Silicone implant coated with tranilast-loaded polymer in a pattern for fibrosis suppression

Byung Hwi Kim, Beom Kang Huh, Won Suk Lee, Cho Rim Kim, Kyu Sang Lee, Sun Young Nam, Miji Lee, Chan Yeong Heo, Young Bin Choy

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Pathologic fibrosis around silicone implants is problematic, and thus, these implants have been coated with a mixture of a biocompatible polymer and antifibrotic drug for sustained drug release to prevent fibrosis. However, a coating applied over an entire surface would be subject to mechanical instability as the implant would be severely crumpled for implant insertion. Therefore, in this work, we proposed localized, patterned coating dots, each composed of poly(lactic-co-glycolic acid) (PLGA) and tranilast, to be applied on the surface of silicone implants. The drug loaded in the pattern-coated implant herein was well retained after a cyclic tensile test. Due to the presence of PLGA in each coating dot, the tranilast could be released in a sustained manner for more than 14 days. When implanted in a subcutaneous pocket in living rats for 12 weeks, compared with the intact implant, the pattern-coated implant showed a decreased capsule thickness and collagen density, as well as less transforming growth factor-β (TGF-β) expression and fewer fibroblasts; importantly, these changes were similar between the surfaces with and without the coating dots. Therefore, we conclude that the pattern-coating strategy proposed in this study can still effectively prevent fibrosis by maintaining the physical stability of the coatings.

Original languageEnglish
Article number223
JournalPolymers
Volume11
Issue number2
DOIs
StatePublished - 30 Jan 2019

Fingerprint

Silicones
Polymers
Coatings
Pharmaceutical Preparations
Acids
Transforming Growth Factors
Fibroblasts
Collagen
Capsules
tranilast
Rats

Keywords

  • Drug delivery
  • Fibrosis
  • Pattern coatings
  • Silicone implant
  • Tranilast

Cite this

Kim, Byung Hwi ; Huh, Beom Kang ; Lee, Won Suk ; Kim, Cho Rim ; Lee, Kyu Sang ; Nam, Sun Young ; Lee, Miji ; Heo, Chan Yeong ; Choy, Young Bin. / Silicone implant coated with tranilast-loaded polymer in a pattern for fibrosis suppression. In: Polymers. 2019 ; Vol. 11, No. 2.
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abstract = "Pathologic fibrosis around silicone implants is problematic, and thus, these implants have been coated with a mixture of a biocompatible polymer and antifibrotic drug for sustained drug release to prevent fibrosis. However, a coating applied over an entire surface would be subject to mechanical instability as the implant would be severely crumpled for implant insertion. Therefore, in this work, we proposed localized, patterned coating dots, each composed of poly(lactic-co-glycolic acid) (PLGA) and tranilast, to be applied on the surface of silicone implants. The drug loaded in the pattern-coated implant herein was well retained after a cyclic tensile test. Due to the presence of PLGA in each coating dot, the tranilast could be released in a sustained manner for more than 14 days. When implanted in a subcutaneous pocket in living rats for 12 weeks, compared with the intact implant, the pattern-coated implant showed a decreased capsule thickness and collagen density, as well as less transforming growth factor-β (TGF-β) expression and fewer fibroblasts; importantly, these changes were similar between the surfaces with and without the coating dots. Therefore, we conclude that the pattern-coating strategy proposed in this study can still effectively prevent fibrosis by maintaining the physical stability of the coatings.",
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Silicone implant coated with tranilast-loaded polymer in a pattern for fibrosis suppression. / Kim, Byung Hwi; Huh, Beom Kang; Lee, Won Suk; Kim, Cho Rim; Lee, Kyu Sang; Nam, Sun Young; Lee, Miji; Heo, Chan Yeong; Choy, Young Bin.

In: Polymers, Vol. 11, No. 2, 223, 30.01.2019.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Silicone implant coated with tranilast-loaded polymer in a pattern for fibrosis suppression

AU - Kim, Byung Hwi

AU - Huh, Beom Kang

AU - Lee, Won Suk

AU - Kim, Cho Rim

AU - Lee, Kyu Sang

AU - Nam, Sun Young

AU - Lee, Miji

AU - Heo, Chan Yeong

AU - Choy, Young Bin

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N2 - Pathologic fibrosis around silicone implants is problematic, and thus, these implants have been coated with a mixture of a biocompatible polymer and antifibrotic drug for sustained drug release to prevent fibrosis. However, a coating applied over an entire surface would be subject to mechanical instability as the implant would be severely crumpled for implant insertion. Therefore, in this work, we proposed localized, patterned coating dots, each composed of poly(lactic-co-glycolic acid) (PLGA) and tranilast, to be applied on the surface of silicone implants. The drug loaded in the pattern-coated implant herein was well retained after a cyclic tensile test. Due to the presence of PLGA in each coating dot, the tranilast could be released in a sustained manner for more than 14 days. When implanted in a subcutaneous pocket in living rats for 12 weeks, compared with the intact implant, the pattern-coated implant showed a decreased capsule thickness and collagen density, as well as less transforming growth factor-β (TGF-β) expression and fewer fibroblasts; importantly, these changes were similar between the surfaces with and without the coating dots. Therefore, we conclude that the pattern-coating strategy proposed in this study can still effectively prevent fibrosis by maintaining the physical stability of the coatings.

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