Single nucleotide polymorphisms in fibroblast growth factor 23 gene, FGF23, are associated with prostate cancer risk

Hae Jong Kim, Kyeoung Hwa Kim, Jaehyouk Lee, Jong Jin Oh, Hyun Sub Cheong, Ee Lin Wong, Beom Seok Yang, Seok-Soo Byun, Soon Chul Myung

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objective To determine whether sequence variants within the FGF23 gene are associated with the risk of developing prostate cancer in a Korean population. Patients and Methods Five common single nucleotide polymorphisms (SNPs) in the FGF23 gene were assessed in 272 patients with prostate cancer and 173 control subjects with benign prostatic hyperplasia. Single-locus analyses were conducted using conditional logistic regression. In addition, we performed a haplotype analysis for the five FGF23 SNPs tested. Results Three SNPs in the FGF23 gene (rs11063118, rs13312789 and rs7955866) were associated with an increased risk of prostate cancer in our study population. Odds ratios for homozygous variants vs wild-type variants ranged from 1.68 (95% confidence interval [CI]: 1.15-2.46) to 1.79 (95% CI: 1.16-2.75). Conclusion This is the first study showing that genetic variations in FGF23 increase prostate cancer susceptibility.

Original languageEnglish
Pages (from-to)303-310
Number of pages8
JournalBJU International
Volume114
Issue number2
DOIs
StatePublished - 1 Jan 2014

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Single Nucleotide Polymorphism
Prostatic Neoplasms
Genes
Confidence Intervals
Prostatic Hyperplasia
Haplotypes
Population
Logistic Models
Odds Ratio
fibroblast growth factor 23

Keywords

  • FGF23
  • polymorphism
  • prostate cancer

Cite this

Kim, Hae Jong ; Kim, Kyeoung Hwa ; Lee, Jaehyouk ; Oh, Jong Jin ; Cheong, Hyun Sub ; Wong, Ee Lin ; Yang, Beom Seok ; Byun, Seok-Soo ; Myung, Soon Chul. / Single nucleotide polymorphisms in fibroblast growth factor 23 gene, FGF23, are associated with prostate cancer risk. In: BJU International. 2014 ; Vol. 114, No. 2. pp. 303-310.
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abstract = "Objective To determine whether sequence variants within the FGF23 gene are associated with the risk of developing prostate cancer in a Korean population. Patients and Methods Five common single nucleotide polymorphisms (SNPs) in the FGF23 gene were assessed in 272 patients with prostate cancer and 173 control subjects with benign prostatic hyperplasia. Single-locus analyses were conducted using conditional logistic regression. In addition, we performed a haplotype analysis for the five FGF23 SNPs tested. Results Three SNPs in the FGF23 gene (rs11063118, rs13312789 and rs7955866) were associated with an increased risk of prostate cancer in our study population. Odds ratios for homozygous variants vs wild-type variants ranged from 1.68 (95{\%} confidence interval [CI]: 1.15-2.46) to 1.79 (95{\%} CI: 1.16-2.75). Conclusion This is the first study showing that genetic variations in FGF23 increase prostate cancer susceptibility.",
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Single nucleotide polymorphisms in fibroblast growth factor 23 gene, FGF23, are associated with prostate cancer risk. / Kim, Hae Jong; Kim, Kyeoung Hwa; Lee, Jaehyouk; Oh, Jong Jin; Cheong, Hyun Sub; Wong, Ee Lin; Yang, Beom Seok; Byun, Seok-Soo; Myung, Soon Chul.

In: BJU International, Vol. 114, No. 2, 01.01.2014, p. 303-310.

Research output: Contribution to journalArticle

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T1 - Single nucleotide polymorphisms in fibroblast growth factor 23 gene, FGF23, are associated with prostate cancer risk

AU - Kim, Hae Jong

AU - Kim, Kyeoung Hwa

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AU - Cheong, Hyun Sub

AU - Wong, Ee Lin

AU - Yang, Beom Seok

AU - Byun, Seok-Soo

AU - Myung, Soon Chul

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N2 - Objective To determine whether sequence variants within the FGF23 gene are associated with the risk of developing prostate cancer in a Korean population. Patients and Methods Five common single nucleotide polymorphisms (SNPs) in the FGF23 gene were assessed in 272 patients with prostate cancer and 173 control subjects with benign prostatic hyperplasia. Single-locus analyses were conducted using conditional logistic regression. In addition, we performed a haplotype analysis for the five FGF23 SNPs tested. Results Three SNPs in the FGF23 gene (rs11063118, rs13312789 and rs7955866) were associated with an increased risk of prostate cancer in our study population. Odds ratios for homozygous variants vs wild-type variants ranged from 1.68 (95% confidence interval [CI]: 1.15-2.46) to 1.79 (95% CI: 1.16-2.75). Conclusion This is the first study showing that genetic variations in FGF23 increase prostate cancer susceptibility.

AB - Objective To determine whether sequence variants within the FGF23 gene are associated with the risk of developing prostate cancer in a Korean population. Patients and Methods Five common single nucleotide polymorphisms (SNPs) in the FGF23 gene were assessed in 272 patients with prostate cancer and 173 control subjects with benign prostatic hyperplasia. Single-locus analyses were conducted using conditional logistic regression. In addition, we performed a haplotype analysis for the five FGF23 SNPs tested. Results Three SNPs in the FGF23 gene (rs11063118, rs13312789 and rs7955866) were associated with an increased risk of prostate cancer in our study population. Odds ratios for homozygous variants vs wild-type variants ranged from 1.68 (95% confidence interval [CI]: 1.15-2.46) to 1.79 (95% CI: 1.16-2.75). Conclusion This is the first study showing that genetic variations in FGF23 increase prostate cancer susceptibility.

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