Smoking, longer disease duration and absence of rhinosinusitis are related to fixed airway obstruction in Koreans with severe asthma: Findings from the COREA study

Taehoon Lee, Yoon Su Lee, Yun Jeong Bae, Tae Bum Kim, Seon Ok Kim, Sang Heon Cho, Hee Bom Moon, You Sook Cho

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: The clinical manifestations of severe asthma are heterogeneous. Some individuals with severe asthma develop irreversible fixed airway obstruction, which is associated with poor outcomes. We therefore investigated the factors associated with fixed airway obstruction in Korean patients with severe asthma.Methods: Severe asthma patients from a Korean adult asthma cohort were divided into two groups according to the results of serial pulmonary function tests. One group had fixed airway obstruction (FAO) [forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) ratio < 0.7, n = 119] and the other had reversible airway obstruction (RAO) [FEV1/FVC ratio ≥ 0.7, n = 116]. Clinical and demographic parameters were compared between the two groups.Results: Multivariate analysis showed that longer duration of disease, greater amount of cigarette smoking and absence of rhinosinusitis were significantly related to the development of FAO in severe asthmatics. Other parameters, including atopic status, pattern of airway inflammatory cells in induced sputum, and frequency of asthma exacerbations did not differ between the FAO and RAO groups.Conclusion: Severe asthma patients with longer disease duration and the absence of rhinosinusitis are more likely to develop FAO. This study also demonstrates the importance of quitting smoking in order to prevent irreversible airway obstruction. Further investigation is required to determine the mechanism by which these factors can modify the disease course in Korean patients with severe asthma.

Original languageEnglish
Article number1
JournalRespiratory Research
Volume12
DOIs
StatePublished - 3 Jan 2011

Fingerprint

Airway Obstruction
Asthma
Smoking
Vital Capacity
Forced Expiratory Volume
Respiratory Function Tests
Sputum
Multivariate Analysis
Demography

Cite this

@article{358041f1d0b14d1db30fc11e79835fc7,
title = "Smoking, longer disease duration and absence of rhinosinusitis are related to fixed airway obstruction in Koreans with severe asthma: Findings from the COREA study",
abstract = "Background: The clinical manifestations of severe asthma are heterogeneous. Some individuals with severe asthma develop irreversible fixed airway obstruction, which is associated with poor outcomes. We therefore investigated the factors associated with fixed airway obstruction in Korean patients with severe asthma.Methods: Severe asthma patients from a Korean adult asthma cohort were divided into two groups according to the results of serial pulmonary function tests. One group had fixed airway obstruction (FAO) [forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) ratio < 0.7, n = 119] and the other had reversible airway obstruction (RAO) [FEV1/FVC ratio ≥ 0.7, n = 116]. Clinical and demographic parameters were compared between the two groups.Results: Multivariate analysis showed that longer duration of disease, greater amount of cigarette smoking and absence of rhinosinusitis were significantly related to the development of FAO in severe asthmatics. Other parameters, including atopic status, pattern of airway inflammatory cells in induced sputum, and frequency of asthma exacerbations did not differ between the FAO and RAO groups.Conclusion: Severe asthma patients with longer disease duration and the absence of rhinosinusitis are more likely to develop FAO. This study also demonstrates the importance of quitting smoking in order to prevent irreversible airway obstruction. Further investigation is required to determine the mechanism by which these factors can modify the disease course in Korean patients with severe asthma.",
author = "Taehoon Lee and Lee, {Yoon Su} and Bae, {Yun Jeong} and Kim, {Tae Bum} and Kim, {Seon Ok} and Cho, {Sang Heon} and Moon, {Hee Bom} and Cho, {You Sook}",
year = "2011",
month = "1",
day = "3",
doi = "10.1186/1465-9921-12-1",
language = "English",
volume = "12",
journal = "Respiratory research",
issn = "1465-9921",
publisher = "BioMed Central Ltd.",

}

Smoking, longer disease duration and absence of rhinosinusitis are related to fixed airway obstruction in Koreans with severe asthma : Findings from the COREA study. / Lee, Taehoon; Lee, Yoon Su; Bae, Yun Jeong; Kim, Tae Bum; Kim, Seon Ok; Cho, Sang Heon; Moon, Hee Bom; Cho, You Sook.

