SK-7041, a new histone deacetylase inhibitor, induces G2-M cell cycle arrest and apoptosis in pancreatic cancer cell lines

Ji Kon Ryu, Woo Jin Lee, Kwang Hyuck Lee, Jin Hyeok Hwang, Yong Tae Kim, Yong Bum Yoon, Chung Yong Kim

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

A novel hybrid synthetic histone deacetylase inhibitor, SK-7041, was synthesized from hydroaxamic acid of trichostatin A (TSA) and pyridyl ring of MS-275. TSA and SK-7041 both induced apoptosis and G2-M cell cycle arrest in pancreatic cancer cell lines. The expressions of p21 and cyclin D2 were up-regulated and that of cyclin B1 was down-regulated by TSA or SK-7041. The expression levels of Mcl-1 and Bcl-XL but not those of Bcl-2, Bax, and Bak were suppressed by TSA or SK-7041 treatment. SK-7041 or TSA induced apoptosis and G2-M cell cycle arrest by up-regulating p21 and down-regulating cyclin B1, Mcl-1, and Bcl-XL.

Original languageEnglish
Pages (from-to)143-154
Number of pages12
JournalCancer Letters
Volume237
Issue number1
DOIs
StatePublished - 8 Jun 2006

Keywords

  • Apoptosis
  • Cell cycle
  • Histone deacetylase inhibitor
  • Pancreatic cancer
  • SK-7041

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