Simple and generalized synthesis of oxide-metal heterostructured nanoparticles and their applications in multimodal biomedical probes

Sang Hyun Choi, Bin Na Hyon, Il Park Yong, Kwangjin An, Gu Kwon Soon, Youngjin Jang, Mi Hyun Park, Jaewon Moon, Sung Son Jae, Chan Song In, Kyung Moon Woo, Taeghwan Hyeon

Research output: Contribution to journalArticle

142 Citations (Scopus)

Abstract

Heterostructured nanoparticles composed of metals and Fe3O 4 or MnO were synthesized by thermal decomposition of mixtures of metal-oleate complexes (for the oxide component) and metal-oleylamine complexes (for the metal component). The products included flowerlike-shaped nanoparticles of Pt-Fe3O4 and Ni-Fe3O4 and snowmanlike-shaped nanoparticles of Ag-MnO and Au-MnO. Powder X-ray diffraction patterns showed that these nanoparticles were composed of face-centered cubic (fcc)-structured Fe3O4 or MnO and fcc-structured metals. The relaxivity values of the Au-MnO and Au-Fe3O4 nanoparticles were similar to those of the MnO and Fe3O4 nanoparticles, respectively. Au-Fe3O4 heterostructured nanoparticles conjugated with two kinds of 12-base oligonucleotide sequences were able to sense a complementary 24-mer sequence, causing nanoparticle aggregation. This hybridization-mediated aggregation was detected by the overall size increase indicated by dynamic light scattering data, the red shift of the surface plasmon band of the Au component, and the enhancement of the signal intensity of the Fe3O4 component in T2-weighted magnetic resonance imaging.

Original languageEnglish
Pages (from-to)15573-15580
Number of pages8
JournalJournal of the American Chemical Society
Volume130
Issue number46
DOIs
StatePublished - 19 Nov 2008

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Metal Nanoparticles
Metal nanoparticles
Nanoparticles
Oxides
Coordination Complexes
Metal complexes
Metals
Agglomeration
Oleic Acid
Oligonucleotides
X-Ray Diffraction
Powders
Dynamic light scattering
Magnetic resonance
Diffraction patterns
Hot Temperature
Magnetic Resonance Imaging
Pyrolysis
Imaging techniques
X rays

Cite this

Choi, Sang Hyun ; Hyon, Bin Na ; Yong, Il Park ; An, Kwangjin ; Soon, Gu Kwon ; Jang, Youngjin ; Park, Mi Hyun ; Moon, Jaewon ; Jae, Sung Son ; In, Chan Song ; Woo, Kyung Moon ; Hyeon, Taeghwan. / Simple and generalized synthesis of oxide-metal heterostructured nanoparticles and their applications in multimodal biomedical probes. In: Journal of the American Chemical Society. 2008 ; Vol. 130, No. 46. pp. 15573-15580.
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abstract = "Heterostructured nanoparticles composed of metals and Fe3O 4 or MnO were synthesized by thermal decomposition of mixtures of metal-oleate complexes (for the oxide component) and metal-oleylamine complexes (for the metal component). The products included flowerlike-shaped nanoparticles of Pt-Fe3O4 and Ni-Fe3O4 and snowmanlike-shaped nanoparticles of Ag-MnO and Au-MnO. Powder X-ray diffraction patterns showed that these nanoparticles were composed of face-centered cubic (fcc)-structured Fe3O4 or MnO and fcc-structured metals. The relaxivity values of the Au-MnO and Au-Fe3O4 nanoparticles were similar to those of the MnO and Fe3O4 nanoparticles, respectively. Au-Fe3O4 heterostructured nanoparticles conjugated with two kinds of 12-base oligonucleotide sequences were able to sense a complementary 24-mer sequence, causing nanoparticle aggregation. This hybridization-mediated aggregation was detected by the overall size increase indicated by dynamic light scattering data, the red shift of the surface plasmon band of the Au component, and the enhancement of the signal intensity of the Fe3O4 component in T2-weighted magnetic resonance imaging.",
author = "Choi, {Sang Hyun} and Hyon, {Bin Na} and Yong, {Il Park} and Kwangjin An and Soon, {Gu Kwon} and Youngjin Jang and Park, {Mi Hyun} and Jaewon Moon and Jae, {Sung Son} and In, {Chan Song} and Woo, {Kyung Moon} and Taeghwan Hyeon",
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Choi, SH, Hyon, BN, Yong, IP, An, K, Soon, GK, Jang, Y, Park, MH, Moon, J, Jae, SS, In, CS, Woo, KM & Hyeon, T 2008, 'Simple and generalized synthesis of oxide-metal heterostructured nanoparticles and their applications in multimodal biomedical probes', Journal of the American Chemical Society, vol. 130, no. 46, pp. 15573-15580. https://doi.org/10.1021/ja805311x