In: Respiratory Research, Vol. 12, 1, 03.01.2011.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Smoking, longer disease duration and absence of rhinosinusitis are related to fixed airway obstruction in Koreans with severe asthma

T2 - Findings from the COREA study

AU - Lee, Taehoon

AU - Lee, Yoon Su

AU - Bae, Yun Jeong

AU - Kim, Tae Bum

AU - Kim, Seon Ok

AU - Cho, Sang Heon

AU - Moon, Hee Bom

AU - Cho, You Sook

PY - 2011/1/3

Y1 - 2011/1/3

N2 - Background: The clinical manifestations of severe asthma are heterogeneous. Some individuals with severe asthma develop irreversible fixed airway obstruction, which is associated with poor outcomes. We therefore investigated the factors associated with fixed airway obstruction in Korean patients with severe asthma.Methods: Severe asthma patients from a Korean adult asthma cohort were divided into two groups according to the results of serial pulmonary function tests. One group had fixed airway obstruction (FAO) [forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) ratio < 0.7, n = 119] and the other had reversible airway obstruction (RAO) [FEV1/FVC ratio ≥ 0.7, n = 116]. Clinical and demographic parameters were compared between the two groups.Results: Multivariate analysis showed that longer duration of disease, greater amount of cigarette smoking and absence of rhinosinusitis were significantly related to the development of FAO in severe asthmatics. Other parameters, including atopic status, pattern of airway inflammatory cells in induced sputum, and frequency of asthma exacerbations did not differ between the FAO and RAO groups.Conclusion: Severe asthma patients with longer disease duration and the absence of rhinosinusitis are more likely to develop FAO. This study also demonstrates the importance of quitting smoking in order to prevent irreversible airway obstruction. Further investigation is required to determine the mechanism by which these factors can modify the disease course in Korean patients with severe asthma.

AB - Background: The clinical manifestations of severe asthma are heterogeneous. Some individuals with severe asthma develop irreversible fixed airway obstruction, which is associated with poor outcomes. We therefore investigated the factors associated with fixed airway obstruction in Korean patients with severe asthma.Methods: Severe asthma patients from a Korean adult asthma cohort were divided into two groups according to the results of serial pulmonary function tests. One group had fixed airway obstruction (FAO) [forced expiratory volume in 1 second (FEV1)/forced vital capacity (FVC) ratio < 0.7, n = 119] and the other had reversible airway obstruction (RAO) [FEV1/FVC ratio ≥ 0.7, n = 116]. Clinical and demographic parameters were compared between the two groups.Results: Multivariate analysis showed that longer duration of disease, greater amount of cigarette smoking and absence of rhinosinusitis were significantly related to the development of FAO in severe asthmatics. Other parameters, including atopic status, pattern of airway inflammatory cells in induced sputum, and frequency of asthma exacerbations did not differ between the FAO and RAO groups.Conclusion: Severe asthma patients with longer disease duration and the absence of rhinosinusitis are more likely to develop FAO. This study also demonstrates the importance of quitting smoking in order to prevent irreversible airway obstruction. Further investigation is required to determine the mechanism by which these factors can modify the disease course in Korean patients with severe asthma.

UR - http://www.scopus.com/inward/record.url?scp=78650733033&partnerID=8YFLogxK

U2 - 10.1186/1465-9921-12-1

DO - 10.1186/1465-9921-12-1

M3 - Article

C2 - 21194498

AN - SCOPUS:78650733033

VL - 12

JO - Respiratory research

JF - Respiratory research

SN - 1465-9921

M1 - 1

ER -