Stem cells transplantation and Huntington's disease

Wooseok Im, Soon Tae Lee, Kon Chu, Manho Kim, Jae Kyu Roh

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Huntington's disease (HD) is a progressive and devastating neurodegenerative disorder that results in movement abnormalities, cognitive impairments, dementia, and affective disturbances. As no proven medical therapy for this genetic disease is currently available, symptoms mitigation is the primary treatment for HD. Stem cells can play an important role in cell therapy therapeutic strategies to replace dysfunctional or dying cells in HD. Here, we present a brief overview of the current state of stem cells therapy and of the results obtained in animal models of HD, and discuss neuroprotective approaches that utilize stem cells-derived paracrine factors.

Original languageEnglish
Pages (from-to)102-108
Number of pages7
JournalInternational Journal of Stem Cells
Volume2
Issue number2
DOIs
StatePublished - Nov 2009

Fingerprint

Huntington Disease
Stem Cell Transplantation
Stem Cells
Cell- and Tissue-Based Therapy
Inborn Genetic Diseases
Medical Genetics
Neurodegenerative Diseases
Dementia
Therapeutics
Animal Models

Keywords

  • Animal model
  • Huntington's disease
  • Stem cells

Cite this

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abstract = "Huntington's disease (HD) is a progressive and devastating neurodegenerative disorder that results in movement abnormalities, cognitive impairments, dementia, and affective disturbances. As no proven medical therapy for this genetic disease is currently available, symptoms mitigation is the primary treatment for HD. Stem cells can play an important role in cell therapy therapeutic strategies to replace dysfunctional or dying cells in HD. Here, we present a brief overview of the current state of stem cells therapy and of the results obtained in animal models of HD, and discuss neuroprotective approaches that utilize stem cells-derived paracrine factors.",
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Stem cells transplantation and Huntington's disease. / Im, Wooseok; Lee, Soon Tae; Chu, Kon; Kim, Manho; Roh, Jae Kyu.

In: International Journal of Stem Cells, Vol. 2, No. 2, 11.2009, p. 102-108.

Research output: Contribution to journalReview article

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