Simple and generalized synthesis of oxide-metal heterostructured nanoparticles and their applications in multimodal biomedical probes. / Choi, Sang Hyun; Hyon, Bin Na; Yong, Il Park; An, Kwangjin; Soon, Gu Kwon; Jang, Youngjin; Park, Mi Hyun; Moon, Jaewon; Jae, Sung Son; In, Chan Song; Woo, Kyung Moon; Hyeon, Taeghwan.

In: Journal of the American Chemical Society, Vol. 130, No. 46, 19.11.2008, p. 15573-15580.

Research output: Contribution to journalArticle

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AU - Choi, Sang Hyun

AU - Hyon, Bin Na

AU - Yong, Il Park

AU - An, Kwangjin

AU - Soon, Gu Kwon

AU - Jang, Youngjin

AU - Park, Mi Hyun

AU - Moon, Jaewon

AU - Jae, Sung Son

AU - In, Chan Song

AU - Woo, Kyung Moon

AU - Hyeon, Taeghwan

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Y1 - 2008/11/19

N2 - Heterostructured nanoparticles composed of metals and Fe3O 4 or MnO were synthesized by thermal decomposition of mixtures of metal-oleate complexes (for the oxide component) and metal-oleylamine complexes (for the metal component). The products included flowerlike-shaped nanoparticles of Pt-Fe3O4 and Ni-Fe3O4 and snowmanlike-shaped nanoparticles of Ag-MnO and Au-MnO. Powder X-ray diffraction patterns showed that these nanoparticles were composed of face-centered cubic (fcc)-structured Fe3O4 or MnO and fcc-structured metals. The relaxivity values of the Au-MnO and Au-Fe3O4 nanoparticles were similar to those of the MnO and Fe3O4 nanoparticles, respectively. Au-Fe3O4 heterostructured nanoparticles conjugated with two kinds of 12-base oligonucleotide sequences were able to sense a complementary 24-mer sequence, causing nanoparticle aggregation. This hybridization-mediated aggregation was detected by the overall size increase indicated by dynamic light scattering data, the red shift of the surface plasmon band of the Au component, and the enhancement of the signal intensity of the Fe3O4 component in T2-weighted magnetic resonance imaging.

AB - Heterostructured nanoparticles composed of metals and Fe3O 4 or MnO were synthesized by thermal decomposition of mixtures of metal-oleate complexes (for the oxide component) and metal-oleylamine complexes (for the metal component). The products included flowerlike-shaped nanoparticles of Pt-Fe3O4 and Ni-Fe3O4 and snowmanlike-shaped nanoparticles of Ag-MnO and Au-MnO. Powder X-ray diffraction patterns showed that these nanoparticles were composed of face-centered cubic (fcc)-structured Fe3O4 or MnO and fcc-structured metals. The relaxivity values of the Au-MnO and Au-Fe3O4 nanoparticles were similar to those of the MnO and Fe3O4 nanoparticles, respectively. Au-Fe3O4 heterostructured nanoparticles conjugated with two kinds of 12-base oligonucleotide sequences were able to sense a complementary 24-mer sequence, causing nanoparticle aggregation. This hybridization-mediated aggregation was detected by the overall size increase indicated by dynamic light scattering data, the red shift of the surface plasmon band of the Au component, and the enhancement of the signal intensity of the Fe3O4 component in T2-weighted magnetic resonance imaging.

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