Short- And long-term outcomes of pancreaticoduodenectomy in elderly patients with periampullary cancer

Jae Seung Kang, Hongbeom Kim, Jae Ri Kim, Youngmin Han, Eunjung Kim, Yoonhyeong Byun, Yoo Jin Choi, Wooil Kwon, Jin Young Jang, Sun Whe Kim

Research output: Contribution to journalArticle

Abstract

Purpose: Pancreaticoduodenectomy (PD) is recently performed in older cancer patients. The complication rate of PD is high. The present study was to compare the postoperative short- and long-term outcomes of PD in between older patients and younger patients. Methods: Between 2000 and 2014, patients who underwent PD due to periampullary cancers were enrolled. Patients aged 75 years or over were included in the older group. Results: Total 1,249 patients were enrolled in this study and 168 patients (13.5%) were included in the older group. Postoperative complication rates, duration of postoperative hospital stay, and 30-day mortality were comparable between the 2 groups, although the admission rate of intensive care unit postoperatively was higher in the older adult group (20.8% vs. 10.5%, P < 0.001). In terms of long-term outcomes, 5-year overall survival rate was lower in the older group (23.4% vs. 41.8%, P < 0.001), and 5-year cumulative recurrence rate was higher in the older group without statistical significance (63.9% vs. 57.9%, P = 0.095). However, there were no statistical differences of cumulative recurrence in pancreatic cancer patients (81.5% vs. 82.5%, P = 0.805). Conclusion: PD for periampullary cancer is a safe and feasible treatment in the older patients. The treatment modality for obtaining better survival outcomes will be investigated.

Original languageEnglish
Pages (from-to)7-14
Number of pages8
JournalAnnals of Surgical Treatment and Research
Volume98
Issue number1
DOIs
StatePublished - 1 Jan 2020

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Keywords

  • Geriatric assessment
  • Outcome assessment
  • Pancreaticoduodenectomy
  • Recurrence
  • Survival

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