Short- And long-term outcomes of preterm spontaneous twin anemia-polycythemia sequence

Soo Jin Han, Seung Mi Lee, Sohee Oh, Subeen Hong, Jeong Won Oh, Seung Han Shin, Chan Wook Park, Joong Shin Park, Jong Kwan Jun

Research output: Contribution to journalArticle


In monochorionic twin pregnancy, placental anastomosis and inter-twin blood transfusion can result in specific complications, such as twin-twin transfusion syndrome (TTTS) and twin anemia-polycythemia sequence (TAPS). It is well established that adverse outcomes are increased in TTTS, but reports on the neonatal and long-term outcomes of TAPS are lacking. The objective of this study was to evaluate the neonatal and neurodevelopmental outcomes in spontaneous TAPS. The study population consisted of monochorionic twin pregnancies with preterm birth (24-37 weeks of gestation) between November 2003 and December 2016 and in which cord blood was taken at the time of delivery. According to the result of hemoglobin in cord blood, the study population was divided into two groups: a spontaneous TAPS group and a control group. Neonatal and neurodevelopmental outcomes were compared between the two groups. During the study period, 11 cases were diagnosed as spontaneous TAPS (6.4%). The TAPS group had lower gestational age at delivery and had a higher risk for cesarean delivery. However, neonates with TAPS were not at an increased risk for neonatal mortality and significant neonatal morbidity. In addition, the frequency of severe cerebral lesion during the neonatal period and the risk of cerebral palsy at 2 years of age were not different between the two groups. The spontaneous TAPS diagnosed by postnatal diagnostic criteria was not associated with the increased risk of adverse neonatal and neurodevelopmental outcomes. Further studies are needed to evaluate the morbidity of antenatally diagnosed TAPS.

Original languageEnglish
Pages (from-to)329-334
Number of pages6
JournalJournal of Perinatal Medicine
Issue number4
StatePublished - 2020


  • monochorionic twin pregnancy
  • neonatal morbidity
  • neurodevelopmental impairment
  • twin anemia-polycythemia sequence

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