicopathological variables were also analyzed, with 10{\%} cutoff values for ER and PR positivity. A multivariate Cox regression analysis was performed in order to estimate the influences of several clinicopathological and immunohistochemical covariates on patient survival. Forty seven specimens (32.4{\%}) stained as ER positive, and 110 (75.9{\%}) stained as PR-positive. Patients with PR-positive tumor tended to be both younger and more obese than patients with PR-negative tumors (P=0.020, 0.016). Well-differentiated tumors were found to be positive for ER or PR more frequently (P=0.015, <0.001). ER or PR-positive tumors exhibited significantly less myometrial invasion (P=0.042, 0.002). However, multivariate Cox regression analyses revealed that the expressions of ER and PR were not significantly associated with patient survival, and only advanced FIGO stage constituted an independent prognostic factor. Our results suggested that the evaluation of steroid receptors might prove helpful prior to surgery. Low ER and high PR values suggest that racial differences and/or sequential loss of receptors during carcinogenesis might be involved in the expression of steroid receptors in cases of endometrial cancer.",
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Steroid receptor expressions in endometrial cancer : Clinical significance and epidemiological implication. / Jeon, Yong Tark; Park, Inae; Kim, Yong Beom; Kim, Jae-Weon; Park, Nohhyun; Kang, Soon Beom; Lee, Hyo Pyo; Song, Yong-Sang.

In: Cancer Letters, Vol. 239, No. 2, 08.08.2006, p. 198-204.

Research output: Contribution to journalArticle

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T2 - Clinical significance and epidemiological implication

AU - Jeon, Yong Tark

AU - Park, Inae

AU - Kim, Yong Beom

AU - Kim, Jae-Weon

AU - Park, Nohhyun

AU - Kang, Soon Beom

AU - Lee, Hyo Pyo

AU - Song, Yong-Sang

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